Towards the Small and the Beautiful: A Small Dibromotyrosine Derivative from Pseudoceratina sp. Sponge Exhibits Potent Apoptotic Effect through Targeting IKK/NFκB Signaling Pathway
A dibromotyrosine derivative, (1′R,5′S,6′S)-2-(3′,5′-dibromo-1′,6′-dihydroxy-4′-oxocyclohex-2′-enyl) acetonitrile (DT), was isolated from the sponge Pseudoceratina sp., and was found to exhibit a significant cytotoxic activity against leukemia K562 cells. Despite the large number of the isolated bro...
Main Authors: | Michael Y. Chiang, Yao-Tsung Yeh, Mei-Chin Lu, Yin-Di Su, Wen-Been Chang, Yalan Chou, Chia-Wei Tsao, Li-Lian Liu, Ying-Chi Du, Chiang-Wen Su, Yu-Cheng Chen, Mohamed El-Shazly, Jui-Hsin Su |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2013-08-01
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Series: | Marine Drugs |
Subjects: | |
Online Access: | http://www.mdpi.com/1660-3397/11/9/3168 |
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