Prevalence of eosinophilic esophagitis: A multicenter study on a pediatric population evaluated at thirty-six Latin American gastroenterology centers
Introduction and objective: Eosinophilic esophagitis is a chronic, immune-mediated disease described in case series and publications worldwide. Over the past twenty years, the authors of different studies have attempted to evaluate its incidence and prevalence. The objetive of the present study was...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-10-01
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| Series: | Revista de Gastroenterología de México (English Edition) |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255534X18301427 |
| _version_ | 1828871376767811584 |
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| author | R. Pierre M. Vieira R. Vázquez I. Ninomiya G. Messere W. Daza S. Dadan M. Higuera L. Sifontes P. Harris J.C. Gana M. Rodríguez M. Vasquez M. González J. Rivera J. Gonzales D. Angulo M.D. Cetraro M. Del Compare K. López D. Navarro R. Calva M. Wagener R. Zablah A. Carias O. Calderón J.F. Vera-Chamorro M.C. Toca M.R. Dewaele C. Iglesias L. Delgado K. León I. Hassan F. Ussher F. Follett V. Bernedo V. Grinblat N. Agüero C. Oviedo A.G. García A. Salazar P. Coello R. Furnes M. Menchaca M. Fernández A. Khoury C. Rojo S. Fernández C. Morao |
| author_facet | R. Pierre M. Vieira R. Vázquez I. Ninomiya G. Messere W. Daza S. Dadan M. Higuera L. Sifontes P. Harris J.C. Gana M. Rodríguez M. Vasquez M. González J. Rivera J. Gonzales D. Angulo M.D. Cetraro M. Del Compare K. López D. Navarro R. Calva M. Wagener R. Zablah A. Carias O. Calderón J.F. Vera-Chamorro M.C. Toca M.R. Dewaele C. Iglesias L. Delgado K. León I. Hassan F. Ussher F. Follett V. Bernedo V. Grinblat N. Agüero C. Oviedo A.G. García A. Salazar P. Coello R. Furnes M. Menchaca M. Fernández A. Khoury C. Rojo S. Fernández C. Morao |
| author_sort | R. Pierre |
| collection | DOAJ |
| description | Introduction and objective: Eosinophilic esophagitis is a chronic, immune-mediated disease described in case series and publications worldwide. Over the past twenty years, the authors of different studies have attempted to evaluate its incidence and prevalence. The objetive of the present study was to estimate the prevalence of eosinophilic esophagitis in a group of children seen at 36 pediatric gastroenterology centers in ten Latin American countries. Materials and methods: A multicenter, observational, and cross-sectional study was conducted that estimated the period prevalence of eosinophilic esophagitis in children seen at outpatient consultation and that underwent diagnostic upper gastrointestinal endoscopy for any indication at 36 centers in 10 Latin American countries, within a 3-month time frame. Results: Between April and June 2016, 108 cases of eosinophilic esophagitis were evaluated. Likewise, an average of 29,253 outpatient consultations and 4,152 diagnostic upper gastrointestinal endoscopies were carried out at the 36 participating centers. The period prevalence of eosinophilic esophagitis in the population studied (n = 29,253) was 3.69 cases × 1,000 (95% CI: 3.04 to 4.44), and among the children that underwent routine upper gastrointestinal endoscopy (n = 4,152), it was 26 x 1,000 (95% CI: 22.6 to 29.4). Conclusions: The general period prevalence of eosinophilic esophagitis in a group of children evaluated at 36 Latin American pediatric gastroenterology centers was 3.69 × 1,000, and in the children that underwent endoscopy, it was 26 × 1,000. There was important prevalence variability between the participating countries and centers. The present analysis is the first study conducted on the prevalence of pediatric eosinophilic esophagitis in Latin America. Resumen: Introducción y objetivo: La esofagitis eosinofílica es una enfermedad crónica, mediada inmunológicamente, descrita en series y publicaciones alrededor del mundo. En los últimos 20 años diversos estudios han intentado evaluar la incidencia y prevalencia de la enfermedad. El objetivo del presente trabajo es estimar la prevalencia de esofagitis eosinofílica en un grupo de niños atendidos en 36 centros de gastroenterología pediátrica de 10 países latinoamericanos. Materiales y métodos: A través de un protocolo multicéntrico, observacional y transversal se estimó la prevalencia de período de esofagitis eosinofílica entre los niños atendidos en consulta externa y sometidos a endoscopia superior diagnóstica por cualquier motivo en 36 centros de 10 países latinoamericanos durante un período de 3 meses. Resultados: Entre abril y junio de 2016 108 casos de esofagitis eosinofílica fueron evaluados. Asimismo, un promedio de 29,253 consultas ambulatorias y 4,152 endoscopias superiores de carácter diagnóstico fueron realizadas en los 36 centros participantes. La tasa de prevalencia de esofagitis eosinofílica en la población estudiada (n = 29,253) fue de 3,69 casos × 1,000 (IC 95%: 3.04 a 4.44) y entre los niños sometidos a endoscopia superior de rutina (n = 4,152) fue de 26 x 1,000 (IC 95%: 22.6 a 29.4). Conclusión: La tasa general de prevalencia de período de esofagitis eosinofílica en un grupo de niños evaluados en 36 centros latinoamericanos de gastroenterología pediátrica resultó de 3,69 × 1,000, y entre aquellos sometidos a endoscopia fue de 26 × 1,000. La prevalencia mostró una importante variabilidad entre los países y centros participantes. Este es el primer estudio de prevalencia de esofagitis eosinofílica pediátrica en Latinoamérica. Keywords: Esophagitis, Eosinophilic, Children, Prevalence, Latin America, Palabras clave: Esofagitis, Eosinofílica, Niños, Prevalencia, Latinoamérica |
| first_indexed | 2024-12-13T06:31:55Z |
| format | Article |
| id | doaj.art-4b235fe27ebd45508768b6de9b49756a |
| institution | Directory Open Access Journal |
| issn | 2255-534X |
| language | English |
| last_indexed | 2024-12-13T06:31:55Z |
| publishDate | 2019-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista de Gastroenterología de México (English Edition) |
| spelling | doaj.art-4b235fe27ebd45508768b6de9b49756a2022-12-21T23:56:36ZengElsevierRevista de Gastroenterología de México (English Edition)2255-534X2019-10-01844427433Prevalence of eosinophilic esophagitis: A multicenter study on a pediatric population evaluated at thirty-six Latin American gastroenterology centersR. Pierre0M. Vieira1R. Vázquez2I. Ninomiya3G. Messere4W. Daza5S. Dadan6M. Higuera7L. Sifontes8P. Harris9J.C. Gana10M. Rodríguez11M. Vasquez12M. González13J. Rivera14J. Gonzales15D. Angulo16M.D. Cetraro17M. Del Compare18K. López19D. Navarro20R. Calva21M. Wagener22R. Zablah23A. Carias24O. Calderón25J.F. Vera-Chamorro26M.C. Toca27M.R. Dewaele28C. Iglesias29L. Delgado30K. León31I. Hassan32F. Ussher33F. Follett34V. Bernedo35V. Grinblat36N. Agüero37C. Oviedo38A.G. García39A. Salazar40P. Coello41R. Furnes42M. Menchaca43M. Fernández44A. Khoury45C. Rojo46S. Fernández47C. Morao48Clínica Razetti, Barquisimeto, Venezuela; Corresponding author. Clínica Razetti, Barquisimeto, Carrera 21, Barquisimeto 3001, Lara, Venezuela. Tel.: +58(251)7105759.Hospital Pequeño Príncipe, Curitiba, BrazilHospital Infantil de México Federico Gómez, Mexico City, MexicoHospital Italiano, Buenos Aires, ArgentinaHospital Nacional Alejandro Posadas, Buenos Aires, ArgentinaUnidad de Gastroenterología Pediátrica y Nutrición, Gastronutriped, Bogotá, ColombiaUnidad de Gastroenterología Pediátrica y Nutrición, Gastronutriped, Bogotá, ColombiaUnidad de Gastroenterología Pediátrica y Nutrición, Gastronutriped, Bogotá, ColombiaCentro Médico El Valle, Porlamar, VenezuelaPontificia Universidad Católica, Santiago, ChilePontificia Universidad Católica, Santiago, ChileHospital de Niños Dr. J.M. de Los Ríos, Caracas, VenezuelaHospital Universitario de Pediatría Dr. Agustín Zubillaga, Barquisimeto, VenezuelaHospital Dr. Roberto del Río, Santiago, ChileInstituto Nacional de Salud del Niño, Lima, Peru; Clínica Ricardo Palma, Lima, PeruInstituto Nacional de Salud del Niño, Lima, Peru; Clínica Ricardo Palma, Lima, PeruHospital Nacional Docente Madre Niño San Bartolomé, Lima, PeruHospital Nacional Docente Madre Niño San Bartolomé, Lima, PeruHospital Mater Dei, Buenos Aires, ArgentinaHospital Dr. Miguel Pérez Carreño, Caracas, VenezuelaHospital Dr. Miguel Pérez Carreño, Caracas, VenezuelaFacultad de Medicina BUAP, Puebla, MexicoHospital de Niños Dr. O. Alassia, Santa Fe, ArgentinaClínica de Gastroenterología, Endoscopia y Nutrición Pediátrica Multipediátrica, San Salvador, El SalvadorFundación Santa Fe de Bogotá, Bogotá, ColombiaClínica Farallones-Gastroped, Cali, ColombiaFundación Santa Fe de Bogotá, Bogotá, ColombiaHospital Nacional Alejandro Posadas, Buenos Aires, ArgentinaHospital Pereira Rossel, Montevideo, UruguayHospital Pereira Rossel, Montevideo, UruguayHospital Pereira Rossel, Montevideo, UruguayPoliclínica Metropolitana, Caracas, VenezuelaPoliclínica Metropolitana, Caracas, VenezuelaHospital Universitario Austral, Buenos Aires, ArgentinaHospital Universitario Austral, Buenos Aires, ArgentinaHospital de Niños Sor María Ludovica, La Plata, ArgentinaClínica Universitaria Reina Fabiola, Córdoba, ArgentinaClínica Universitaria Reina Fabiola, Córdoba, ArgentinaHospital Vozandes, Quito, EcuadorGastroclínica, San Salvador, El SalvadorHospital Central Ignacio Morones Prieto, San Luis Potosí, MexicoHospital Civil Juan I. Menchaca, Guadalajara, MexicoHospital Privado Universitario de Córdoba, Córdoba, ArgentinaHospital Universitario UANL, Monterrey, MexicoHospital Dr. Manuel Antonio Narváez, Porlamar, VenezuelaCentro Policlínico Valencia, Valencia, VenezuelaHospital Regional Leonardo Guzmán, Antofagasta, ChileTecSalud, Monterrey, MexicoHospital de Niños Dr. J.M. de Los Ríos, Caracas, VenezuelaIntroduction and objective: Eosinophilic esophagitis is a chronic, immune-mediated disease described in case series and publications worldwide. Over the past twenty years, the authors of different studies have attempted to evaluate its incidence and prevalence. The objetive of the present study was to estimate the prevalence of eosinophilic esophagitis in a group of children seen at 36 pediatric gastroenterology centers in ten Latin American countries. Materials and methods: A multicenter, observational, and cross-sectional study was conducted that estimated the period prevalence of eosinophilic esophagitis in children seen at outpatient consultation and that underwent diagnostic upper gastrointestinal endoscopy for any indication at 36 centers in 10 Latin American countries, within a 3-month time frame. Results: Between April and June 2016, 108 cases of eosinophilic esophagitis were evaluated. Likewise, an average of 29,253 outpatient consultations and 4,152 diagnostic upper gastrointestinal endoscopies were carried out at the 36 participating centers. The period prevalence of eosinophilic esophagitis in the population studied (n = 29,253) was 3.69 cases × 1,000 (95% CI: 3.04 to 4.44), and among the children that underwent routine upper gastrointestinal endoscopy (n = 4,152), it was 26 x 1,000 (95% CI: 22.6 to 29.4). Conclusions: The general period prevalence of eosinophilic esophagitis in a group of children evaluated at 36 Latin American pediatric gastroenterology centers was 3.69 × 1,000, and in the children that underwent endoscopy, it was 26 × 1,000. There was important prevalence variability between the participating countries and centers. The present analysis is the first study conducted on the prevalence of pediatric eosinophilic esophagitis in Latin America. Resumen: Introducción y objetivo: La esofagitis eosinofílica es una enfermedad crónica, mediada inmunológicamente, descrita en series y publicaciones alrededor del mundo. En los últimos 20 años diversos estudios han intentado evaluar la incidencia y prevalencia de la enfermedad. El objetivo del presente trabajo es estimar la prevalencia de esofagitis eosinofílica en un grupo de niños atendidos en 36 centros de gastroenterología pediátrica de 10 países latinoamericanos. Materiales y métodos: A través de un protocolo multicéntrico, observacional y transversal se estimó la prevalencia de período de esofagitis eosinofílica entre los niños atendidos en consulta externa y sometidos a endoscopia superior diagnóstica por cualquier motivo en 36 centros de 10 países latinoamericanos durante un período de 3 meses. Resultados: Entre abril y junio de 2016 108 casos de esofagitis eosinofílica fueron evaluados. Asimismo, un promedio de 29,253 consultas ambulatorias y 4,152 endoscopias superiores de carácter diagnóstico fueron realizadas en los 36 centros participantes. La tasa de prevalencia de esofagitis eosinofílica en la población estudiada (n = 29,253) fue de 3,69 casos × 1,000 (IC 95%: 3.04 a 4.44) y entre los niños sometidos a endoscopia superior de rutina (n = 4,152) fue de 26 x 1,000 (IC 95%: 22.6 a 29.4). Conclusión: La tasa general de prevalencia de período de esofagitis eosinofílica en un grupo de niños evaluados en 36 centros latinoamericanos de gastroenterología pediátrica resultó de 3,69 × 1,000, y entre aquellos sometidos a endoscopia fue de 26 × 1,000. La prevalencia mostró una importante variabilidad entre los países y centros participantes. Este es el primer estudio de prevalencia de esofagitis eosinofílica pediátrica en Latinoamérica. Keywords: Esophagitis, Eosinophilic, Children, Prevalence, Latin America, Palabras clave: Esofagitis, Eosinofílica, Niños, Prevalencia, Latinoaméricahttp://www.sciencedirect.com/science/article/pii/S2255534X18301427 |
| spellingShingle | R. Pierre M. Vieira R. Vázquez I. Ninomiya G. Messere W. Daza S. Dadan M. Higuera L. Sifontes P. Harris J.C. Gana M. Rodríguez M. Vasquez M. González J. Rivera J. Gonzales D. Angulo M.D. Cetraro M. Del Compare K. López D. Navarro R. Calva M. Wagener R. Zablah A. Carias O. Calderón J.F. Vera-Chamorro M.C. Toca M.R. Dewaele C. Iglesias L. Delgado K. León I. Hassan F. Ussher F. Follett V. Bernedo V. Grinblat N. Agüero C. Oviedo A.G. García A. Salazar P. Coello R. Furnes M. Menchaca M. Fernández A. Khoury C. Rojo S. Fernández C. Morao Prevalence of eosinophilic esophagitis: A multicenter study on a pediatric population evaluated at thirty-six Latin American gastroenterology centers Revista de Gastroenterología de México (English Edition) |
| title | Prevalence of eosinophilic esophagitis: A multicenter study on a pediatric population evaluated at thirty-six Latin American gastroenterology centers |
| title_full | Prevalence of eosinophilic esophagitis: A multicenter study on a pediatric population evaluated at thirty-six Latin American gastroenterology centers |
| title_fullStr | Prevalence of eosinophilic esophagitis: A multicenter study on a pediatric population evaluated at thirty-six Latin American gastroenterology centers |
| title_full_unstemmed | Prevalence of eosinophilic esophagitis: A multicenter study on a pediatric population evaluated at thirty-six Latin American gastroenterology centers |
| title_short | Prevalence of eosinophilic esophagitis: A multicenter study on a pediatric population evaluated at thirty-six Latin American gastroenterology centers |
| title_sort | prevalence of eosinophilic esophagitis a multicenter study on a pediatric population evaluated at thirty six latin american gastroenterology centers |
| url | http://www.sciencedirect.com/science/article/pii/S2255534X18301427 |
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