Sex Differences in Parkinson’s Disease: From Bench to Bedside
Background: Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease and gender differences have been described on several aspects of PD. In the present commentary, we aimed to collect and discuss the currently available evidence on gender differences i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/7/917 |
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| author | Maria Claudia Russillo Valentina Andreozzi Roberto Erro Marina Picillo Marianna Amboni Sofia Cuoco Paolo Barone Maria Teresa Pellecchia |
| author_facet | Maria Claudia Russillo Valentina Andreozzi Roberto Erro Marina Picillo Marianna Amboni Sofia Cuoco Paolo Barone Maria Teresa Pellecchia |
| author_sort | Maria Claudia Russillo |
| collection | DOAJ |
| description | Background: Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease and gender differences have been described on several aspects of PD. In the present commentary, we aimed to collect and discuss the currently available evidence on gender differences in PD regarding biomarkers, genetic factors, motor and non-motor symptoms, therapeutic management (including pharmacological and surgical treatment) as well as preclinical studies. Methods: A systematic literature review was performed by searching the Pubmed and Scopus databases with the search strings “biomarkers”, “deep brain stimulation”, “female”, “gender”, “genetic”, “levodopa”, “men”, “male”, “motor symptoms”, “non-motor symptoms”, “Parkinson disease”, “sex”, “surgery”, and “women”. Results: The present review confirms the existence of differences between men and women in Parkinson Disease, pointing out new information regarding evidence from animal models, genetic factors, biomarkers, clinical features and pharmacological and surgical treatment. Conclusions: The overall goal is to acquire new informations about sex and gender differences in Parkinson Disease, in order to develop tailored intervetions. |
| first_indexed | 2024-03-09T10:21:08Z |
| format | Article |
| id | doaj.art-4b0155befde94ba287cdb7bebf7b5689 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T10:21:08Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-4b0155befde94ba287cdb7bebf7b56892023-12-01T21:57:45ZengMDPI AGBrain Sciences2076-34252022-07-0112791710.3390/brainsci12070917Sex Differences in Parkinson’s Disease: From Bench to BedsideMaria Claudia Russillo0Valentina Andreozzi1Roberto Erro2Marina Picillo3Marianna Amboni4Sofia Cuoco5Paolo Barone6Maria Teresa Pellecchia7Center for Neurodegenerative Diseases (CEMAND), Department of Medicine, Surgery and Odontology “Scuola Medica Salernitana”, University of Salerno, 84084 Fisciano, ItalyCenter for Neurodegenerative Diseases (CEMAND), Department of Medicine, Surgery and Odontology “Scuola Medica Salernitana”, University of Salerno, 84084 Fisciano, ItalyCenter for Neurodegenerative Diseases (CEMAND), Department of Medicine, Surgery and Odontology “Scuola Medica Salernitana”, University of Salerno, 84084 Fisciano, ItalyCenter for Neurodegenerative Diseases (CEMAND), Department of Medicine, Surgery and Odontology “Scuola Medica Salernitana”, University of Salerno, 84084 Fisciano, ItalyCenter for Neurodegenerative Diseases (CEMAND), Department of Medicine, Surgery and Odontology “Scuola Medica Salernitana”, University of Salerno, 84084 Fisciano, ItalyCenter for Neurodegenerative Diseases (CEMAND), Department of Medicine, Surgery and Odontology “Scuola Medica Salernitana”, University of Salerno, 84084 Fisciano, ItalyCenter for Neurodegenerative Diseases (CEMAND), Department of Medicine, Surgery and Odontology “Scuola Medica Salernitana”, University of Salerno, 84084 Fisciano, ItalyCenter for Neurodegenerative Diseases (CEMAND), Department of Medicine, Surgery and Odontology “Scuola Medica Salernitana”, University of Salerno, 84084 Fisciano, ItalyBackground: Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease and gender differences have been described on several aspects of PD. In the present commentary, we aimed to collect and discuss the currently available evidence on gender differences in PD regarding biomarkers, genetic factors, motor and non-motor symptoms, therapeutic management (including pharmacological and surgical treatment) as well as preclinical studies. Methods: A systematic literature review was performed by searching the Pubmed and Scopus databases with the search strings “biomarkers”, “deep brain stimulation”, “female”, “gender”, “genetic”, “levodopa”, “men”, “male”, “motor symptoms”, “non-motor symptoms”, “Parkinson disease”, “sex”, “surgery”, and “women”. Results: The present review confirms the existence of differences between men and women in Parkinson Disease, pointing out new information regarding evidence from animal models, genetic factors, biomarkers, clinical features and pharmacological and surgical treatment. Conclusions: The overall goal is to acquire new informations about sex and gender differences in Parkinson Disease, in order to develop tailored intervetions.https://www.mdpi.com/2076-3425/12/7/917Parkinson’s diseasegendersex |
| spellingShingle | Maria Claudia Russillo Valentina Andreozzi Roberto Erro Marina Picillo Marianna Amboni Sofia Cuoco Paolo Barone Maria Teresa Pellecchia Sex Differences in Parkinson’s Disease: From Bench to Bedside Brain Sciences Parkinson’s disease gender sex |
| title | Sex Differences in Parkinson’s Disease: From Bench to Bedside |
| title_full | Sex Differences in Parkinson’s Disease: From Bench to Bedside |
| title_fullStr | Sex Differences in Parkinson’s Disease: From Bench to Bedside |
| title_full_unstemmed | Sex Differences in Parkinson’s Disease: From Bench to Bedside |
| title_short | Sex Differences in Parkinson’s Disease: From Bench to Bedside |
| title_sort | sex differences in parkinson s disease from bench to bedside |
| topic | Parkinson’s disease gender sex |
| url | https://www.mdpi.com/2076-3425/12/7/917 |
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