Pharmacophore modeling for anti-Chagas drug design using the fragment molecular orbital method.

Pharmacophore modeling for anti-Chagas drug design using the fragment molecular orbital method.

Chagas disease, caused by the parasite Trypanosoma cruzi, is a neglected tropical disease that causes severe human health problems. To develop a new chemotherapeutic agent for the treatment of Chagas disease, we predicted a pharmacophore model for T. cruzi dihydroorotate dehydrogenase (TcDHODH) by f...

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Những tác giả chính: Ryunosuke Yoshino, Nobuaki Yasuo, Daniel Ken Inaoka, Yohsuke Hagiwara, Kazuki Ohno, Masaya Orita, Masayuki Inoue, Tomoo Shiba, Shigeharu Harada, Teruki Honma, Emmanuel Oluwadare Balogun, Josmar Rodrigues da Rocha, Carlos Alberto Montanari, Kiyoshi Kita, Masakazu Sekijima
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Public Library of Science (PLoS) 2015-01-01
Loạt:PLoS ONE
Truy cập trực tuyến:http://europepmc.org/articles/PMC4427443?pdf=render

Internet

http://europepmc.org/articles/PMC4427443?pdf=render

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