The Prognostic Value of Natriuretic Peptides in Stable Patients with Suspected Acute Myocarditis: A Retrospective Study
Risk stratification in acute myocarditis is based on the clinical signs of heart failure, the degree of cardiac dysfunction, and the findings in cardiac magnetic resonance (CMR). The aim of the current study is to examine the prognostic yield of the natriuretic peptide N-terminal-pro hormone Brain N...
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MDPI AG
2022-04-01
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Online Access: | https://www.mdpi.com/2077-0383/11/9/2472 |
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author | Gassan Moady Shahar Perlmutter Shaul Atar |
author_facet | Gassan Moady Shahar Perlmutter Shaul Atar |
author_sort | Gassan Moady |
collection | DOAJ |
description | Risk stratification in acute myocarditis is based on the clinical signs of heart failure, the degree of cardiac dysfunction, and the findings in cardiac magnetic resonance (CMR). The aim of the current study is to examine the prognostic yield of the natriuretic peptide N-terminal-pro hormone Brain Natriuretic Peptide (NT-proBNP) and C-reactive protein (CRP) in acute myocarditis among patients with preserved/mildly reduced left ventricular ejection fraction (LVEF). We retrospectively analyzed 59 patients (median age 28 years, 76% males) with ICD-9 discharge diagnosis of acute myocarditis. Basic characteristics, echocardiographic, and laboratory parameters were obtained from computerized files. The median length of stay was 3, (IQR 2–5) days, and the median LVEF was 48% (IQR, 54–62%). High levels of NT-proBNP and CRP were associated with increased length of stay (r = 0.57, <i>p</i> < 0.001; r = 0.4 <i>p</i> = 0.001, respectively), while troponin level was not (r = 0.068, <i>p</i> = 0.61). During the index hospitalization, complications occurred in 14 (23.7%) patients. High NT-proBNP and CRP levels were associated with complications (<i>p</i> < 0.001, and <i>p</i> = 0.001, respectively), while troponin level was not (<i>p</i> = 0.452). In conclusion, routine measurement of NT-proBNP and CRP are preferred over troponin for risk stratification in hemodynamically stable myocarditis. |
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spelling | doaj.art-4b07dd37eeb54d31aa0fdf73f3f364ea2023-11-23T08:32:49ZengMDPI AGJournal of Clinical Medicine2077-03832022-04-01119247210.3390/jcm11092472The Prognostic Value of Natriuretic Peptides in Stable Patients with Suspected Acute Myocarditis: A Retrospective StudyGassan Moady0Shahar Perlmutter1Shaul Atar2Department of Cardiology, Galilee Medical Center, 1 Ben Tzvi Blvd, Nahariya 2210001, IsraelAzrieli Faculty of Medicine, Bar Ilan University, Safed 5290002, IsraelDepartment of Cardiology, Galilee Medical Center, 1 Ben Tzvi Blvd, Nahariya 2210001, IsraelRisk stratification in acute myocarditis is based on the clinical signs of heart failure, the degree of cardiac dysfunction, and the findings in cardiac magnetic resonance (CMR). The aim of the current study is to examine the prognostic yield of the natriuretic peptide N-terminal-pro hormone Brain Natriuretic Peptide (NT-proBNP) and C-reactive protein (CRP) in acute myocarditis among patients with preserved/mildly reduced left ventricular ejection fraction (LVEF). We retrospectively analyzed 59 patients (median age 28 years, 76% males) with ICD-9 discharge diagnosis of acute myocarditis. Basic characteristics, echocardiographic, and laboratory parameters were obtained from computerized files. The median length of stay was 3, (IQR 2–5) days, and the median LVEF was 48% (IQR, 54–62%). High levels of NT-proBNP and CRP were associated with increased length of stay (r = 0.57, <i>p</i> < 0.001; r = 0.4 <i>p</i> = 0.001, respectively), while troponin level was not (r = 0.068, <i>p</i> = 0.61). During the index hospitalization, complications occurred in 14 (23.7%) patients. High NT-proBNP and CRP levels were associated with complications (<i>p</i> < 0.001, and <i>p</i> = 0.001, respectively), while troponin level was not (<i>p</i> = 0.452). In conclusion, routine measurement of NT-proBNP and CRP are preferred over troponin for risk stratification in hemodynamically stable myocarditis.https://www.mdpi.com/2077-0383/11/9/2472myocarditisventricular functionnatriuretic peptiderisk stratification |
spellingShingle | Gassan Moady Shahar Perlmutter Shaul Atar The Prognostic Value of Natriuretic Peptides in Stable Patients with Suspected Acute Myocarditis: A Retrospective Study Journal of Clinical Medicine myocarditis ventricular function natriuretic peptide risk stratification |
title | The Prognostic Value of Natriuretic Peptides in Stable Patients with Suspected Acute Myocarditis: A Retrospective Study |
title_full | The Prognostic Value of Natriuretic Peptides in Stable Patients with Suspected Acute Myocarditis: A Retrospective Study |
title_fullStr | The Prognostic Value of Natriuretic Peptides in Stable Patients with Suspected Acute Myocarditis: A Retrospective Study |
title_full_unstemmed | The Prognostic Value of Natriuretic Peptides in Stable Patients with Suspected Acute Myocarditis: A Retrospective Study |
title_short | The Prognostic Value of Natriuretic Peptides in Stable Patients with Suspected Acute Myocarditis: A Retrospective Study |
title_sort | prognostic value of natriuretic peptides in stable patients with suspected acute myocarditis a retrospective study |
topic | myocarditis ventricular function natriuretic peptide risk stratification |
url | https://www.mdpi.com/2077-0383/11/9/2472 |
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