Case Study: Mapping Evoked Fields in Primary Motor and Sensory Areas via Magnetoencephalography in Tetraplegia
Devices interfacing with the brain through implantation in cortical or subcortical structures have great potential for restoration and rehabilitation in patients with sensory or motor dysfunction. Typical implantation surgeries are planned based on maps of brain activity generated from intact functi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.739693/full |
| _version_ | 1819129597868900352 |
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| author | Stephen T. Foldes Santosh Chandrasekaran Joseph Camerone James Lowe Richard Ramdeo John Ebersole Chad E. Bouton Chad E. Bouton |
| author_facet | Stephen T. Foldes Santosh Chandrasekaran Joseph Camerone James Lowe Richard Ramdeo John Ebersole Chad E. Bouton Chad E. Bouton |
| author_sort | Stephen T. Foldes |
| collection | DOAJ |
| description | Devices interfacing with the brain through implantation in cortical or subcortical structures have great potential for restoration and rehabilitation in patients with sensory or motor dysfunction. Typical implantation surgeries are planned based on maps of brain activity generated from intact function. However, mapping brain activity for planning implantation surgeries is challenging in the target population due to abnormal residual function and, increasingly often, existing MRI-incompatible implanted hardware. Here, we present methods and results for mapping impaired somatosensory and motor function in an individual with paralysis and an existing brain–computer interface (BCI) device. Magnetoencephalography (MEG) was used to directly map the neural activity evoked during transcutaneous electrical stimulation and attempted movement of the impaired hand. Evoked fields were found to align with the expected anatomy and somatotopic organization. This approach may be valuable for guiding implants in other applications, such as cortical stimulation for pain and to improve implant targeting to help reduce the craniotomy size. |
| first_indexed | 2024-12-22T08:46:15Z |
| format | Article |
| id | doaj.art-4b117f104096496c86536dc3d96f76bf |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-22T08:46:15Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-4b117f104096496c86536dc3d96f76bf2022-12-21T18:32:06ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-09-011210.3389/fneur.2021.739693739693Case Study: Mapping Evoked Fields in Primary Motor and Sensory Areas via Magnetoencephalography in TetraplegiaStephen T. Foldes0Santosh Chandrasekaran1Joseph Camerone2James Lowe3Richard Ramdeo4John Ebersole5Chad E. Bouton6Chad E. Bouton7Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, United StatesNeural Bypass and Brain-Computer Interface Laboratory, Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research at Northwell Health, New York, NY, United StatesMEG Center, Overlook Medical Center, Atlantic Health, Summit, NJ, United StatesMEG Center, Overlook Medical Center, Atlantic Health, Summit, NJ, United StatesNeural Bypass and Brain-Computer Interface Laboratory, Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research at Northwell Health, New York, NY, United StatesMEG Center, Overlook Medical Center, Atlantic Health, Summit, NJ, United StatesNeural Bypass and Brain-Computer Interface Laboratory, Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research at Northwell Health, New York, NY, United StatesDepartment of Molecular Medicine, Hofstra-Northwell Medical School, New York, NY, United StatesDevices interfacing with the brain through implantation in cortical or subcortical structures have great potential for restoration and rehabilitation in patients with sensory or motor dysfunction. Typical implantation surgeries are planned based on maps of brain activity generated from intact function. However, mapping brain activity for planning implantation surgeries is challenging in the target population due to abnormal residual function and, increasingly often, existing MRI-incompatible implanted hardware. Here, we present methods and results for mapping impaired somatosensory and motor function in an individual with paralysis and an existing brain–computer interface (BCI) device. Magnetoencephalography (MEG) was used to directly map the neural activity evoked during transcutaneous electrical stimulation and attempted movement of the impaired hand. Evoked fields were found to align with the expected anatomy and somatotopic organization. This approach may be valuable for guiding implants in other applications, such as cortical stimulation for pain and to improve implant targeting to help reduce the craniotomy size.https://www.frontiersin.org/articles/10.3389/fneur.2021.739693/fullmagnetoencephalographyparalysissensorimotor cortexbrain–computer interfaces foldsneuroprosthetics |
| spellingShingle | Stephen T. Foldes Santosh Chandrasekaran Joseph Camerone James Lowe Richard Ramdeo John Ebersole Chad E. Bouton Chad E. Bouton Case Study: Mapping Evoked Fields in Primary Motor and Sensory Areas via Magnetoencephalography in Tetraplegia Frontiers in Neurology magnetoencephalography paralysis sensorimotor cortex brain–computer interfaces folds neuroprosthetics |
| title | Case Study: Mapping Evoked Fields in Primary Motor and Sensory Areas via Magnetoencephalography in Tetraplegia |
| title_full | Case Study: Mapping Evoked Fields in Primary Motor and Sensory Areas via Magnetoencephalography in Tetraplegia |
| title_fullStr | Case Study: Mapping Evoked Fields in Primary Motor and Sensory Areas via Magnetoencephalography in Tetraplegia |
| title_full_unstemmed | Case Study: Mapping Evoked Fields in Primary Motor and Sensory Areas via Magnetoencephalography in Tetraplegia |
| title_short | Case Study: Mapping Evoked Fields in Primary Motor and Sensory Areas via Magnetoencephalography in Tetraplegia |
| title_sort | case study mapping evoked fields in primary motor and sensory areas via magnetoencephalography in tetraplegia |
| topic | magnetoencephalography paralysis sensorimotor cortex brain–computer interfaces folds neuroprosthetics |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.739693/full |
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