Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset
<p>Abstract</p> <p>Background</p> <p>When selecting mates, many vertebrate species seek partners with major histocompatibility complex (MHC) genes different from their own, presumably in response to selective pressure against inbreeding and towards MHC diversity. Attemp...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-11-01
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| Series: | BMC Genomics |
| Online Access: | http://www.biomedcentral.com/1471-2164/11/626 |
| _version_ | 1818787286378086400 |
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| author | Hauser Stephen L Santaniello Adam Caillier Stacy J Gourraud Pierre-Antoine Khankhanian Pouya Baranzini Sergio E Oksenberg Jorge R |
| author_facet | Hauser Stephen L Santaniello Adam Caillier Stacy J Gourraud Pierre-Antoine Khankhanian Pouya Baranzini Sergio E Oksenberg Jorge R |
| author_sort | Hauser Stephen L |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>When selecting mates, many vertebrate species seek partners with major histocompatibility complex (MHC) genes different from their own, presumably in response to selective pressure against inbreeding and towards MHC diversity. Attempts at replication of these genetic results in human studies, however, have reached conflicting conclusions.</p> <p>Results</p> <p>Using a multi-analytical strategy, we report validated genome-wide relationships between genetic identity and human mate choice in 930 couples of European ancestry. We found significant similarity between spouses in the MHC at class I region in chromosome 6p21, and at the odorant receptor family 13 locus in chromosome 9. Conversely, there was significant dissimilarity in the MHC class II region, near the <it>HLA-DQA1 </it>and -<it>DQB1 </it>genes. We also found that genomic regions with significant similarity between spouses show excessive homozygosity in the general population (assessed in the HapMap CEU dataset). Conversely, loci that were significantly dissimilar among spouses were more likely to show excessive heterozygosity in the general population.</p> <p>Conclusions</p> <p>This study highlights complex patterns of genomic identity among partners in unrelated couples, consistent with a multi-faceted role for genetic factors in mate choice behavior in human populations.</p> |
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| id | doaj.art-4b07b4cbc791481db578403bbbe868b5 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-18T14:05:22Z |
| publishDate | 2010-11-01 |
| publisher | BMC |
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| series | BMC Genomics |
| spelling | doaj.art-4b07b4cbc791481db578403bbbe868b52022-12-21T21:05:15ZengBMCBMC Genomics1471-21642010-11-0111162610.1186/1471-2164-11-626Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis datasetHauser Stephen LSantaniello AdamCaillier Stacy JGourraud Pierre-AntoineKhankhanian PouyaBaranzini Sergio EOksenberg Jorge R<p>Abstract</p> <p>Background</p> <p>When selecting mates, many vertebrate species seek partners with major histocompatibility complex (MHC) genes different from their own, presumably in response to selective pressure against inbreeding and towards MHC diversity. Attempts at replication of these genetic results in human studies, however, have reached conflicting conclusions.</p> <p>Results</p> <p>Using a multi-analytical strategy, we report validated genome-wide relationships between genetic identity and human mate choice in 930 couples of European ancestry. We found significant similarity between spouses in the MHC at class I region in chromosome 6p21, and at the odorant receptor family 13 locus in chromosome 9. Conversely, there was significant dissimilarity in the MHC class II region, near the <it>HLA-DQA1 </it>and -<it>DQB1 </it>genes. We also found that genomic regions with significant similarity between spouses show excessive homozygosity in the general population (assessed in the HapMap CEU dataset). Conversely, loci that were significantly dissimilar among spouses were more likely to show excessive heterozygosity in the general population.</p> <p>Conclusions</p> <p>This study highlights complex patterns of genomic identity among partners in unrelated couples, consistent with a multi-faceted role for genetic factors in mate choice behavior in human populations.</p>http://www.biomedcentral.com/1471-2164/11/626 |
| spellingShingle | Hauser Stephen L Santaniello Adam Caillier Stacy J Gourraud Pierre-Antoine Khankhanian Pouya Baranzini Sergio E Oksenberg Jorge R Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset BMC Genomics |
| title | Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset |
| title_full | Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset |
| title_fullStr | Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset |
| title_full_unstemmed | Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset |
| title_short | Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset |
| title_sort | genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset |
| url | http://www.biomedcentral.com/1471-2164/11/626 |
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