Surface configuration of microarc oxidized Ti with regionally loaded chitosan hydrogel containing ciprofloxacin for improving biological performance
The bacterial colonization and poor osseointegration of Ti implants significantly compromise their applications in load-bearing bone repair and replacement. To endorse the Ti with both excellent bioactivity and antibacterial ability, we developed a microarc oxidation coating that was modified unifor...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422001788 |
| _version_ | 1798030718292459520 |
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| author | Rui Zhou Ying Zhou Jiahui Cheng Jianyun Cao Ming Li Hailing Yu Daqing Wei Baoqiang Li Yaming Wang Yu Zhou |
| author_facet | Rui Zhou Ying Zhou Jiahui Cheng Jianyun Cao Ming Li Hailing Yu Daqing Wei Baoqiang Li Yaming Wang Yu Zhou |
| author_sort | Rui Zhou |
| collection | DOAJ |
| description | The bacterial colonization and poor osseointegration of Ti implants significantly compromise their applications in load-bearing bone repair and replacement. To endorse the Ti with both excellent bioactivity and antibacterial ability, we developed a microarc oxidation coating that was modified uniformly by hydroxyapatite (HA) nanodots arrays and loaded regionally with chitosan hydrogel containing ciprofloxacin. The bonding between the HA nanodots covered coating and the chitosan hydrogel is further enhanced via silanization and chemical grafting of glutaraldehyde. Benefiting from the regionally loaded structure of the chitosan hydrogel, the chitosan hydrogel unloaded area can promote the cell adhesion and proliferation with excellent bioactivity, though relatively low OD value of cck8 has been observed at the beginning of the cell culturing. Whereas, the OD value of cck8 rises with the prolongation of the cell culturing time due to the degradation of the regionally loaded chitosan hydrogel. With the help of the laden ciprofloxacin in chitosan hydrogels, the sample effectively sterilizes the bacterial with a bacteriostatic ring. Therefore, regional loading of chitosan hydrogel containing ciprofloxacin on the modified microarc oxidation coating is a good approach to endorse Ti with both excellent bioactivity and antibacterial ability. |
| first_indexed | 2024-04-11T19:45:55Z |
| format | Article |
| id | doaj.art-4b1c75eaa8ea40b6b74b0030483b1878 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-11T19:45:55Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-4b1c75eaa8ea40b6b74b0030483b18782022-12-22T04:06:29ZengElsevierMaterials Today Bio2590-00642022-12-0116100380Surface configuration of microarc oxidized Ti with regionally loaded chitosan hydrogel containing ciprofloxacin for improving biological performanceRui Zhou0Ying Zhou1Jiahui Cheng2Jianyun Cao3Ming Li4Hailing Yu5Daqing Wei6Baoqiang Li7Yaming Wang8Yu Zhou9State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, PR China; Corresponding author.State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, PR ChinaThe Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an, 710004, PR ChinaKey Laboratory of LCR Materials and Devices of Yunnan Province, School of Materials and Energy, Yunnan University, Kunming, 650500, PR ChinaHonghui Hospital, Xi'an Jiaotong University, Xi'an, 710054, PR China; Corresponding author.The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong Province, 519000, PR ChinaDepartment of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150080, PR ChinaDepartment of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150080, PR ChinaDepartment of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150080, PR ChinaDepartment of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150080, PR ChinaThe bacterial colonization and poor osseointegration of Ti implants significantly compromise their applications in load-bearing bone repair and replacement. To endorse the Ti with both excellent bioactivity and antibacterial ability, we developed a microarc oxidation coating that was modified uniformly by hydroxyapatite (HA) nanodots arrays and loaded regionally with chitosan hydrogel containing ciprofloxacin. The bonding between the HA nanodots covered coating and the chitosan hydrogel is further enhanced via silanization and chemical grafting of glutaraldehyde. Benefiting from the regionally loaded structure of the chitosan hydrogel, the chitosan hydrogel unloaded area can promote the cell adhesion and proliferation with excellent bioactivity, though relatively low OD value of cck8 has been observed at the beginning of the cell culturing. Whereas, the OD value of cck8 rises with the prolongation of the cell culturing time due to the degradation of the regionally loaded chitosan hydrogel. With the help of the laden ciprofloxacin in chitosan hydrogels, the sample effectively sterilizes the bacterial with a bacteriostatic ring. Therefore, regional loading of chitosan hydrogel containing ciprofloxacin on the modified microarc oxidation coating is a good approach to endorse Ti with both excellent bioactivity and antibacterial ability.http://www.sciencedirect.com/science/article/pii/S2590006422001788Microarc oxidation coatingCchitosan hydrogelCciprofloxacinRregionally loaded structureBbioactivityAantibacterial ability |
| spellingShingle | Rui Zhou Ying Zhou Jiahui Cheng Jianyun Cao Ming Li Hailing Yu Daqing Wei Baoqiang Li Yaming Wang Yu Zhou Surface configuration of microarc oxidized Ti with regionally loaded chitosan hydrogel containing ciprofloxacin for improving biological performance Materials Today Bio Microarc oxidation coating Cchitosan hydrogel Cciprofloxacin Rregionally loaded structure Bbioactivity Aantibacterial ability |
| title | Surface configuration of microarc oxidized Ti with regionally loaded chitosan hydrogel containing ciprofloxacin for improving biological performance |
| title_full | Surface configuration of microarc oxidized Ti with regionally loaded chitosan hydrogel containing ciprofloxacin for improving biological performance |
| title_fullStr | Surface configuration of microarc oxidized Ti with regionally loaded chitosan hydrogel containing ciprofloxacin for improving biological performance |
| title_full_unstemmed | Surface configuration of microarc oxidized Ti with regionally loaded chitosan hydrogel containing ciprofloxacin for improving biological performance |
| title_short | Surface configuration of microarc oxidized Ti with regionally loaded chitosan hydrogel containing ciprofloxacin for improving biological performance |
| title_sort | surface configuration of microarc oxidized ti with regionally loaded chitosan hydrogel containing ciprofloxacin for improving biological performance |
| topic | Microarc oxidation coating Cchitosan hydrogel Cciprofloxacin Rregionally loaded structure Bbioactivity Aantibacterial ability |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422001788 |
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