Protective effects of Lactobacillus plantarum C88 on chronic ethanol-induced liver injury in mice
The protective effects of L. plantarum C88 against chronic alcohol-induced liver injury in mice were investigated. The pretreatment with L. plantarum C88 significantly decreased the levels of alanine transaminase and aspartate aminotransferase in chronic alcohol-challenged mice. L. plantarum C88 was...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617302700 |
| _version_ | 1818938218456809472 |
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| author | Lei Zhao Yu Jiang Yuxin Ni Tianzhu Zhang Cuicui Duan Cheng Huang Yujuan Zhao Lei Gao Shengyu Li |
| author_facet | Lei Zhao Yu Jiang Yuxin Ni Tianzhu Zhang Cuicui Duan Cheng Huang Yujuan Zhao Lei Gao Shengyu Li |
| author_sort | Lei Zhao |
| collection | DOAJ |
| description | The protective effects of L. plantarum C88 against chronic alcohol-induced liver injury in mice were investigated. The pretreatment with L. plantarum C88 significantly decreased the levels of alanine transaminase and aspartate aminotransferase in chronic alcohol-challenged mice. L. plantarum C88 was also found to suppress the content of malondialdehyde (MDA) and enhance the activity of superoxide dismutase (SOD) in the liver, which are well-correlated with the downregulation of hepatic cytochrome P450 2E1 and upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2). Moreover, L. plantarum C88 significantly abrogated the increased serum levels of TNF-α, IL-6, and IFN-γ induced by ethanol. L. plantarum C88 ameliorated gut leakiness by upregulating the expressions of tight junction proteins and suppressed the endotoxin-mediated inflammation by decreasing P38 phosphorylation and down-regulating NF-κB. These results demonstrate that L. plantarum C88 efficiently protects against alcoholic chronic liver injury. |
| first_indexed | 2024-12-20T06:04:22Z |
| format | Article |
| id | doaj.art-4b02c442484047e29a09365b83791622 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T06:04:22Z |
| publishDate | 2017-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-4b02c442484047e29a09365b837916222022-12-21T19:50:51ZengElsevierJournal of Functional Foods1756-46462017-08-013597104Protective effects of Lactobacillus plantarum C88 on chronic ethanol-induced liver injury in miceLei Zhao0Yu Jiang1Yuxin Ni2Tianzhu Zhang3Cuicui Duan4Cheng Huang5Yujuan Zhao6Lei Gao7Shengyu Li8School of Basic Medical Sciences, Changchun University of Chinese Medicine, Changchun 130117, PR ChinaHigh School Attached to Northeast Normal University, Changchun 130117, PR ChinaDepartment of Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, PR ChinaSchool of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun 130117, PR ChinaInstitute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR ChinaInstitute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR ChinaInstitute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR ChinaInstitute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR ChinaInstitute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130033, PR China; Corresponding author at: Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, No. 1363 Sheng-Tai Street, Changchun, Jilin Province 130033, PR China.The protective effects of L. plantarum C88 against chronic alcohol-induced liver injury in mice were investigated. The pretreatment with L. plantarum C88 significantly decreased the levels of alanine transaminase and aspartate aminotransferase in chronic alcohol-challenged mice. L. plantarum C88 was also found to suppress the content of malondialdehyde (MDA) and enhance the activity of superoxide dismutase (SOD) in the liver, which are well-correlated with the downregulation of hepatic cytochrome P450 2E1 and upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2). Moreover, L. plantarum C88 significantly abrogated the increased serum levels of TNF-α, IL-6, and IFN-γ induced by ethanol. L. plantarum C88 ameliorated gut leakiness by upregulating the expressions of tight junction proteins and suppressed the endotoxin-mediated inflammation by decreasing P38 phosphorylation and down-regulating NF-κB. These results demonstrate that L. plantarum C88 efficiently protects against alcoholic chronic liver injury.http://www.sciencedirect.com/science/article/pii/S1756464617302700Lactobacillus plantarumHepatoprotectiveAnti-oxidationAnti-inflammationIntestinal barrier |
| spellingShingle | Lei Zhao Yu Jiang Yuxin Ni Tianzhu Zhang Cuicui Duan Cheng Huang Yujuan Zhao Lei Gao Shengyu Li Protective effects of Lactobacillus plantarum C88 on chronic ethanol-induced liver injury in mice Journal of Functional Foods Lactobacillus plantarum Hepatoprotective Anti-oxidation Anti-inflammation Intestinal barrier |
| title | Protective effects of Lactobacillus plantarum C88 on chronic ethanol-induced liver injury in mice |
| title_full | Protective effects of Lactobacillus plantarum C88 on chronic ethanol-induced liver injury in mice |
| title_fullStr | Protective effects of Lactobacillus plantarum C88 on chronic ethanol-induced liver injury in mice |
| title_full_unstemmed | Protective effects of Lactobacillus plantarum C88 on chronic ethanol-induced liver injury in mice |
| title_short | Protective effects of Lactobacillus plantarum C88 on chronic ethanol-induced liver injury in mice |
| title_sort | protective effects of lactobacillus plantarum c88 on chronic ethanol induced liver injury in mice |
| topic | Lactobacillus plantarum Hepatoprotective Anti-oxidation Anti-inflammation Intestinal barrier |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617302700 |
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