| Summary: | The insulin-like growth factor 2 gene (<i>igf2</i>) is thought to be a key factor that could regulate animal growth. In fish, few researchers have reported on the single nucleotide polymorphisms (SNPs) located in <i>igf2</i> and their association with growth traits. We screened the SNPs of <i>igf2</i> from the spotted sea bass (<i>Lateolabrax maculatus</i>) by Sanger sequencing and made an association between these SNPs with growth traits. The full-length complementary (c) DNA of <i>igf2</i> was 1045 bp, including an open reading frame of 648 bp. The amino acid sequence of Igf2 contained a signal peptide, an IGF domain, and an IGF2_C domain. Multiple sequence alignment showed that the IGF domain and IGF2_C domain were conserved in vertebrates. The genome sequence of <i>igf2</i> had a length of 6227 bp. Fourteen SNPs (13 in the introns and one in one of the exons) were found in the genome sequence of <i>igf2</i>. Four SNPs located in the intron were significantly associated with growth traits (<i>p</i> < 0.05). These results demonstrated that these SNPs could be candidate molecular markers for breeding programs in <i>L. maculatus</i>.
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