Emerging Neurological and Psychobiological Aspects of COVID-19 Infection
The SARS-CoV-2 virus, first reported in December 2019 in China, is the causative agent of the current COVID-19 pandemic that, at the time of writing (1 November 2020) has infected almost 43 million people and caused the death of more than 1 million people. The spectrum of clinical manifestations obs...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/11/852 |
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| author | Lyubka Tancheva Maria Cristina Petralia Simona Miteva Stela Dragomanova Ayten Solak Reni Kalfin Maria Lazarova Dobri Yarkov Rosella Ciurleo Eugenio Cavalli Alessia Bramanti Ferdinando Nicoletti |
| author_facet | Lyubka Tancheva Maria Cristina Petralia Simona Miteva Stela Dragomanova Ayten Solak Reni Kalfin Maria Lazarova Dobri Yarkov Rosella Ciurleo Eugenio Cavalli Alessia Bramanti Ferdinando Nicoletti |
| author_sort | Lyubka Tancheva |
| collection | DOAJ |
| description | The SARS-CoV-2 virus, first reported in December 2019 in China, is the causative agent of the current COVID-19 pandemic that, at the time of writing (1 November 2020) has infected almost 43 million people and caused the death of more than 1 million people. The spectrum of clinical manifestations observed during COVID-19 infection varies from asymptomatic to critical life-threatening clinical conditions. Emerging evidence shows that COVID-19 affects far more organs than just the respiratory system, including the heart, kidneys, blood vessels, liver, as well as the central nervous system (CNS) and the peripheral nervous system (PNS). It is also becoming clear that the neurological and psychological disturbances that occur during the acute phase of the infection may persist well beyond the recovery. The aim of this review is to propel further this emerging and relevant field of research related to the pathophysiology of neurological manifestation of COVID-19 infection (Neuro-COVID). We will summarize the PNS and CNS symptoms experienced by people with COVID-19 both during infection and in the recovery phase. Diagnostic and pharmacological findings in this field of study are strongly warranted to address the neurological and psychological symptoms of COVID-19. |
| first_indexed | 2024-03-10T14:53:47Z |
| format | Article |
| id | doaj.art-4b02dad2f5354482bc2808707b5ce389 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T14:53:47Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-4b02dad2f5354482bc2808707b5ce3892023-11-20T20:46:53ZengMDPI AGBrain Sciences2076-34252020-11-01101185210.3390/brainsci10110852Emerging Neurological and Psychobiological Aspects of COVID-19 InfectionLyubka Tancheva0Maria Cristina Petralia1Simona Miteva2Stela Dragomanova3Ayten Solak4Reni Kalfin5Maria Lazarova6Dobri Yarkov7Rosella Ciurleo8Eugenio Cavalli9Alessia Bramanti10Ferdinando Nicoletti11Department of Behavior Neurobiology, Institute of Neurobiology, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaIRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, ItalyDepartment of Behavior Neurobiology, Institute of Neurobiology, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaDepartment of Behavior Neurobiology, Institute of Neurobiology, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaInstitute of Cryobiology and food technologies, Agricultural Academy, 1407 Sofia, BulgariaDepartment of Behavior Neurobiology, Institute of Neurobiology, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaDepartment of Behavior Neurobiology, Institute of Neurobiology, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaFaculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, BulgariaIRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia 89, 95123 Catania, ItalyIRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia 89, 95123 Catania, ItalyThe SARS-CoV-2 virus, first reported in December 2019 in China, is the causative agent of the current COVID-19 pandemic that, at the time of writing (1 November 2020) has infected almost 43 million people and caused the death of more than 1 million people. The spectrum of clinical manifestations observed during COVID-19 infection varies from asymptomatic to critical life-threatening clinical conditions. Emerging evidence shows that COVID-19 affects far more organs than just the respiratory system, including the heart, kidneys, blood vessels, liver, as well as the central nervous system (CNS) and the peripheral nervous system (PNS). It is also becoming clear that the neurological and psychological disturbances that occur during the acute phase of the infection may persist well beyond the recovery. The aim of this review is to propel further this emerging and relevant field of research related to the pathophysiology of neurological manifestation of COVID-19 infection (Neuro-COVID). We will summarize the PNS and CNS symptoms experienced by people with COVID-19 both during infection and in the recovery phase. Diagnostic and pharmacological findings in this field of study are strongly warranted to address the neurological and psychological symptoms of COVID-19.https://www.mdpi.com/2076-3425/10/11/852COVID-19cytokinescentral nervous systemNeuro-COVIDParkinson’s diseaseperipheral nervous system |
| spellingShingle | Lyubka Tancheva Maria Cristina Petralia Simona Miteva Stela Dragomanova Ayten Solak Reni Kalfin Maria Lazarova Dobri Yarkov Rosella Ciurleo Eugenio Cavalli Alessia Bramanti Ferdinando Nicoletti Emerging Neurological and Psychobiological Aspects of COVID-19 Infection Brain Sciences COVID-19 cytokines central nervous system Neuro-COVID Parkinson’s disease peripheral nervous system |
| title | Emerging Neurological and Psychobiological Aspects of COVID-19 Infection |
| title_full | Emerging Neurological and Psychobiological Aspects of COVID-19 Infection |
| title_fullStr | Emerging Neurological and Psychobiological Aspects of COVID-19 Infection |
| title_full_unstemmed | Emerging Neurological and Psychobiological Aspects of COVID-19 Infection |
| title_short | Emerging Neurological and Psychobiological Aspects of COVID-19 Infection |
| title_sort | emerging neurological and psychobiological aspects of covid 19 infection |
| topic | COVID-19 cytokines central nervous system Neuro-COVID Parkinson’s disease peripheral nervous system |
| url | https://www.mdpi.com/2076-3425/10/11/852 |
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