Newer antidiabetic drugs and calorie restriction mimicry
De-acceleration of aging and delayed development of age-related morbidity accompanies the restriction of calories (without malnutrition) in laboratory mice, nematodes, yeast, fish, and dogs. Recent results from long-term longitudinal studies conducted on primates have suggested longevity benefits of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=1;spage=142;epage=146;aulast=Kalra |
| _version_ | 1818934051973627904 |
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| author | Sanjay Kalra Jubbin Jagan Jacob Yashdeep Gupta |
| author_facet | Sanjay Kalra Jubbin Jagan Jacob Yashdeep Gupta |
| author_sort | Sanjay Kalra |
| collection | DOAJ |
| description | De-acceleration of aging and delayed development of age-related morbidity accompanies the restriction of calories (without malnutrition) in laboratory mice, nematodes, yeast, fish, and dogs. Recent results from long-term longitudinal studies conducted on primates have suggested longevity benefits of a 30% restriction of calories in rhesus monkeys as well. Among calorie restricted rhesus monkeys one of the mechanisms for the improvement in lifespan was the reduction in the development of glucose intolerance and cardiovascular disease. Although there are no comparable human studies, it is likely that metabolic and longevity benefits will accompany a reduction in calories in humans as well. However, considering the difficulties in getting healthy adults to limit food intake science has focused on understanding the biochemical processes that accompany calorie restriction (CR) to formulate drugs that would mimic the effects of CR without the need to actually restrict calories. Drugs in this emerging therapeutic field are called CR mimetics. Some of the currently used anti-diabetic agents may have some CR mimetic like effects. This review focuses on the CR mimetic properties of the currently available anti-diabetic agents. |
| first_indexed | 2024-12-20T04:58:08Z |
| format | Article |
| id | doaj.art-4b1a7786f2b7462a9280648256987ead |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-12-20T04:58:08Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-4b1a7786f2b7462a9280648256987ead2022-12-21T19:52:39ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002016-01-0120114214610.4103/2230-8210.172242Newer antidiabetic drugs and calorie restriction mimicrySanjay KalraJubbin Jagan JacobYashdeep GuptaDe-acceleration of aging and delayed development of age-related morbidity accompanies the restriction of calories (without malnutrition) in laboratory mice, nematodes, yeast, fish, and dogs. Recent results from long-term longitudinal studies conducted on primates have suggested longevity benefits of a 30% restriction of calories in rhesus monkeys as well. Among calorie restricted rhesus monkeys one of the mechanisms for the improvement in lifespan was the reduction in the development of glucose intolerance and cardiovascular disease. Although there are no comparable human studies, it is likely that metabolic and longevity benefits will accompany a reduction in calories in humans as well. However, considering the difficulties in getting healthy adults to limit food intake science has focused on understanding the biochemical processes that accompany calorie restriction (CR) to formulate drugs that would mimic the effects of CR without the need to actually restrict calories. Drugs in this emerging therapeutic field are called CR mimetics. Some of the currently used anti-diabetic agents may have some CR mimetic like effects. This review focuses on the CR mimetic properties of the currently available anti-diabetic agents.http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=1;spage=142;epage=146;aulast=KalraAlpha-glucosidase inhibitorscanagliflozindapagliflozindipeptidyl peptidase-4 inhibitorsexenatideexenatide QWglucagon like peptide-1 receptor agonists inhibitorsliraglutidemetforminpioglitazonesodium glucose co-transporter 2 |
| spellingShingle | Sanjay Kalra Jubbin Jagan Jacob Yashdeep Gupta Newer antidiabetic drugs and calorie restriction mimicry Indian Journal of Endocrinology and Metabolism Alpha-glucosidase inhibitors canagliflozin dapagliflozin dipeptidyl peptidase-4 inhibitors exenatide exenatide QW glucagon like peptide-1 receptor agonists inhibitors liraglutide metformin pioglitazone sodium glucose co-transporter 2 |
| title | Newer antidiabetic drugs and calorie restriction mimicry |
| title_full | Newer antidiabetic drugs and calorie restriction mimicry |
| title_fullStr | Newer antidiabetic drugs and calorie restriction mimicry |
| title_full_unstemmed | Newer antidiabetic drugs and calorie restriction mimicry |
| title_short | Newer antidiabetic drugs and calorie restriction mimicry |
| title_sort | newer antidiabetic drugs and calorie restriction mimicry |
| topic | Alpha-glucosidase inhibitors canagliflozin dapagliflozin dipeptidyl peptidase-4 inhibitors exenatide exenatide QW glucagon like peptide-1 receptor agonists inhibitors liraglutide metformin pioglitazone sodium glucose co-transporter 2 |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=1;spage=142;epage=146;aulast=Kalra |
| work_keys_str_mv | AT sanjaykalra newerantidiabeticdrugsandcalorierestrictionmimicry AT jubbinjaganjacob newerantidiabeticdrugsandcalorierestrictionmimicry AT yashdeepgupta newerantidiabeticdrugsandcalorierestrictionmimicry |