Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central Africa
The Joint United Nations Program on HIV/AIDS (UNAIDS) has adopted the Sustainable Development Goals (SDGs) to end the HIV/AIDS epidemic by 2030. Several factors related to the non-suppression of HIV, including interruptions of antiretroviral therapy (ART) and opportunistic infections could affect an...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/12/2808 |
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| author | Eldridge Fedricksen Oloumbou Jéordy Dimitri Engone-Ondo Issakou Mamimandjiami Idam Pamela Moussavou-Boudzanga Ivan Mfouo-Tynga Augustin Mouinga-Ondeme |
| author_facet | Eldridge Fedricksen Oloumbou Jéordy Dimitri Engone-Ondo Issakou Mamimandjiami Idam Pamela Moussavou-Boudzanga Ivan Mfouo-Tynga Augustin Mouinga-Ondeme |
| author_sort | Eldridge Fedricksen Oloumbou |
| collection | DOAJ |
| description | The Joint United Nations Program on HIV/AIDS (UNAIDS) has adopted the Sustainable Development Goals (SDGs) to end the HIV/AIDS epidemic by 2030. Several factors related to the non-suppression of HIV, including interruptions of antiretroviral therapy (ART) and opportunistic infections could affect and delay this projected epidemic goal. Human T-Cell leukemia virus type 1 (HTLV-1) appears to be consistently associated with a high risk of opportunistic infections, an early onset of HTLV-1 and its associated pathologies, as well as a fast progression to the AIDS phase in co-infected individuals, when compared to HIV-1 or HTLV-1 mono-infected individuals. In Gabon, the prevalence of these two retroviruses is very high and little is known about HTLV-1 and the associated pathologies, leaving most of them underdiagnosed. Hence, HTLV-1/HIV-1 co-infections could simultaneously imply a non-diagnosis of HIV-1 positive individuals having developed pathologies associated with HTLV-1, but also a high mortality rate among the co-infected individuals. All of these constitute potential obstacles to pursue targeted objectives. A systematic review was conducted to assess the negative impacts of HTLV-1/HIV-1 co-infections and related factors on the elimination of HIV/AIDS by 2030 in Gabon. |
| first_indexed | 2024-03-09T15:44:39Z |
| format | Article |
| id | doaj.art-4b1e838bb58a4d2ab912bed629d2f310 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T15:44:39Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-4b1e838bb58a4d2ab912bed629d2f3102023-11-24T18:40:02ZengMDPI AGViruses1999-49152022-12-011412280810.3390/v14122808Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central AfricaEldridge Fedricksen Oloumbou0Jéordy Dimitri Engone-Ondo1Issakou Mamimandjiami Idam2Pamela Moussavou-Boudzanga3Ivan Mfouo-Tynga4Augustin Mouinga-Ondeme5Unité des Infection Rétrovirales et Pathologies Associées, Centre International de Recherches Médicales de Franceville (CIRMF), Franceville BP 769, GabonUnité des Infection Rétrovirales et Pathologies Associées, Centre International de Recherches Médicales de Franceville (CIRMF), Franceville BP 769, GabonUnité des Infection Rétrovirales et Pathologies Associées, Centre International de Recherches Médicales de Franceville (CIRMF), Franceville BP 769, GabonUnité des Infection Rétrovirales et Pathologies Associées, Centre International de Recherches Médicales de Franceville (CIRMF), Franceville BP 769, GabonUnité des Infection Rétrovirales et Pathologies Associées, Centre International de Recherches Médicales de Franceville (CIRMF), Franceville BP 769, GabonUnité des Infection Rétrovirales et Pathologies Associées, Centre International de Recherches Médicales de Franceville (CIRMF), Franceville BP 769, GabonThe Joint United Nations Program on HIV/AIDS (UNAIDS) has adopted the Sustainable Development Goals (SDGs) to end the HIV/AIDS epidemic by 2030. Several factors related to the non-suppression of HIV, including interruptions of antiretroviral therapy (ART) and opportunistic infections could affect and delay this projected epidemic goal. Human T-Cell leukemia virus type 1 (HTLV-1) appears to be consistently associated with a high risk of opportunistic infections, an early onset of HTLV-1 and its associated pathologies, as well as a fast progression to the AIDS phase in co-infected individuals, when compared to HIV-1 or HTLV-1 mono-infected individuals. In Gabon, the prevalence of these two retroviruses is very high and little is known about HTLV-1 and the associated pathologies, leaving most of them underdiagnosed. Hence, HTLV-1/HIV-1 co-infections could simultaneously imply a non-diagnosis of HIV-1 positive individuals having developed pathologies associated with HTLV-1, but also a high mortality rate among the co-infected individuals. All of these constitute potential obstacles to pursue targeted objectives. A systematic review was conducted to assess the negative impacts of HTLV-1/HIV-1 co-infections and related factors on the elimination of HIV/AIDS by 2030 in Gabon.https://www.mdpi.com/1999-4915/14/12/2808HIV-1HTLV-1coinfectiongenetic diversityHTLV-1-associated pathologiesHIV elimination |
| spellingShingle | Eldridge Fedricksen Oloumbou Jéordy Dimitri Engone-Ondo Issakou Mamimandjiami Idam Pamela Moussavou-Boudzanga Ivan Mfouo-Tynga Augustin Mouinga-Ondeme Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central Africa Viruses HIV-1 HTLV-1 coinfection genetic diversity HTLV-1-associated pathologies HIV elimination |
| title | Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central Africa |
| title_full | Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central Africa |
| title_fullStr | Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central Africa |
| title_full_unstemmed | Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central Africa |
| title_short | Human T-Cell Leukemia Virus Type 1-Related Diseases May Constitute a Threat to the Elimination of Human Immunodeficiency Virus, by 2030, in Gabon, Central Africa |
| title_sort | human t cell leukemia virus type 1 related diseases may constitute a threat to the elimination of human immunodeficiency virus by 2030 in gabon central africa |
| topic | HIV-1 HTLV-1 coinfection genetic diversity HTLV-1-associated pathologies HIV elimination |
| url | https://www.mdpi.com/1999-4915/14/12/2808 |
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