Apigenin attenuates visceral hypersensitivity in water avoidance stress rats by modulating the microbiota-gut-brain axis and inhibiting mast cell activation

Apigenin attenuates visceral hypersensitivity in water avoidance stress rats by modulating the microbiota-gut-brain axis and inhibiting mast cell activation

Visceral hypersensitivity (VH) and gut microbiota dysbiosis significantly contribute to the occurrence and development of irritable bowel syndrome (IBS), exacerbated by stress. Apigenin, a natural flavonoid derived from plants, possesses a range of beneficial properties. However, additional research...

Full description

Bibliographic Details
Main Authors:	Yuan Xia, Shuai Peng, Mengjuan Lin, Houyu Duan, Fangting Yuan, Ming Shao, Wei Tan, Hesheng Luo
Format:	Article
Language:	English
Published:	Elsevier 2023-11-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Irritable bowel syndrome Visceral hypersensitivity Apigenin Gut-brain axis Mast cell Toll-like receptors
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332223013604

Similar Items

Electroacupuncture Attenuates Post-Inflammatory IBS-Associated Visceral and Somatic Hypersensitivity and Correlates With the Regulatory Mechanism of Epac1–Piezo2 Axis
by: Jing Guo, et al.
Published: (2022-07-01)

Low FODMAP Diet Relieves Visceral Hypersensitivity and Is Associated with Changes in Colonic Microcirculation in Water Avoidance Mice Model
by: Chenmin Hu, et al.
Published: (2023-02-01)

The Importance of Visceral Hypersensitivity in Irritable Bowel Syndrome—Plant Metabolites in IBS Treatment
by: Ewa Dudzińska, et al.
Published: (2023-10-01)

The efficacy and neural mechanism of acupuncture therapy in the treatment of visceral hypersensitivity in irritable bowel syndrome
by: Yuanzhen Yang, et al.
Published: (2023-09-01)

Clostridium butyricum relieve the visceral hypersensitivity in mice induced by Citrobacter rodentium infection with chronic stress
by: Tengfei Wang, et al.
Published: (2021-06-01)

Local Colonic Administration of a Serine Protease Inhibitor Improves Post-Inflammatory Visceral Hypersensitivity in Rats
by: Nikita Hanning, et al.
Published: (2021-05-01)

Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation
by: Ziyang Chen, et al.
Published: (2023-11-01)

Spirocyclopiperazinium salt compound DXL-A-24 improves visceral sensation and gut microbiota in a rat model of irritable bowel syndrome
by: Yan Xu, et al.
Published: (2023-06-01)

Gut–Brain Axis, Microbiota and Probiotics—Current Knowledge on Their Role in Irritable Bowel Syndrome: A Review
by: Cristina Maria Marginean, et al.
Published: (2023-11-01)

Diet–microbial cross–talk underlying increased visceral perception
by: Giada De Palma, et al.
Published: (2023-12-01)

Deepening the Mechanisms of Visceral Pain Persistence: An Evaluation of the Gut-Spinal Cord Relationship
by: Elena Lucarini, et al.
Published: (2020-07-01)

Comparing the effect of internet-delivered short-term progressive muscle relaxation and psychoeducation on mindful ability, visceral hypersensitivity and symptoms of patients with irritable bowel syndrome
by: Fatemeh Zargar, et al.
Published: (2023-01-01)

Apigenin reduces the suppressive effect of exosomes derived from irritable bowel syndrome patients on the autophagy of human colon epithelial cells by promoting ATG14
by: Rui Fu, et al.
Published: (2023-03-01)

Role of anxiety in the pathophysiology of irritable bowel syndrome: importance of the amygdala
by: Brent Myers, et al.
Published: (2009-06-01)

No synergistic effect of fecal microbiota transplantation and shugan decoction in water avoidance stress-induced IBS-D rat model
by: Yangyang Meng, et al.
Published: (2022-09-01)

Up-regulation of HTR1A reverses stress-induced visceral hypersensitivity through modulating interactions among the anterior cingulate cortex, insular cortex and hippocampus
by: Xuan Liqian, et al.
Published: (2020-10-01)

The modern ideas about the etiology of irritable bowel syndrome
by: G. M. Sakhautdinova, et al.
Published: (2019-05-01)

A Survey of Methodologies for Assessing Mast Cell Density and Activation in Patients with Functional Abdominal Pain Disorders
by: Hunter Friesen, et al.
Published: (2021-09-01)

Role of the nuclear receptor subfamily 4a in mast cells in the development of irritable bowel syndrome
by: Ruidi Li, et al.
Published: (2022-01-01)

Early life stress induces irritable bowel syndrome from childhood to adulthood in mice
by: Enfu Tao, et al.
Published: (2023-10-01)

Estrogens Play a Critical Role in Stress-Related Gastrointestinal Dysfunction in a Spontaneous Model of Disorders of Gut–Brain Interaction
by: Alison Accarie, et al.
Published: (2022-04-01)

Metabolomics: The Key to Unraveling the Role of the Microbiome in Visceral Pain Neurotransmission
by: Adam Shute, et al.
Published: (2022-06-01)

Global research progress of visceral hypersensitivity and irritable bowel syndrome: bibliometrics and visualized analysis
by: Siyu Tian, et al.
Published: (2023-05-01)

Mast Cell Regulation and Irritable Bowel Syndrome: Effects of Food Components with Potential Nutraceutical Use
by: José Antonio Uranga, et al.
Published: (2020-09-01)

Translation and validation of the Ukrainian version of the visceral sensitivity index for patients with irritable bowel syndrome
by: Artem Neverovskyi, et al.
Published: (2023-09-01)

Characteristics of gut microbiota in male periadolescent rats with irritable bowel syndrome
by: Wei Lin, et al.
Published: (2023-08-01)

Current Treatment Options and Therapeutic Insights for Gastrointestinal Dysmotility and Functional Gastrointestinal Disorders
by: Rajan Singh, et al.
Published: (2022-01-01)

Research hotspots and trend analysis of abdominal pain in inflammatory bowel disease: a bibliometric and visualized analysis
by: Shuai Peng, et al.
Published: (2023-09-01)

Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and literature review)
by: V. T. Ivashkin, et al.
Published: (2022-05-01)

Integrated omics analysis reveals the epigenetic mechanism of visceral hypersensitivity in IBS-D
by: Yaoyao Lu, et al.
Published: (2023-03-01)

Editorial: Neuroendocrine signalling pathways along the microbiota-gut-brain axis in functional gut disorders
by: Maria Cecilia Giron, et al.
Published: (2022-09-01)

Visceral sensitivity index of patients with irritable bowel syndrome after COVID-19 infection
by: Iana Yu. Feklina, et al.
Published: (2022-07-01)

Quaternary ammonium compounds in hypersensitivity reactions
by: Marine Peyneau, et al.
Published: (2022-09-01)

A Challenge for Allergologist: Application of Allergy Diagnostic Methods in Mast Cell Disorders
by: Jan Romantowski, et al.
Published: (2021-02-01)

Brain–Gut–Microbiota Axis
by: Ayoung Lee, et al.
Published: (2023-04-01)

The effects of Saccharomyces boulardii on rat colonic hypermotility induced by repeated water avoidance stress and the potential mechanism
by: Jingwen Liu, et al.
Published: (2022-11-01)

Brain-gut axis dysfunction in young athlete with unfulfilled dreams - irritable bowel syndrome
by: Karlo Tkalec, et al.
Published: (2023-01-01)

Microglia-derived TNF-α inhibiting GABAergic neurons in the anterior lateral bed nucleus of the stria terminalis precipitates visceral hypersensitivity induced by colorectal distension in rats
by: Ning-Ning Ji, et al.
Published: (2022-05-01)

Tryptase activates enteric glial cells followed by affecting neuronal properties possibly via the stimuli-associated mediators
by: Kazunari Tominaga, et al.
Published: (2023-04-01)

How to improve effectiveness of treatment of patients with irritable bowel syndrome?
by: E. V. Golovanova
Published: (2021-05-01)