Small-molecule-mediated reprogramming: a silver lining for regenerative medicine
Regenerative medicine: Harnessing the reprogramming power of small molecules The reprogramming of cells using small molecules to generate viable, safe stem-cell populations could transform stem-cell therapies, disease modeling and artificial organ development. Existing ways of reprogramming cells to...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-02-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-020-0383-3 |
| _version_ | 1819284992818151424 |
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| author | Yohan Kim Jaemin Jeong Dongho Choi |
| author_facet | Yohan Kim Jaemin Jeong Dongho Choi |
| author_sort | Yohan Kim |
| collection | DOAJ |
| description | Regenerative medicine: Harnessing the reprogramming power of small molecules The reprogramming of cells using small molecules to generate viable, safe stem-cell populations could transform stem-cell therapies, disease modeling and artificial organ development. Existing ways of reprogramming cells to generate stem cells carry risks, because the methods used often involve using viral DNA components or oncogenes, genes with the potential to turn cells into tumour cells. Safer, inexpensive alternatives are sought by scientists, and the efficient reprogramming of cells using small molecules and growth factors shows promise. Dongho Choi and co-workers at Hanyang University College of Medicine in Seoul, South Korea, reviewed recent research highlighting how small molecules including chemical compounds, plant derivatives and certain approved drugs are being used effectively to create different stem-cell populations. Recent successes are also contributing valuable insights into how stem cells differentiate into different cell types. |
| first_indexed | 2024-12-24T01:56:11Z |
| format | Article |
| id | doaj.art-4b1f5c95fe4e407f8dedd427ed2b35c7 |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-24T01:56:11Z |
| publishDate | 2020-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-4b1f5c95fe4e407f8dedd427ed2b35c72022-12-21T17:21:33ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132020-02-0152221322610.1038/s12276-020-0383-3Small-molecule-mediated reprogramming: a silver lining for regenerative medicineYohan Kim0Jaemin Jeong1Dongho Choi2Department of Surgery, Hanyang University College of MedicineDepartment of Surgery, Hanyang University College of MedicineDepartment of Surgery, Hanyang University College of MedicineRegenerative medicine: Harnessing the reprogramming power of small molecules The reprogramming of cells using small molecules to generate viable, safe stem-cell populations could transform stem-cell therapies, disease modeling and artificial organ development. Existing ways of reprogramming cells to generate stem cells carry risks, because the methods used often involve using viral DNA components or oncogenes, genes with the potential to turn cells into tumour cells. Safer, inexpensive alternatives are sought by scientists, and the efficient reprogramming of cells using small molecules and growth factors shows promise. Dongho Choi and co-workers at Hanyang University College of Medicine in Seoul, South Korea, reviewed recent research highlighting how small molecules including chemical compounds, plant derivatives and certain approved drugs are being used effectively to create different stem-cell populations. Recent successes are also contributing valuable insights into how stem cells differentiate into different cell types.https://doi.org/10.1038/s12276-020-0383-3 |
| spellingShingle | Yohan Kim Jaemin Jeong Dongho Choi Small-molecule-mediated reprogramming: a silver lining for regenerative medicine Experimental and Molecular Medicine |
| title | Small-molecule-mediated reprogramming: a silver lining for regenerative medicine |
| title_full | Small-molecule-mediated reprogramming: a silver lining for regenerative medicine |
| title_fullStr | Small-molecule-mediated reprogramming: a silver lining for regenerative medicine |
| title_full_unstemmed | Small-molecule-mediated reprogramming: a silver lining for regenerative medicine |
| title_short | Small-molecule-mediated reprogramming: a silver lining for regenerative medicine |
| title_sort | small molecule mediated reprogramming a silver lining for regenerative medicine |
| url | https://doi.org/10.1038/s12276-020-0383-3 |
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