The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions
Context: Thyroid cancers are the most common malignancy of the endocrine system. Over-expression of trophoblast cell-surface antigen 2 (TROP-2) in various tumors has been found to correlate with poor prognosis and aggressive tumor behavior. Aims: The aim of this study was to evaluateTROP-2 expressio...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2019;volume=62;issue=2;spage=206;epage=210;aulast=Sadullahoğlu |
| _version_ | 1819274616036655104 |
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| author | Canan Sadullahoğlu Alper Sayıner Dinç Süren Hülya Tosun Yıldırım Döndü Nergiz Cem Sezer Mehmet Tahir Oruç |
| author_facet | Canan Sadullahoğlu Alper Sayıner Dinç Süren Hülya Tosun Yıldırım Döndü Nergiz Cem Sezer Mehmet Tahir Oruç |
| author_sort | Canan Sadullahoğlu |
| collection | DOAJ |
| description | Context: Thyroid cancers are the most common malignancy of the endocrine system. Over-expression of trophoblast cell-surface antigen 2 (TROP-2) in various tumors has been found to correlate with poor prognosis and aggressive tumor behavior. Aims: The aim of this study was to evaluateTROP-2 expression in thyroid neoplasms. Subjects and Methods: This study contained 152 cases, including 48 follicular nodular disease (FND), 29 follicular adenoma (FA), 57 papillary thyroid carcinoma (PTC), 12 follicular thyroid carcinoma (FTC), 3 medullary thyroid carcinoma (MTC), 2 poorly differentiated thyroid carcinoma (PDTC) and 1 undifferentiated thyroid carcinoma (UDTC). TROP-2 expression was investigated via immunohistochemistry in sections prepared from paraffin blocks of the cases. Results: The cases comprised 32 (21%) males and 120 (79%) females with a mean age of 46.8 years (range, 15-85 years). TROP-2 expression was observed in 74.6% of the malignant lesions of the thyroid except for medullary carcinoma, poorly differentiated and undifferentiated thyroid carcinoma. Immunoreactivity was 3.4% in FA, 41.7% of cases with FTC and 81.8% in PTC follicular variant (PTC fv). The difference between FA/FTC and FA/PTC follicular variant were both significant (P < 0.005, P < 0.001, respectively). There was no difference between FTC/PTC fv (P = 0.089). Conclusion: TROP-2 can be considered a useful marker for distinguishing PTC fv cases from follicular nodular disease and follicular adenoma cases because of its high sensitivity in the identification of papillary carcinomas of the thyroid. |
| first_indexed | 2024-12-23T23:11:15Z |
| format | Article |
| id | doaj.art-4b091890f73f42b9b6dcdb3f04e27dc8 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-23T23:11:15Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-4b091890f73f42b9b6dcdb3f04e27dc82022-12-21T17:26:39ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292019-01-0162220621010.4103/IJPM.IJPM_202_18The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesionsCanan SadullahoğluAlper SayınerDinç SürenHülya Tosun YıldırımDöndü NergizCem SezerMehmet Tahir OruçContext: Thyroid cancers are the most common malignancy of the endocrine system. Over-expression of trophoblast cell-surface antigen 2 (TROP-2) in various tumors has been found to correlate with poor prognosis and aggressive tumor behavior. Aims: The aim of this study was to evaluateTROP-2 expression in thyroid neoplasms. Subjects and Methods: This study contained 152 cases, including 48 follicular nodular disease (FND), 29 follicular adenoma (FA), 57 papillary thyroid carcinoma (PTC), 12 follicular thyroid carcinoma (FTC), 3 medullary thyroid carcinoma (MTC), 2 poorly differentiated thyroid carcinoma (PDTC) and 1 undifferentiated thyroid carcinoma (UDTC). TROP-2 expression was investigated via immunohistochemistry in sections prepared from paraffin blocks of the cases. Results: The cases comprised 32 (21%) males and 120 (79%) females with a mean age of 46.8 years (range, 15-85 years). TROP-2 expression was observed in 74.6% of the malignant lesions of the thyroid except for medullary carcinoma, poorly differentiated and undifferentiated thyroid carcinoma. Immunoreactivity was 3.4% in FA, 41.7% of cases with FTC and 81.8% in PTC follicular variant (PTC fv). The difference between FA/FTC and FA/PTC follicular variant were both significant (P < 0.005, P < 0.001, respectively). There was no difference between FTC/PTC fv (P = 0.089). Conclusion: TROP-2 can be considered a useful marker for distinguishing PTC fv cases from follicular nodular disease and follicular adenoma cases because of its high sensitivity in the identification of papillary carcinomas of the thyroid.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2019;volume=62;issue=2;spage=206;epage=210;aulast=SadullahoğluFollicular neoplasmthyroid carcinomaTROP-2 |
| spellingShingle | Canan Sadullahoğlu Alper Sayıner Dinç Süren Hülya Tosun Yıldırım Döndü Nergiz Cem Sezer Mehmet Tahir Oruç The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions Indian Journal of Pathology and Microbiology Follicular neoplasm thyroid carcinoma TROP-2 |
| title | The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions |
| title_full | The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions |
| title_fullStr | The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions |
| title_full_unstemmed | The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions |
| title_short | The diagnostic significance of trophoblast cell-surface antigen-2 expression in benign and malignant thyroid lesions |
| title_sort | diagnostic significance of trophoblast cell surface antigen 2 expression in benign and malignant thyroid lesions |
| topic | Follicular neoplasm thyroid carcinoma TROP-2 |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2019;volume=62;issue=2;spage=206;epage=210;aulast=Sadullahoğlu |
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