Optical coherence tomography angiography biomarkers of microvascular alterations in RVCL-S
BackgroundThe brain and retina share many neuronal and vasculature characteristics. We investigated the retinal microvasculature in patients with a monogenic vasculopathy using optical coherence tomography angiography (OCTA). OCT-A is a novel precise non-invasive imaging method that may provide biom...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.989536/full |
| _version_ | 1817997930407133184 |
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| author | Mays Al-Nofal Irene de Boer Seda Agirman Anne E. Wilms Amir H. Zamanipoor Najafabadi Gisela M. Terwindt Irene C. Notting |
| author_facet | Mays Al-Nofal Irene de Boer Seda Agirman Anne E. Wilms Amir H. Zamanipoor Najafabadi Gisela M. Terwindt Irene C. Notting |
| author_sort | Mays Al-Nofal |
| collection | DOAJ |
| description | BackgroundThe brain and retina share many neuronal and vasculature characteristics. We investigated the retinal microvasculature in patients with a monogenic vasculopathy using optical coherence tomography angiography (OCTA). OCT-A is a novel precise non-invasive imaging method that may provide biomarkers suitable for diagnosis and follow-up of small vessel diseases.MethodsIn this exploratory cross-sectional study, eleven RVCL-S patients and eleven age-matched healthy control participants were included. The size of the foveal avascular zone (FAZ) and the vascular density of the superficial capillary networks in the retina were measured by OCT-A.ResultsThe symptomatic and presymptomatic patients showed significantly lower vascular density values than controls in the foveal region [median (IQR) 18.2% (15.8–18.6) vs. 24.4% (21.5–26.8) (p < 0.001), 29.8% (29.6–30.8) vs. 33.2% (32.0–33.6) (p = 0.002), respectively]. The FAZ was significantly larger in the symptomatic RVCL-S patients than in the control group [13,416 square pixels [7,529–22,860] vs. 1,405 square pixels [1,344–2,470] (p < 0.001)]. No significant difference was identified in measurements of FAZ comparing presymptomatic and controls.ConclusionOur findings with OCT-A demonstrated that RVCL-S causes an increase in the size of the FAZ in symptomatic RVCL-S patients compared to healthy participants. Moreover, there is a decrease in vessel density in the superficial capillary networks in both symptomatic and presymptomatic patients. In the future, newly developed precise objective instruments such as OCT (-A) may provide important tools in determining disease activity for follow up of common small vessel diseases. |
| first_indexed | 2024-04-14T02:45:30Z |
| format | Article |
| id | doaj.art-4b1244df20cc4f7da225742c3ea25e74 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-14T02:45:30Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-4b1244df20cc4f7da225742c3ea25e742022-12-22T02:16:31ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-08-011310.3389/fneur.2022.989536989536Optical coherence tomography angiography biomarkers of microvascular alterations in RVCL-SMays Al-Nofal0Irene de Boer1Seda Agirman2Anne E. Wilms3Amir H. Zamanipoor Najafabadi4Gisela M. Terwindt5Irene C. Notting6Department of Ophthalmology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Neurology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Ophthalmology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Ophthalmology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Ophthalmology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Neurology, Leiden University Medical Center, Leiden, NetherlandsDepartment of Ophthalmology, Leiden University Medical Center, Leiden, NetherlandsBackgroundThe brain and retina share many neuronal and vasculature characteristics. We investigated the retinal microvasculature in patients with a monogenic vasculopathy using optical coherence tomography angiography (OCTA). OCT-A is a novel precise non-invasive imaging method that may provide biomarkers suitable for diagnosis and follow-up of small vessel diseases.MethodsIn this exploratory cross-sectional study, eleven RVCL-S patients and eleven age-matched healthy control participants were included. The size of the foveal avascular zone (FAZ) and the vascular density of the superficial capillary networks in the retina were measured by OCT-A.ResultsThe symptomatic and presymptomatic patients showed significantly lower vascular density values than controls in the foveal region [median (IQR) 18.2% (15.8–18.6) vs. 24.4% (21.5–26.8) (p < 0.001), 29.8% (29.6–30.8) vs. 33.2% (32.0–33.6) (p = 0.002), respectively]. The FAZ was significantly larger in the symptomatic RVCL-S patients than in the control group [13,416 square pixels [7,529–22,860] vs. 1,405 square pixels [1,344–2,470] (p < 0.001)]. No significant difference was identified in measurements of FAZ comparing presymptomatic and controls.ConclusionOur findings with OCT-A demonstrated that RVCL-S causes an increase in the size of the FAZ in symptomatic RVCL-S patients compared to healthy participants. Moreover, there is a decrease in vessel density in the superficial capillary networks in both symptomatic and presymptomatic patients. In the future, newly developed precise objective instruments such as OCT (-A) may provide important tools in determining disease activity for follow up of common small vessel diseases.https://www.frontiersin.org/articles/10.3389/fneur.2022.989536/fullRVCL-Sbiomarkerretinacerebral small vessel diseaseimagingoptical coherence tomography angiography |
| spellingShingle | Mays Al-Nofal Irene de Boer Seda Agirman Anne E. Wilms Amir H. Zamanipoor Najafabadi Gisela M. Terwindt Irene C. Notting Optical coherence tomography angiography biomarkers of microvascular alterations in RVCL-S Frontiers in Neurology RVCL-S biomarker retina cerebral small vessel disease imaging optical coherence tomography angiography |
| title | Optical coherence tomography angiography biomarkers of microvascular alterations in RVCL-S |
| title_full | Optical coherence tomography angiography biomarkers of microvascular alterations in RVCL-S |
| title_fullStr | Optical coherence tomography angiography biomarkers of microvascular alterations in RVCL-S |
| title_full_unstemmed | Optical coherence tomography angiography biomarkers of microvascular alterations in RVCL-S |
| title_short | Optical coherence tomography angiography biomarkers of microvascular alterations in RVCL-S |
| title_sort | optical coherence tomography angiography biomarkers of microvascular alterations in rvcl s |
| topic | RVCL-S biomarker retina cerebral small vessel disease imaging optical coherence tomography angiography |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.989536/full |
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