Polyphenol-rich Trapa quadrispinosa pericarp extract ameliorates high-fat diet induced non-alcoholic fatty liver disease by regulating lipid metabolism and insulin resistance in mice
In China, Trapa quadrispinosa (also called water caltrop) has long been used as a function food and folk medicine to treat diabetes mellitus for years. In the present study, the extract of T. quadrispinosa pericarp (TQPE) which mainly contains hydrolysable tannins was prepared to investigate the pot...
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PeerJ Inc.
2019-11-01
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author | Tunyu Jian Han Lü Xiaoqin Ding Yuexian Wu Yuanyuan Zuo Jiawei Li Jian Chen Hong Gu |
author_facet | Tunyu Jian Han Lü Xiaoqin Ding Yuexian Wu Yuanyuan Zuo Jiawei Li Jian Chen Hong Gu |
author_sort | Tunyu Jian |
collection | DOAJ |
description | In China, Trapa quadrispinosa (also called water caltrop) has long been used as a function food and folk medicine to treat diabetes mellitus for years. In the present study, the extract of T. quadrispinosa pericarp (TQPE) which mainly contains hydrolysable tannins was prepared to investigate the potential therapeutic action in non-alcoholic fatty liver disease (NAFLD) mice induced by high fat-diet (HFD). After the administration of TQPE (15, 30 mg/kg/day) for 8 weeks, the increased weight of body and liver were significantly suppressed. TQPE also ameliorated liver lipid deposition and reduced lipids parameters of blood in mice. Moreover, TQPE attenuated oxidative stress and showed a hepatoprotective effect in mice. TQPE was also found to decrease the value of homeostatic model assessment for insulin resistance. In addition, TQPE administration increased the phosphorylation of AMP-activated protein kinase (AMPK) and Acetyl-CoA carboxylase (ACC) and inhibited sterol regulatory element-binding protein (SREBP) in the liver tissue. Meanwhile, TQPE elevated insulin receptor substrate-1 (IRs-1) and protein kinase B (Akt) phosphorylation. These results reflected that, as a nature product, TQPE is a potential agent for suppressing the process of NAFLD via regulation of the AMPK/SREBP/ACC and IRs-1/Akt pathways. |
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issn | 2167-8359 |
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last_indexed | 2024-03-09T06:53:02Z |
publishDate | 2019-11-01 |
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spelling | doaj.art-4b08f66375234038af044ae8b9c916322023-12-03T10:15:00ZengPeerJ Inc.PeerJ2167-83592019-11-017e816510.7717/peerj.8165Polyphenol-rich Trapa quadrispinosa pericarp extract ameliorates high-fat diet induced non-alcoholic fatty liver disease by regulating lipid metabolism and insulin resistance in miceTunyu Jian0Han Lü1Xiaoqin Ding2Yuexian Wu3Yuanyuan Zuo4Jiawei Li5Jian Chen6Hong Gu7Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, ChinaInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, ChinaInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, ChinaInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, ChinaInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, ChinaInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, ChinaInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, ChinaDepartment of Colorectal Surgery, Jiangyin Hospital of Traditional Chinese Medicine, Jiangyin, ChinaIn China, Trapa quadrispinosa (also called water caltrop) has long been used as a function food and folk medicine to treat diabetes mellitus for years. In the present study, the extract of T. quadrispinosa pericarp (TQPE) which mainly contains hydrolysable tannins was prepared to investigate the potential therapeutic action in non-alcoholic fatty liver disease (NAFLD) mice induced by high fat-diet (HFD). After the administration of TQPE (15, 30 mg/kg/day) for 8 weeks, the increased weight of body and liver were significantly suppressed. TQPE also ameliorated liver lipid deposition and reduced lipids parameters of blood in mice. Moreover, TQPE attenuated oxidative stress and showed a hepatoprotective effect in mice. TQPE was also found to decrease the value of homeostatic model assessment for insulin resistance. In addition, TQPE administration increased the phosphorylation of AMP-activated protein kinase (AMPK) and Acetyl-CoA carboxylase (ACC) and inhibited sterol regulatory element-binding protein (SREBP) in the liver tissue. Meanwhile, TQPE elevated insulin receptor substrate-1 (IRs-1) and protein kinase B (Akt) phosphorylation. These results reflected that, as a nature product, TQPE is a potential agent for suppressing the process of NAFLD via regulation of the AMPK/SREBP/ACC and IRs-1/Akt pathways.https://peerj.com/articles/8165.pdfPolyphenolTrapa quadrispinosa pericarpNon-alcoholic fatty liver diseaseHigh-fat dietAMPK/SREBP/ACCIRs-1/Akt |
spellingShingle | Tunyu Jian Han Lü Xiaoqin Ding Yuexian Wu Yuanyuan Zuo Jiawei Li Jian Chen Hong Gu Polyphenol-rich Trapa quadrispinosa pericarp extract ameliorates high-fat diet induced non-alcoholic fatty liver disease by regulating lipid metabolism and insulin resistance in mice PeerJ Polyphenol Trapa quadrispinosa pericarp Non-alcoholic fatty liver disease High-fat diet AMPK/SREBP/ACC IRs-1/Akt |
title | Polyphenol-rich Trapa quadrispinosa pericarp extract ameliorates high-fat diet induced non-alcoholic fatty liver disease by regulating lipid metabolism and insulin resistance in mice |
title_full | Polyphenol-rich Trapa quadrispinosa pericarp extract ameliorates high-fat diet induced non-alcoholic fatty liver disease by regulating lipid metabolism and insulin resistance in mice |
title_fullStr | Polyphenol-rich Trapa quadrispinosa pericarp extract ameliorates high-fat diet induced non-alcoholic fatty liver disease by regulating lipid metabolism and insulin resistance in mice |
title_full_unstemmed | Polyphenol-rich Trapa quadrispinosa pericarp extract ameliorates high-fat diet induced non-alcoholic fatty liver disease by regulating lipid metabolism and insulin resistance in mice |
title_short | Polyphenol-rich Trapa quadrispinosa pericarp extract ameliorates high-fat diet induced non-alcoholic fatty liver disease by regulating lipid metabolism and insulin resistance in mice |
title_sort | polyphenol rich trapa quadrispinosa pericarp extract ameliorates high fat diet induced non alcoholic fatty liver disease by regulating lipid metabolism and insulin resistance in mice |
topic | Polyphenol Trapa quadrispinosa pericarp Non-alcoholic fatty liver disease High-fat diet AMPK/SREBP/ACC IRs-1/Akt |
url | https://peerj.com/articles/8165.pdf |
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