Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system.
Female Wistar rats were exposed to filtered air (F) or to concentrated fine particulate matter (P) for 15 days. After mating, the rats were divided into four groups and again exposed to F or P (FF, FP, PF, PP) beginning on day 6 of pregnancy. At embryonic day 19, the placenta was collected. The plac...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5562329?pdf=render |
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| author | Sônia de Fátima Soto Juliana Oliveira de Melo Guilherme D'Aprile Marchesi Karen Lucasechi Lopes Mariana Matera Veras Ivone Braga de Oliveira Regiane Machado de Souza Isac de Castro Luzia Naôko Shinohara Furukawa Paulo Hilário Nascimento Saldiva Joel C Heimann |
| author_facet | Sônia de Fátima Soto Juliana Oliveira de Melo Guilherme D'Aprile Marchesi Karen Lucasechi Lopes Mariana Matera Veras Ivone Braga de Oliveira Regiane Machado de Souza Isac de Castro Luzia Naôko Shinohara Furukawa Paulo Hilário Nascimento Saldiva Joel C Heimann |
| author_sort | Sônia de Fátima Soto |
| collection | DOAJ |
| description | Female Wistar rats were exposed to filtered air (F) or to concentrated fine particulate matter (P) for 15 days. After mating, the rats were divided into four groups and again exposed to F or P (FF, FP, PF, PP) beginning on day 6 of pregnancy. At embryonic day 19, the placenta was collected. The placental structure, the protein and gene expression of TGFβ1, VEGF-A, and its receptor Flk-1 and RAS were evaluated by indirect ELISA and quantitative real-time PCR.Exposure to P decreased the placental mass, size, and surface area as well as the TGFβ1, VEGF-A and Flk-1 content. In the maternal portion of the placenta, angiotensin II (AngII) and its receptors AT1 (AT1R) and AT2 (AT2R) were decreased in the PF and PP groups. In the fetal portion of the placenta, AngII in the FP, PF and PP groups and AT2R in the PF and PP groups were decreased, but AT1R was increased in the FP group. VEGF-A gene expression was lower in the PP group than in the FF group.Exposure to pollutants before and/or during pregnancy alters some characteristics of the placenta, indicating a possible impairment of trophoblast invasion and placental angiogenesis with possible consequences for the maternal-fetal interaction, such as a limitation of fetal nutrition and growth. |
| first_indexed | 2024-12-17T12:45:42Z |
| format | Article |
| id | doaj.art-4b0ae68dc0874e04800c9bdaf0ffdcbf |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T12:45:42Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4b0ae68dc0874e04800c9bdaf0ffdcbf2022-12-21T21:47:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018331410.1371/journal.pone.0183314Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system.Sônia de Fátima SotoJuliana Oliveira de MeloGuilherme D'Aprile MarchesiKaren Lucasechi LopesMariana Matera VerasIvone Braga de OliveiraRegiane Machado de SouzaIsac de CastroLuzia Naôko Shinohara FurukawaPaulo Hilário Nascimento SaldivaJoel C HeimannFemale Wistar rats were exposed to filtered air (F) or to concentrated fine particulate matter (P) for 15 days. After mating, the rats were divided into four groups and again exposed to F or P (FF, FP, PF, PP) beginning on day 6 of pregnancy. At embryonic day 19, the placenta was collected. The placental structure, the protein and gene expression of TGFβ1, VEGF-A, and its receptor Flk-1 and RAS were evaluated by indirect ELISA and quantitative real-time PCR.Exposure to P decreased the placental mass, size, and surface area as well as the TGFβ1, VEGF-A and Flk-1 content. In the maternal portion of the placenta, angiotensin II (AngII) and its receptors AT1 (AT1R) and AT2 (AT2R) were decreased in the PF and PP groups. In the fetal portion of the placenta, AngII in the FP, PF and PP groups and AT2R in the PF and PP groups were decreased, but AT1R was increased in the FP group. VEGF-A gene expression was lower in the PP group than in the FF group.Exposure to pollutants before and/or during pregnancy alters some characteristics of the placenta, indicating a possible impairment of trophoblast invasion and placental angiogenesis with possible consequences for the maternal-fetal interaction, such as a limitation of fetal nutrition and growth.http://europepmc.org/articles/PMC5562329?pdf=render |
| spellingShingle | Sônia de Fátima Soto Juliana Oliveira de Melo Guilherme D'Aprile Marchesi Karen Lucasechi Lopes Mariana Matera Veras Ivone Braga de Oliveira Regiane Machado de Souza Isac de Castro Luzia Naôko Shinohara Furukawa Paulo Hilário Nascimento Saldiva Joel C Heimann Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system. PLoS ONE |
| title | Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system. |
| title_full | Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system. |
| title_fullStr | Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system. |
| title_full_unstemmed | Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system. |
| title_short | Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system. |
| title_sort | exposure to fine particulate matter in the air alters placental structure and the renin angiotensin system |
| url | http://europepmc.org/articles/PMC5562329?pdf=render |
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