Human Microphysiological Models of Intestinal Tissue and Gut Microbiome
The gastrointestinal (GI) tract is a complex system responsible for nutrient absorption, digestion, secretion, and elimination of waste products that also hosts immune surveillance, the intestinal microbiome, and interfaces with the nervous system. Traditional in vitro systems cannot harness the arc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fbioe.2020.00725/full |
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| author | Steven N. Steinway Jad Saleh Bon-Kyoung Koo Delphine Delacour Deok-Ho Kim Deok-Ho Kim |
| author_facet | Steven N. Steinway Jad Saleh Bon-Kyoung Koo Delphine Delacour Deok-Ho Kim Deok-Ho Kim |
| author_sort | Steven N. Steinway |
| collection | DOAJ |
| description | The gastrointestinal (GI) tract is a complex system responsible for nutrient absorption, digestion, secretion, and elimination of waste products that also hosts immune surveillance, the intestinal microbiome, and interfaces with the nervous system. Traditional in vitro systems cannot harness the architectural and functional complexity of the GI tract. Recent advances in organoid engineering, microfluidic organs-on-a-chip technology, and microfabrication allows us to create better in vitro models of human organs/tissues. These micro-physiological systems could integrate the numerous cell types involved in GI development and physiology, including intestinal epithelium, endothelium (vascular), nerve cells, immune cells, and their interplay/cooperativity with the microbiome. In this review, we report recent progress in developing micro-physiological models of the GI systems. We also discuss how these models could be used to study normal intestinal physiology such as nutrient absorption, digestion, and secretion as well as GI infection, inflammation, cancer, and metabolism. |
| first_indexed | 2024-12-13T12:34:59Z |
| format | Article |
| id | doaj.art-4b197823a33045c8b92bc53e6338d976 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-13T12:34:59Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-4b197823a33045c8b92bc53e6338d9762022-12-21T23:45:53ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-07-01810.3389/fbioe.2020.00725537914Human Microphysiological Models of Intestinal Tissue and Gut MicrobiomeSteven N. Steinway0Jad Saleh1Bon-Kyoung Koo2Delphine Delacour3Deok-Ho Kim4Deok-Ho Kim5Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesCell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR 7592, Paris Diderot University, Paris, FranceInstitute of Molecular Biotechnology, Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC), Vienna, AustriaCell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR 7592, Paris Diderot University, Paris, FranceDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesThe gastrointestinal (GI) tract is a complex system responsible for nutrient absorption, digestion, secretion, and elimination of waste products that also hosts immune surveillance, the intestinal microbiome, and interfaces with the nervous system. Traditional in vitro systems cannot harness the architectural and functional complexity of the GI tract. Recent advances in organoid engineering, microfluidic organs-on-a-chip technology, and microfabrication allows us to create better in vitro models of human organs/tissues. These micro-physiological systems could integrate the numerous cell types involved in GI development and physiology, including intestinal epithelium, endothelium (vascular), nerve cells, immune cells, and their interplay/cooperativity with the microbiome. In this review, we report recent progress in developing micro-physiological models of the GI systems. We also discuss how these models could be used to study normal intestinal physiology such as nutrient absorption, digestion, and secretion as well as GI infection, inflammation, cancer, and metabolism.https://www.frontiersin.org/article/10.3389/fbioe.2020.00725/fullmicrophysiological modelgut-on-a-chiporgan chipmicrobiomeintestinal tissueorganoid |
| spellingShingle | Steven N. Steinway Jad Saleh Bon-Kyoung Koo Delphine Delacour Deok-Ho Kim Deok-Ho Kim Human Microphysiological Models of Intestinal Tissue and Gut Microbiome Frontiers in Bioengineering and Biotechnology microphysiological model gut-on-a-chip organ chip microbiome intestinal tissue organoid |
| title | Human Microphysiological Models of Intestinal Tissue and Gut Microbiome |
| title_full | Human Microphysiological Models of Intestinal Tissue and Gut Microbiome |
| title_fullStr | Human Microphysiological Models of Intestinal Tissue and Gut Microbiome |
| title_full_unstemmed | Human Microphysiological Models of Intestinal Tissue and Gut Microbiome |
| title_short | Human Microphysiological Models of Intestinal Tissue and Gut Microbiome |
| title_sort | human microphysiological models of intestinal tissue and gut microbiome |
| topic | microphysiological model gut-on-a-chip organ chip microbiome intestinal tissue organoid |
| url | https://www.frontiersin.org/article/10.3389/fbioe.2020.00725/full |
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