Glomerular solidification is associated with nephritis-related clinical parameters in IgA nephropathy
Background: Two types of global glomerulosclerosis, glomerular obsolescence and solidification, have been identified. A clinicopathological correlation between these glomerular changes and hypertensive nephrosclerosis has been reported; however, clinicopathological correlations with other kidney dis...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0886022X.2019.1665545 |
| _version_ | 1819101814592634880 |
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| author | Tsutomu Inoue Yankun Luo Takeru Seto Hiromichi Suzuki Hirokazu Okada |
| author_facet | Tsutomu Inoue Yankun Luo Takeru Seto Hiromichi Suzuki Hirokazu Okada |
| author_sort | Tsutomu Inoue |
| collection | DOAJ |
| description | Background: Two types of global glomerulosclerosis, glomerular obsolescence and solidification, have been identified. A clinicopathological correlation between these glomerular changes and hypertensive nephrosclerosis has been reported; however, clinicopathological correlations with other kidney diseases are unknown. The aim of this study was to evaluate the correlation between the two glomerulosclerosis types and the clinical IgA nephropathy presentation. Methods: A single center, cross-sectional study of patients with IgA nephropathy was performed. Correlations between glomerulosclerosis and body mass index, mean blood pressure, creatinine-based estimated glomerular filtration rate (eGFR), total cholesterol, urinary protein corrected by urinary creatinine, and anti-hypertensive agent use were investigated using univariate and multivariate analyses. Results: Overall, 116 patients were enrolled (male/female, 59/57; mean age, 40.5 ± 15.0 years). Separate analyses were performed for solidification and obsolescence glomerulosclerosis. Univariate analysis demonstrated a significant correlation between the percentage of solidification glomerulosclerosis and patient age, mean blood pressure, eGFR, and use of antihypertensive drugs. Multivariate analysis showed that only eGFR and use of antihypertensive drugs maintained their independent predictive value. The amount of urinary protein emerged as a significant factor based on the multivariate analysis. However, although the univariate analysis demonstrated a statistically significant correlation between the percentage of obsolescence and eGFR for obsolescence glomerulosclerosis, a multivariate analysis indicated that none of the factors maintained their independent predictive value. Conclusions: The incidence of solidification was better correlated with some nephritis-related clinical parameters compared with the incidence of obsolescence. The emergence of solidification may influence the clinical activities that are associated with IgA nephropathy. |
| first_indexed | 2024-12-22T01:24:39Z |
| format | Article |
| id | doaj.art-4b15924b6b664f1b9b7f7e3262000907 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-22T01:24:39Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-4b15924b6b664f1b9b7f7e32620009072022-12-21T18:43:38ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492019-01-0141189389810.1080/0886022X.2019.16655451665545Glomerular solidification is associated with nephritis-related clinical parameters in IgA nephropathyTsutomu Inoue0Yankun Luo1Takeru Seto2Hiromichi Suzuki3Hirokazu Okada4Saitama Medical UniversitySaitama Medical UniversitySaitama Medical UniversitySaitama Medical UniversitySaitama Medical UniversityBackground: Two types of global glomerulosclerosis, glomerular obsolescence and solidification, have been identified. A clinicopathological correlation between these glomerular changes and hypertensive nephrosclerosis has been reported; however, clinicopathological correlations with other kidney diseases are unknown. The aim of this study was to evaluate the correlation between the two glomerulosclerosis types and the clinical IgA nephropathy presentation. Methods: A single center, cross-sectional study of patients with IgA nephropathy was performed. Correlations between glomerulosclerosis and body mass index, mean blood pressure, creatinine-based estimated glomerular filtration rate (eGFR), total cholesterol, urinary protein corrected by urinary creatinine, and anti-hypertensive agent use were investigated using univariate and multivariate analyses. Results: Overall, 116 patients were enrolled (male/female, 59/57; mean age, 40.5 ± 15.0 years). Separate analyses were performed for solidification and obsolescence glomerulosclerosis. Univariate analysis demonstrated a significant correlation between the percentage of solidification glomerulosclerosis and patient age, mean blood pressure, eGFR, and use of antihypertensive drugs. Multivariate analysis showed that only eGFR and use of antihypertensive drugs maintained their independent predictive value. The amount of urinary protein emerged as a significant factor based on the multivariate analysis. However, although the univariate analysis demonstrated a statistically significant correlation between the percentage of obsolescence and eGFR for obsolescence glomerulosclerosis, a multivariate analysis indicated that none of the factors maintained their independent predictive value. Conclusions: The incidence of solidification was better correlated with some nephritis-related clinical parameters compared with the incidence of obsolescence. The emergence of solidification may influence the clinical activities that are associated with IgA nephropathy.http://dx.doi.org/10.1080/0886022X.2019.1665545glomerulosclerosisiga nephropathyobsolescencesolidification |
| spellingShingle | Tsutomu Inoue Yankun Luo Takeru Seto Hiromichi Suzuki Hirokazu Okada Glomerular solidification is associated with nephritis-related clinical parameters in IgA nephropathy Renal Failure glomerulosclerosis iga nephropathy obsolescence solidification |
| title | Glomerular solidification is associated with nephritis-related clinical parameters in IgA nephropathy |
| title_full | Glomerular solidification is associated with nephritis-related clinical parameters in IgA nephropathy |
| title_fullStr | Glomerular solidification is associated with nephritis-related clinical parameters in IgA nephropathy |
| title_full_unstemmed | Glomerular solidification is associated with nephritis-related clinical parameters in IgA nephropathy |
| title_short | Glomerular solidification is associated with nephritis-related clinical parameters in IgA nephropathy |
| title_sort | glomerular solidification is associated with nephritis related clinical parameters in iga nephropathy |
| topic | glomerulosclerosis iga nephropathy obsolescence solidification |
| url | http://dx.doi.org/10.1080/0886022X.2019.1665545 |
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