Potential Mechanisms Underlying Inflammation-Enhanced Aminoglycoside-Induced Cochleotoxicity

Potential Mechanisms Underlying Inflammation-Enhanced Aminoglycoside-Induced Cochleotoxicity

Aminoglycoside antibiotics remain widely used for urgent clinical treatment of life-threatening infections, despite the well-recognized risk of permanent hearing loss, i.e., cochleotoxicity. Recent studies show that aminoglycoside-induced cochleotoxicity is exacerbated by bacteriogenic-induced infla...

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Bibliographic Details
Main Authors: Meiyan Jiang, Farshid Taghizadeh, Peter S. Steyger
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
aminoglycosides
gentamicin
ototoxicity
sepsis
infection
bacteriogenic
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00362/full

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