Utility of the Modified and High-Sensitivity Modified Glasgow Prognostic Scores for Hypopharyngeal Squamous Cell Carcinoma
Objective To determine whether the modified Glasgow prognostic score (mGPS) and high-sensitivity mGPS (HS-mGPS) could predict outcomes among patients with hypopharyngeal squamous cell carcinoma (HSCC). Study Design Retrospective cohort study. Setting Affiliated university hospital. Methods We review...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-12-01
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| Series: | OTO Open |
| Online Access: | https://doi.org/10.1177/2473974X211067423 |
| _version_ | 1827776358692945920 |
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| author | Hiroyuki Iuchi MD, PhD Junichiro Ohori MD, PhD Hisahiro Matsuzaki MD Satoshi Kiyama MD Masaru Yamashita MD, PhD |
| author_facet | Hiroyuki Iuchi MD, PhD Junichiro Ohori MD, PhD Hisahiro Matsuzaki MD Satoshi Kiyama MD Masaru Yamashita MD, PhD |
| author_sort | Hiroyuki Iuchi MD, PhD |
| collection | DOAJ |
| description | Objective To determine whether the modified Glasgow prognostic score (mGPS) and high-sensitivity mGPS (HS-mGPS) could predict outcomes among patients with hypopharyngeal squamous cell carcinoma (HSCC). Study Design Retrospective cohort study. Setting Affiliated university hospital. Methods We reviewed the records of 115 patients with histologically confirmed HSCC between March 2007 and December 2019. Univariate and multivariable Cox proportional hazard analyses were performed for overall survival (OS) and disease-free survival (DFS). Results The 5-year OS rates were 84.0% for the mGPS0 group, 47.8% for the mGPS1 group, and 17.9% for the mGPS2 group ( P < .0001), while the 5-year OS rates were 86.7% for the HS-mGPS0 group, 69.0% for the HS-mGPS1 group, and 22.2% for the HS-mGPS2 group ( P < .001). The mGPS and HS-mGPS were both associated with OS in the univariate analyses, although only the HS-mGPS was independently associated with OS (hazard ratio, 2.68 [95% CI, 1.19-6.05]; P < .05). The 5-year DFS rates were 75.8% for the mGPS0 group, 53.0% for the mGPS1 group, and 13.8% for the mGPS2 group ( P < .001), while the 5-year DFS rates were 79.8% for the HS-mGPS0 group, 56.8% for the HS-mGPS1 group, and 11.6% for the HS-mGPS2 group ( P < .001). The mGPS and HS-mGPS were both associated with DFS in the univariate analyses, although only the HS-mGPS was independently associated with DFS (hazard ratio, 2.35 [95% CI, 1.03-5.37]; P < .05). Conclusion Our study suggests that the HS-mGPS is useful as prognostic factor in HSCC. |
| first_indexed | 2024-03-11T14:04:09Z |
| format | Article |
| id | doaj.art-4b03fefc14f54d47b0f6479ad2f6c333 |
| institution | Directory Open Access Journal |
| issn | 2473-974X |
| language | English |
| last_indexed | 2024-03-11T14:04:09Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | OTO Open |
| spelling | doaj.art-4b03fefc14f54d47b0f6479ad2f6c3332023-11-02T03:16:09ZengWileyOTO Open2473-974X2021-12-01510.1177/2473974X211067423Utility of the Modified and High-Sensitivity Modified Glasgow Prognostic Scores for Hypopharyngeal Squamous Cell CarcinomaHiroyuki Iuchi MD, PhD0Junichiro Ohori MD, PhD1Hisahiro Matsuzaki MD2Satoshi Kiyama MD3Masaru Yamashita MD, PhD4Department of Otolaryngology–Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, JapanDepartment of Otolaryngology–Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, JapanDepartment of Otolaryngology–Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, JapanDepartment of Otolaryngology–Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, JapanDepartment of Otolaryngology–Head and Neck Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, JapanObjective To determine whether the modified Glasgow prognostic score (mGPS) and high-sensitivity mGPS (HS-mGPS) could predict outcomes among patients with hypopharyngeal squamous cell carcinoma (HSCC). Study Design Retrospective cohort study. Setting Affiliated university hospital. Methods We reviewed the records of 115 patients with histologically confirmed HSCC between March 2007 and December 2019. Univariate and multivariable Cox proportional hazard analyses were performed for overall survival (OS) and disease-free survival (DFS). Results The 5-year OS rates were 84.0% for the mGPS0 group, 47.8% for the mGPS1 group, and 17.9% for the mGPS2 group ( P < .0001), while the 5-year OS rates were 86.7% for the HS-mGPS0 group, 69.0% for the HS-mGPS1 group, and 22.2% for the HS-mGPS2 group ( P < .001). The mGPS and HS-mGPS were both associated with OS in the univariate analyses, although only the HS-mGPS was independently associated with OS (hazard ratio, 2.68 [95% CI, 1.19-6.05]; P < .05). The 5-year DFS rates were 75.8% for the mGPS0 group, 53.0% for the mGPS1 group, and 13.8% for the mGPS2 group ( P < .001), while the 5-year DFS rates were 79.8% for the HS-mGPS0 group, 56.8% for the HS-mGPS1 group, and 11.6% for the HS-mGPS2 group ( P < .001). The mGPS and HS-mGPS were both associated with DFS in the univariate analyses, although only the HS-mGPS was independently associated with DFS (hazard ratio, 2.35 [95% CI, 1.03-5.37]; P < .05). Conclusion Our study suggests that the HS-mGPS is useful as prognostic factor in HSCC.https://doi.org/10.1177/2473974X211067423 |
| spellingShingle | Hiroyuki Iuchi MD, PhD Junichiro Ohori MD, PhD Hisahiro Matsuzaki MD Satoshi Kiyama MD Masaru Yamashita MD, PhD Utility of the Modified and High-Sensitivity Modified Glasgow Prognostic Scores for Hypopharyngeal Squamous Cell Carcinoma OTO Open |
| title | Utility of the Modified and High-Sensitivity Modified Glasgow Prognostic Scores for Hypopharyngeal Squamous Cell Carcinoma |
| title_full | Utility of the Modified and High-Sensitivity Modified Glasgow Prognostic Scores for Hypopharyngeal Squamous Cell Carcinoma |
| title_fullStr | Utility of the Modified and High-Sensitivity Modified Glasgow Prognostic Scores for Hypopharyngeal Squamous Cell Carcinoma |
| title_full_unstemmed | Utility of the Modified and High-Sensitivity Modified Glasgow Prognostic Scores for Hypopharyngeal Squamous Cell Carcinoma |
| title_short | Utility of the Modified and High-Sensitivity Modified Glasgow Prognostic Scores for Hypopharyngeal Squamous Cell Carcinoma |
| title_sort | utility of the modified and high sensitivity modified glasgow prognostic scores for hypopharyngeal squamous cell carcinoma |
| url | https://doi.org/10.1177/2473974X211067423 |
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