The effects of selected inhibitors on human fetal adrenal steroidogenesis differs under basal and ACTH-stimulated conditions

The effects of selected inhibitors on human fetal adrenal steroidogenesis differs under basal and ACTH-stimulated conditions

Abstract Background Disordered fetal adrenal steroidogenesis can cause marked clinical effects including virilization of female fetuses. In postnatal life, adrenal disorders can be life-threatening due to the risk of adrenal crisis and must be carefully managed. However, testing explicit adrenal ste...

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Bibliographic Details
Main Authors: Cecilie Melau, Malene Lundgaard Riis, John E. Nielsen, Signe Perlman, Lene Lundvall, Lea Langhoff Thuesen, Kristine Juul Hare, Mette Schou Hammerum, Rod T. Mitchell, Hanne Frederiksen, Anders Juul, Anne Jørgensen
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Medicine
Subjects:
Human
Adrenal
Ex vivo
Steroid hormones
ACTH
Osilodrostat
Online Access:https://doi.org/10.1186/s12916-021-02080-8

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