Evaluation of Using IVMagnesium Sulfate forPrevention of PostoperativeAtrial Fibrillation Arrhythmiain Patients UndergoingCoronary Artery BypassGrafting
Introduction & Objective: Atrial fibrillation (AF) is the most common important arrhythmia of cardiac surgery. Magnesium, like several other pharmacologic agents, has been used in the prophylaxis of postoperative AF with varying degrees of success. The purpose of this study was to determine the...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Yasuj University Of Medical Sciences
2008-07-01
|
| Series: | Armaghane Danesh Bimonthly Journal |
| Subjects: | |
| Online Access: | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-39-21&slc_lang=en&sid=1 |
| Summary: | Introduction & Objective: Atrial fibrillation (AF) is the most
common important arrhythmia of cardiac surgery. Magnesium, like
several other pharmacologic agents, has been used in the
prophylaxis of postoperative AF with varying degrees of success.
The purpose of this study was to determine the effect of
magnesium administration in reducing postoperative AF after
cardiac surgery.
Materials & Methods: In a double blind randomized clinical trial,
over an 18-month period, 162 patients that electively scheduled for
coronary artery bypass graft (CABG) surgery involving
cardiopulmonary bypass were studied. The patients were randomly
assigned to magnesium receiving (n=81) and placebo (n=81)
groups. In magnesium group, the patients were received an
intravenous infusion of magnesium sulfate, 2 g, immediately after
the termination of cardiopulmonary bypass. Total serum
magnesium concentration was measured before induction,
immediately after operation (before magnesium infusion), and 24
hr after ICU admission. AF was sought with a 12-lead
electrocardiogram (ECG) from the end of surgery up till 72 hr after
operation.
Results: AF occurrence in magnesium group (7.4%) was lower
than placebo group (34.6%) and the differences were statistically
significant (p<0.0001). There was no significant difference in serum
magnesium level during the follow-up. In patients with AF, the
serum magnesium concentration before operation was significantly
lower than others (p=0.0001). In all patients, the serum magnesium
was decreased immediately after operation (p<0.0001).
Conclusion: This study showed that hypomagnesemia is a
common finding after postoperative cardiac surgery and it is
associated with post operation AF. The use of magnesium in early
postoperative periods is highly effective in reducing the incidence
of AF after coronary artery bypass grafting |
|---|---|
| ISSN: | 1728-6506 1728-6514 |