The Fibrotic Effects of LINC00663 in Human Hepatic Stellate LX-2 Cells and in Bile Duct-Ligated Cholestasis Mice Are Mediated through the Splicing Factor 2-Fibronectin

The Fibrotic Effects of LINC00663 in Human Hepatic Stellate LX-2 Cells and in Bile Duct-Ligated Cholestasis Mice Are Mediated through the Splicing Factor 2-Fibronectin

Hepatic fibrosis can develop into cirrhosis or even cancer without active therapy at an early stage. Long non-coding RNAs (lncRNAs) have been shown to be involved in the regulation of a wide variety of important biological processes. However, lncRNA mechanism(s) involved in cholestatic liver fibrosi...

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Bibliographic Details
Main Authors: Yang Chu, Linan Bao, Yun Teng, Bo Yuan, Lijie Ma, Ying Liu, Hui Kang
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cells
Subjects:
LINC00663
splicing factor 2
fibronectin
alternative splicing
hsa-miR-3916
Online Access:https://www.mdpi.com/2073-4409/12/2/215

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