Radiotherapy-induced enrichment of EGF-modified doxorubicin nanoparticles enhances the therapeutic outcome of lung cancer
Chemotherapy is the primary treatment for advanced non-small-cell lung cancer (NSCLC). However, related dose-dependent toxicity limits its clinical use. Therefore, it is necessary to explore new strategies for improving the clinical outcomes while reducing the side effects of chemotherapy in the tre...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2022.2036871 |
| _version_ | 1818872255848906752 |
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| author | Jing Wang Yan Zhang GuangPeng Zhang Li Xiang HaoWen Pang Kang Xiong Yun Lu JianMei Li Jie Dai Sheng Lin ShaoZhi Fu |
| author_facet | Jing Wang Yan Zhang GuangPeng Zhang Li Xiang HaoWen Pang Kang Xiong Yun Lu JianMei Li Jie Dai Sheng Lin ShaoZhi Fu |
| author_sort | Jing Wang |
| collection | DOAJ |
| description | Chemotherapy is the primary treatment for advanced non-small-cell lung cancer (NSCLC). However, related dose-dependent toxicity limits its clinical use. Therefore, it is necessary to explore new strategies for improving the clinical outcomes while reducing the side effects of chemotherapy in the treatment of NSCLC. In this study, we designed and synthesized epidermal growth factor (EGF)-modified doxorubicin nanoparticles (EGF@DOX-NPs) that selectively targets the epidermal growth factor receptor (EGFR) overexpressed in lung tumor cells. When administered in combination with low-dose X-ray radiotherapy (RT), the NPs preferentially accumulated at the tumor site due to radiation-induced outburst of the local intra-tumoral blood vessels. Compared with DOX alone, EGF@DOX-NPs significantly decreased the viability and migration and enhanced the apoptosis rates of tumor cells in vitro. Also, the EGF@DOX-NPs significantly inhibited tumor growth in vivo, increasing the survival of the tumor-bearing mice without apparent systemic toxic effects through RT-induced aggregation. The tumor cell proliferation was greatly inhibited in the RT + EGF@DOX-NPs group. Contrarily, the apoptosis of tumor cells was significantly higher in this group. These results confirm the promising clinical application of radiotherapy in combination with EGF@DOX-NPs for lung cancer treatment. |
| first_indexed | 2024-12-19T12:35:55Z |
| format | Article |
| id | doaj.art-4b2459a85baf49588da1071d5389bb5d |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-19T12:35:55Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-4b2459a85baf49588da1071d5389bb5d2022-12-21T20:21:09ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642022-12-0129158859910.1080/10717544.2022.20368712036871Radiotherapy-induced enrichment of EGF-modified doxorubicin nanoparticles enhances the therapeutic outcome of lung cancerJing Wang0Yan Zhang1GuangPeng Zhang2Li Xiang3HaoWen Pang4Kang Xiong5Yun Lu6JianMei Li7Jie Dai8Sheng Lin9ShaoZhi Fu10Department of Oncology, the Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, The Affiliated TCM Hospital of Southwest Medical UniversityDepartment of Oncology, the Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, the Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, the Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, the Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, the Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, the Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, the Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, the Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, the Affiliated Hospital of Southwest Medical UniversityChemotherapy is the primary treatment for advanced non-small-cell lung cancer (NSCLC). However, related dose-dependent toxicity limits its clinical use. Therefore, it is necessary to explore new strategies for improving the clinical outcomes while reducing the side effects of chemotherapy in the treatment of NSCLC. In this study, we designed and synthesized epidermal growth factor (EGF)-modified doxorubicin nanoparticles (EGF@DOX-NPs) that selectively targets the epidermal growth factor receptor (EGFR) overexpressed in lung tumor cells. When administered in combination with low-dose X-ray radiotherapy (RT), the NPs preferentially accumulated at the tumor site due to radiation-induced outburst of the local intra-tumoral blood vessels. Compared with DOX alone, EGF@DOX-NPs significantly decreased the viability and migration and enhanced the apoptosis rates of tumor cells in vitro. Also, the EGF@DOX-NPs significantly inhibited tumor growth in vivo, increasing the survival of the tumor-bearing mice without apparent systemic toxic effects through RT-induced aggregation. The tumor cell proliferation was greatly inhibited in the RT + EGF@DOX-NPs group. Contrarily, the apoptosis of tumor cells was significantly higher in this group. These results confirm the promising clinical application of radiotherapy in combination with EGF@DOX-NPs for lung cancer treatment.http://dx.doi.org/10.1080/10717544.2022.2036871doxorubicinnanoparticlesegflung cancerradiotherapy |
| spellingShingle | Jing Wang Yan Zhang GuangPeng Zhang Li Xiang HaoWen Pang Kang Xiong Yun Lu JianMei Li Jie Dai Sheng Lin ShaoZhi Fu Radiotherapy-induced enrichment of EGF-modified doxorubicin nanoparticles enhances the therapeutic outcome of lung cancer Drug Delivery doxorubicin nanoparticles egf lung cancer radiotherapy |
| title | Radiotherapy-induced enrichment of EGF-modified doxorubicin nanoparticles enhances the therapeutic outcome of lung cancer |
| title_full | Radiotherapy-induced enrichment of EGF-modified doxorubicin nanoparticles enhances the therapeutic outcome of lung cancer |
| title_fullStr | Radiotherapy-induced enrichment of EGF-modified doxorubicin nanoparticles enhances the therapeutic outcome of lung cancer |
| title_full_unstemmed | Radiotherapy-induced enrichment of EGF-modified doxorubicin nanoparticles enhances the therapeutic outcome of lung cancer |
| title_short | Radiotherapy-induced enrichment of EGF-modified doxorubicin nanoparticles enhances the therapeutic outcome of lung cancer |
| title_sort | radiotherapy induced enrichment of egf modified doxorubicin nanoparticles enhances the therapeutic outcome of lung cancer |
| topic | doxorubicin nanoparticles egf lung cancer radiotherapy |
| url | http://dx.doi.org/10.1080/10717544.2022.2036871 |
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