A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain

A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain

Glycoprotein US9 of human cytomegalovirus downregulates the activating immune ligand MICA*008 to avoid NK cell activation. Here, Seidel et al. show that the signal peptide of US9 is cleaved unusually slowly, causing MICA*008 to be retained in the endoplasmic reticulum (ER) and degraded via the ER qu...

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Xehetasun bibliografikoak
Egile Nagusiak: Einat Seidel, Liat Dassa, Shira Kahlon, Boaz Tirosh, Anne Halenius, Tal Seidel Malkinson, Ofer Mandelboim
Formatua: Artikulua
Hizkuntza:English
Argitaratua: Nature Portfolio 2021-04-01
Saila:Nature Communications
Sarrera elektronikoa:https://doi.org/10.1038/s41467-021-21983-x

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