Experimental Study: Interleukin-31 Augments Morphine-Induced Antinociceptive Activity and Suppress Tolerance Development in Mice

Experimental Study: Interleukin-31 Augments Morphine-Induced Antinociceptive Activity and Suppress Tolerance Development in Mice

Morphine-induced antinociception is partially reduced in interleukin-31 (IL-31) receptor A (IL-31RA)-deficient mice, indicating that IL-31RA is crucial for morphine-induced peripheral antinociception. Herein, we examined the combined effects of IL-31 and morphine on the antinociceptive activity and...

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Bibliographic Details
Main Authors:	Iwao Arai, Minoru Tsuji, Saburo Saito, Hiroshi Takeda
Format:	Article
Language:	English
Published:	MDPI AG 2023-11-01
Series:	International Journal of Molecular Sciences
Subjects:	analgesia antinociception interleukin-31 (IL-31) interleukin receptor A (IL-31RA) IL-31 receptor A-deficient (IL-31RAKI) mice itch
Online Access:	https://www.mdpi.com/1422-0067/24/22/16548

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