Association between endothelin-1, nitric oxide, and Gensini score in chronic coronary syndrome
Abstract Background Chronic coronary syndrome (CCS) is a major public health burden; its pathogenesis involves atherosclerosis and endothelial dysfunction. Endothelin-1 (ET-1) and nitric oxide (NO) are vasoactive substances synthesized by endothelial cells that play a crucial role in CCS development...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03625-w |
| _version_ | 1827590762459561984 |
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| author | Yujin Wang Yuqin Wang Tiaoxia Liu Yifan Qin Futian Tang Xiaowei Zhang Yongnan Li |
| author_facet | Yujin Wang Yuqin Wang Tiaoxia Liu Yifan Qin Futian Tang Xiaowei Zhang Yongnan Li |
| author_sort | Yujin Wang |
| collection | DOAJ |
| description | Abstract Background Chronic coronary syndrome (CCS) is a major public health burden; its pathogenesis involves atherosclerosis and endothelial dysfunction. Endothelin-1 (ET-1) and nitric oxide (NO) are vasoactive substances synthesized by endothelial cells that play a crucial role in CCS development. The Gensini score (GS) is used for evaluating CCS severity based on lumen segment changes, stenosis degree, and coronary stenosis site. Methods This prospective study included 71 patients with CCS; we evaluated the relationships between GS and ET-1 and NO serum levels were evaluated in these patients. The GS was calculated for all patients. Serum ET-1 & NO levels among other laboratory parameters were measured. Results The high GS group had higher ET-1 and relatively NO expressions in the than the low GS group. GS was positively correlated with ET-1 and negatively correlated with NO, T4, and TSH levels. The results of the multiple linear regression analysis showed that ET-1 had the most significant effect on GS. Conclusions We found a strong association between ET-1, NO, and CCS severity. A combination of ET-1, NO, and GS is an essential predictor of CCS disease severity. |
| first_indexed | 2024-03-09T01:21:21Z |
| format | Article |
| id | doaj.art-4b18cd27d8d34aadac1f28dc0a6d71d5 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-09T01:21:21Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-4b18cd27d8d34aadac1f28dc0a6d71d52023-12-10T12:06:25ZengBMCBMC Cardiovascular Disorders1471-22612023-12-012311610.1186/s12872-023-03625-wAssociation between endothelin-1, nitric oxide, and Gensini score in chronic coronary syndromeYujin Wang0Yuqin Wang1Tiaoxia Liu2Yifan Qin3Futian Tang4Xiaowei Zhang5Yongnan Li6Lanzhou University Second College of Clinical MedicineLanzhou University Second College of Clinical MedicineDepartment of Cardiology, Lanzhou University Second HospitalDepartment of Cardiology, Lanzhou University Second HospitalLanzhou University Second College of Clinical MedicineLanzhou University Second College of Clinical MedicineLanzhou University Second College of Clinical MedicineAbstract Background Chronic coronary syndrome (CCS) is a major public health burden; its pathogenesis involves atherosclerosis and endothelial dysfunction. Endothelin-1 (ET-1) and nitric oxide (NO) are vasoactive substances synthesized by endothelial cells that play a crucial role in CCS development. The Gensini score (GS) is used for evaluating CCS severity based on lumen segment changes, stenosis degree, and coronary stenosis site. Methods This prospective study included 71 patients with CCS; we evaluated the relationships between GS and ET-1 and NO serum levels were evaluated in these patients. The GS was calculated for all patients. Serum ET-1 & NO levels among other laboratory parameters were measured. Results The high GS group had higher ET-1 and relatively NO expressions in the than the low GS group. GS was positively correlated with ET-1 and negatively correlated with NO, T4, and TSH levels. The results of the multiple linear regression analysis showed that ET-1 had the most significant effect on GS. Conclusions We found a strong association between ET-1, NO, and CCS severity. A combination of ET-1, NO, and GS is an essential predictor of CCS disease severity.https://doi.org/10.1186/s12872-023-03625-wGensini scoreEndothelin-1Nitric oxideChronic coronary syndrome |
| spellingShingle | Yujin Wang Yuqin Wang Tiaoxia Liu Yifan Qin Futian Tang Xiaowei Zhang Yongnan Li Association between endothelin-1, nitric oxide, and Gensini score in chronic coronary syndrome BMC Cardiovascular Disorders Gensini score Endothelin-1 Nitric oxide Chronic coronary syndrome |
| title | Association between endothelin-1, nitric oxide, and Gensini score in chronic coronary syndrome |
| title_full | Association between endothelin-1, nitric oxide, and Gensini score in chronic coronary syndrome |
| title_fullStr | Association between endothelin-1, nitric oxide, and Gensini score in chronic coronary syndrome |
| title_full_unstemmed | Association between endothelin-1, nitric oxide, and Gensini score in chronic coronary syndrome |
| title_short | Association between endothelin-1, nitric oxide, and Gensini score in chronic coronary syndrome |
| title_sort | association between endothelin 1 nitric oxide and gensini score in chronic coronary syndrome |
| topic | Gensini score Endothelin-1 Nitric oxide Chronic coronary syndrome |
| url | https://doi.org/10.1186/s12872-023-03625-w |
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