Perspectives of general practitioners and memory clinic patients on ageing and cognitive decline to inform the design of a decentralised antihypertensive dementia prevention trial
Background: The global burden dementia is growing each year. Clinical trials investigating approaches to preventing dementia have been occurring for decades, but they are particularly challenging including the requirement to include large numbers of healthy ‘at-risk’ people who need to be followed u...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Cerebral Circulation - Cognition and Behavior |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666245024000163 |
| _version_ | 1797299680192757760 |
|---|---|
| author | Alexandra Hurden Isabella Cotter Loren Mowszowski Sharon Naismith Craig S. Anderson |
| author_facet | Alexandra Hurden Isabella Cotter Loren Mowszowski Sharon Naismith Craig S. Anderson |
| author_sort | Alexandra Hurden |
| collection | DOAJ |
| description | Background: The global burden dementia is growing each year. Clinical trials investigating approaches to preventing dementia have been occurring for decades, but they are particularly challenging including the requirement to include large numbers of healthy ‘at-risk’ people who need to be followed up for a long period of time. Community and consumer involvement in trial design helps to ensure that the methods are acceptable to the involved stakeholders, the design and operation of clinical trials are suitable and applicable to the target population, and that key areas of concern are identified and addressed at an early stage. Objectives: To gain insights from samples of memory clinic patients without dementia and general practitioners on the acceptability of, and attitudes towards, the proposed design of a decentralised antihypertensive dementia prevention trial. Topics addressed included the assessment of cognition, antihypertensive medication use, and motivation to participate in research. Methods: Two focus groups (total n = 7) with memory clinic patients and individual interviews with GPs (n = 5) were conducted. Transcripts were analysed using qualitative thematic framework analysis. Results: The proposed design was acceptable, with some possible barriers identified regarding computer use, GP time restraints, and concerns about medication interactions. Additional themes included the importance of communication and social connectedness in research participation and perceptions of ageing in medical settings. Future directions of research into larger studies and consumer-led research practices were discussed. Conclusion: The proposed trial design was agreed to be acceptable with some operational considerations, which were incorporated in the trial design. |
| first_indexed | 2024-03-07T22:53:11Z |
| format | Article |
| id | doaj.art-4b1dac6995af41cbaa9b125070210549 |
| institution | Directory Open Access Journal |
| issn | 2666-2450 |
| language | English |
| last_indexed | 2024-03-07T22:53:11Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cerebral Circulation - Cognition and Behavior |
| spelling | doaj.art-4b1dac6995af41cbaa9b1250702105492024-02-23T05:00:49ZengElsevierCerebral Circulation - Cognition and Behavior2666-24502024-01-016100215Perspectives of general practitioners and memory clinic patients on ageing and cognitive decline to inform the design of a decentralised antihypertensive dementia prevention trialAlexandra Hurden0Isabella Cotter1Loren Mowszowski2Sharon Naismith3Craig S. Anderson4The George Institute, Sydney, Australia; Faculty of Medicine, The University of New South Wales, AustraliaThe George Institute, Sydney, AustraliaBrain and Mind Centre, The University of Sydney, Sydney, Australia; Faculty of Science, School of Psychology, The University of Sydney, Sydney, AustraliaBrain and Mind Centre, The University of Sydney, Sydney, Australia; Faculty of Science, School of Psychology, The University of Sydney, Sydney, AustraliaThe George Institute, Sydney, Australia; Faculty of Medicine, The University of New South Wales, Australia; Corresponding author at: The George Institute, Sydney, AustraliaBackground: The global burden dementia is growing each year. Clinical trials investigating approaches to preventing dementia have been occurring for decades, but they are particularly challenging including the requirement to include large numbers of healthy ‘at-risk’ people who need to be followed up for a long period of time. Community and consumer involvement in trial design helps to ensure that the methods are acceptable to the involved stakeholders, the design and operation of clinical trials are suitable and applicable to the target population, and that key areas of concern are identified and addressed at an early stage. Objectives: To gain insights from samples of memory clinic patients without dementia and general practitioners on the acceptability of, and attitudes towards, the proposed design of a decentralised antihypertensive dementia prevention trial. Topics addressed included the assessment of cognition, antihypertensive medication use, and motivation to participate in research. Methods: Two focus groups (total n = 7) with memory clinic patients and individual interviews with GPs (n = 5) were conducted. Transcripts were analysed using qualitative thematic framework analysis. Results: The proposed design was acceptable, with some possible barriers identified regarding computer use, GP time restraints, and concerns about medication interactions. Additional themes included the importance of communication and social connectedness in research participation and perceptions of ageing in medical settings. Future directions of research into larger studies and consumer-led research practices were discussed. Conclusion: The proposed trial design was agreed to be acceptable with some operational considerations, which were incorporated in the trial design.http://www.sciencedirect.com/science/article/pii/S2666245024000163DementiaInterviewFocus groupDementia preventionBlood pressureTrial design |
| spellingShingle | Alexandra Hurden Isabella Cotter Loren Mowszowski Sharon Naismith Craig S. Anderson Perspectives of general practitioners and memory clinic patients on ageing and cognitive decline to inform the design of a decentralised antihypertensive dementia prevention trial Cerebral Circulation - Cognition and Behavior Dementia Interview Focus group Dementia prevention Blood pressure Trial design |
| title | Perspectives of general practitioners and memory clinic patients on ageing and cognitive decline to inform the design of a decentralised antihypertensive dementia prevention trial |
| title_full | Perspectives of general practitioners and memory clinic patients on ageing and cognitive decline to inform the design of a decentralised antihypertensive dementia prevention trial |
| title_fullStr | Perspectives of general practitioners and memory clinic patients on ageing and cognitive decline to inform the design of a decentralised antihypertensive dementia prevention trial |
| title_full_unstemmed | Perspectives of general practitioners and memory clinic patients on ageing and cognitive decline to inform the design of a decentralised antihypertensive dementia prevention trial |
| title_short | Perspectives of general practitioners and memory clinic patients on ageing and cognitive decline to inform the design of a decentralised antihypertensive dementia prevention trial |
| title_sort | perspectives of general practitioners and memory clinic patients on ageing and cognitive decline to inform the design of a decentralised antihypertensive dementia prevention trial |
| topic | Dementia Interview Focus group Dementia prevention Blood pressure Trial design |
| url | http://www.sciencedirect.com/science/article/pii/S2666245024000163 |
| work_keys_str_mv | AT alexandrahurden perspectivesofgeneralpractitionersandmemoryclinicpatientsonageingandcognitivedeclinetoinformthedesignofadecentralisedantihypertensivedementiapreventiontrial AT isabellacotter perspectivesofgeneralpractitionersandmemoryclinicpatientsonageingandcognitivedeclinetoinformthedesignofadecentralisedantihypertensivedementiapreventiontrial AT lorenmowszowski perspectivesofgeneralpractitionersandmemoryclinicpatientsonageingandcognitivedeclinetoinformthedesignofadecentralisedantihypertensivedementiapreventiontrial AT sharonnaismith perspectivesofgeneralpractitionersandmemoryclinicpatientsonageingandcognitivedeclinetoinformthedesignofadecentralisedantihypertensivedementiapreventiontrial AT craigsanderson perspectivesofgeneralpractitionersandmemoryclinicpatientsonageingandcognitivedeclinetoinformthedesignofadecentralisedantihypertensivedementiapreventiontrial |