The deubiquitinating enzyme USP4 regulates BRCA1 stability and function

The deubiquitinating enzyme USP4 regulates BRCA1 stability and function

Abstract BRCA1 plays a suppressive role in breast tumorigenesis. Ubiquitin-dependent degradation is a common mechanism that regulates BRCA1 protein stability, and several ubiquitin ligases involved have been identified. However, the deubiquitinating enzyme for BRCA1 remains less defined. Here, we re...

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Bibliographic Details
Main Authors: Xueyuan Guo, Yanfang Ma, Ting Zhang, Runyu Liu, Fen Chang, Xingyue Yan, Tianyun Yu, Pengfei Wu, Qin Li, Luzheng Xu, Junyi Duan, Li Li, Yanrong Su, Genze Shao
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-024-00641-7

Internet

https://doi.org/10.1038/s41523-024-00641-7

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