Current research progress of local drug delivery systems based on biodegradable polymers in treating chronic osteomyelitis
Chronic osteomyelitis is one of the most challenging diseases in orthopedic treatment. It is usually treated with intravenous antibiotics and debridement in clinical practice, which also brings systemic drug side effects and bone defects. The local drug delivery system of antibiotics has the charact...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1042128/full |
| _version_ | 1798015777104723968 |
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| author | Yixiu Liu Yixiu Liu Xu Li Xu Li A. Liang A. Liang |
| author_facet | Yixiu Liu Yixiu Liu Xu Li Xu Li A. Liang A. Liang |
| author_sort | Yixiu Liu |
| collection | DOAJ |
| description | Chronic osteomyelitis is one of the most challenging diseases in orthopedic treatment. It is usually treated with intravenous antibiotics and debridement in clinical practice, which also brings systemic drug side effects and bone defects. The local drug delivery system of antibiotics has the characteristics of targeted slow release to the lesion site, replacing systemic antibiotics and reducing the toxic and side effects of drugs. It can also increase the local drug concentration, achieve sound bacteriostatic effects, and promote bone healing and formation. Currently, PMMA beads are used in treating chronic osteomyelitis at home and abroad, but the chain beads need to be removed after a second operation, inconveniences patients. Biodegradable materials have been extensively studied as optimal options for antibiotic encapsulation and delivery, bringing new hope for treating chronic osteomyelitis. This article reviews the research progress of local drug delivery systems based on biodegradable polymers, including natural and synthetic ones, in treating chronic osteomyelitis. |
| first_indexed | 2024-04-11T15:40:14Z |
| format | Article |
| id | doaj.art-4b05197a55d041c481c7201c007499d6 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-11T15:40:14Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-4b05197a55d041c481c7201c007499d62022-12-22T04:15:51ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-11-011010.3389/fbioe.2022.10421281042128Current research progress of local drug delivery systems based on biodegradable polymers in treating chronic osteomyelitisYixiu Liu0Yixiu Liu1Xu Li2Xu Li3A. Liang4A. Liang5Department of Orthopaedics, The Central Hospital Affiliated to Shenyang Medical College, Shenyang, ChinaShenyang Clinical Research Center for Hand and Foot, Shenyang, ChinaDepartment of Orthopaedics, The Central Hospital Affiliated to Shenyang Medical College, Shenyang, ChinaShenyang Clinical Research Center for Hand and Foot, Shenyang, ChinaDepartment of Orthopaedics, The Central Hospital Affiliated to Shenyang Medical College, Shenyang, ChinaShenyang Clinical Research Center for Hand and Foot, Shenyang, ChinaChronic osteomyelitis is one of the most challenging diseases in orthopedic treatment. It is usually treated with intravenous antibiotics and debridement in clinical practice, which also brings systemic drug side effects and bone defects. The local drug delivery system of antibiotics has the characteristics of targeted slow release to the lesion site, replacing systemic antibiotics and reducing the toxic and side effects of drugs. It can also increase the local drug concentration, achieve sound bacteriostatic effects, and promote bone healing and formation. Currently, PMMA beads are used in treating chronic osteomyelitis at home and abroad, but the chain beads need to be removed after a second operation, inconveniences patients. Biodegradable materials have been extensively studied as optimal options for antibiotic encapsulation and delivery, bringing new hope for treating chronic osteomyelitis. This article reviews the research progress of local drug delivery systems based on biodegradable polymers, including natural and synthetic ones, in treating chronic osteomyelitis.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1042128/fullchronic osteomyelitislocal drug delivery systemssynthetic biodegradable polymersnatural biodegradable polymersmicro/nanoparticles |
| spellingShingle | Yixiu Liu Yixiu Liu Xu Li Xu Li A. Liang A. Liang Current research progress of local drug delivery systems based on biodegradable polymers in treating chronic osteomyelitis Frontiers in Bioengineering and Biotechnology chronic osteomyelitis local drug delivery systems synthetic biodegradable polymers natural biodegradable polymers micro/nanoparticles |
| title | Current research progress of local drug delivery systems based on biodegradable polymers in treating chronic osteomyelitis |
| title_full | Current research progress of local drug delivery systems based on biodegradable polymers in treating chronic osteomyelitis |
| title_fullStr | Current research progress of local drug delivery systems based on biodegradable polymers in treating chronic osteomyelitis |
| title_full_unstemmed | Current research progress of local drug delivery systems based on biodegradable polymers in treating chronic osteomyelitis |
| title_short | Current research progress of local drug delivery systems based on biodegradable polymers in treating chronic osteomyelitis |
| title_sort | current research progress of local drug delivery systems based on biodegradable polymers in treating chronic osteomyelitis |
| topic | chronic osteomyelitis local drug delivery systems synthetic biodegradable polymers natural biodegradable polymers micro/nanoparticles |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1042128/full |
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