Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin
Despite the promising biological and antioxidant properties of curcumin, its medical applications are limited due to poor solubility in water and low bioavailability. Polymeric nanoparticles (NPs) adapted to oral delivery may overcome these drawbacks. Properties such as particle size, zeta potential...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-03-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-3921/7/4/46 |
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| author | Anita Umerska Caroline Gaucher Felipe Oyarzun-Ampuero Isabelle Fries-Raeth Florence Colin María Gabriela Villamizar-Sarmiento Philippe Maincent Anne Sapin-Minet |
| author_facet | Anita Umerska Caroline Gaucher Felipe Oyarzun-Ampuero Isabelle Fries-Raeth Florence Colin María Gabriela Villamizar-Sarmiento Philippe Maincent Anne Sapin-Minet |
| author_sort | Anita Umerska |
| collection | DOAJ |
| description | Despite the promising biological and antioxidant properties of curcumin, its medical applications are limited due to poor solubility in water and low bioavailability. Polymeric nanoparticles (NPs) adapted to oral delivery may overcome these drawbacks. Properties such as particle size, zeta potential, morphology and encapsulation efficiency were assessed. Then, the possibility of storing these NPs in a solid-state form obtained by freeze-drying, in vitro curcumin dissolution and cytocompatibility towards intestinal cells were evaluated. Curcumin-loaded Eudragit® RLPO (ERL) NPs showed smaller particle diameters (245 ± 2 nm) and better redispersibility after freeze-drying than either poly(lactic-co-glycolic acid) (PLGA) or polycaprolactone (PCL) NPs. The former NPs showed lower curcumin encapsulation efficiency (62%) than either PLGA or PCL NPs (90% and 99%, respectively). Nevertheless, ERL NPs showed rapid curcumin release with 91 ± 5% released over 1 h. The three curcumin-loaded NPs proposed in this work were also compatible with intestinal cells. Overall, ERL NPs are the most promising vehicles for increasing the oral bioavailability of curcumin. |
| first_indexed | 2024-03-12T09:53:16Z |
| format | Article |
| id | doaj.art-4b143848f618403eb495564ea4e39440 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T09:53:16Z |
| publishDate | 2018-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-4b143848f618403eb495564ea4e394402023-09-02T12:23:32ZengMDPI AGAntioxidants2076-39212018-03-01744610.3390/antiox7040046antiox7040046Polymeric Nanoparticles for Increasing Oral Bioavailability of CurcuminAnita Umerska0Caroline Gaucher1Felipe Oyarzun-Ampuero2Isabelle Fries-Raeth3Florence Colin4María Gabriela Villamizar-Sarmiento5Philippe Maincent6Anne Sapin-Minet7Université de Lorraine, CITHEFOR, F-54000 Nancy, FranceUniversité de Lorraine, CITHEFOR, F-54000 Nancy, FranceDepartamento de Ciencias y Tecnología Farmacéuticas, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, 758-0150 Santiago, ChileUniversité de Lorraine, CITHEFOR, F-54000 Nancy, FranceUniversité de Lorraine, CITHEFOR, F-54000 Nancy, FranceDepartamento de Ciencias y Tecnología Farmacéuticas, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, 758-0150 Santiago, ChileUniversité de Lorraine, CITHEFOR, F-54000 Nancy, FranceUniversité de Lorraine, CITHEFOR, F-54000 Nancy, FranceDespite the promising biological and antioxidant properties of curcumin, its medical applications are limited due to poor solubility in water and low bioavailability. Polymeric nanoparticles (NPs) adapted to oral delivery may overcome these drawbacks. Properties such as particle size, zeta potential, morphology and encapsulation efficiency were assessed. Then, the possibility of storing these NPs in a solid-state form obtained by freeze-drying, in vitro curcumin dissolution and cytocompatibility towards intestinal cells were evaluated. Curcumin-loaded Eudragit® RLPO (ERL) NPs showed smaller particle diameters (245 ± 2 nm) and better redispersibility after freeze-drying than either poly(lactic-co-glycolic acid) (PLGA) or polycaprolactone (PCL) NPs. The former NPs showed lower curcumin encapsulation efficiency (62%) than either PLGA or PCL NPs (90% and 99%, respectively). Nevertheless, ERL NPs showed rapid curcumin release with 91 ± 5% released over 1 h. The three curcumin-loaded NPs proposed in this work were also compatible with intestinal cells. Overall, ERL NPs are the most promising vehicles for increasing the oral bioavailability of curcumin.http://www.mdpi.com/2076-3921/7/4/46curcuminnanoparticlesPLGAPCLEudragitcytocompatibilityintestinal cellssingle emulsion-solvent evaporation method |
| spellingShingle | Anita Umerska Caroline Gaucher Felipe Oyarzun-Ampuero Isabelle Fries-Raeth Florence Colin María Gabriela Villamizar-Sarmiento Philippe Maincent Anne Sapin-Minet Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin Antioxidants curcumin nanoparticles PLGA PCL Eudragit cytocompatibility intestinal cells single emulsion-solvent evaporation method |
| title | Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin |
| title_full | Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin |
| title_fullStr | Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin |
| title_full_unstemmed | Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin |
| title_short | Polymeric Nanoparticles for Increasing Oral Bioavailability of Curcumin |
| title_sort | polymeric nanoparticles for increasing oral bioavailability of curcumin |
| topic | curcumin nanoparticles PLGA PCL Eudragit cytocompatibility intestinal cells single emulsion-solvent evaporation method |
| url | http://www.mdpi.com/2076-3921/7/4/46 |
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