White Adipose Tissue Heterogeneity in the Single-Cell Era: From Mice and Humans to Cattle
Adipose tissue is a major modulator of metabolic function by regulating energy storage and by acting as an endocrine organ through the secretion of adipokines. With the advantage of next-generation sequencing-based single-cell technologies, adipose tissue has been studied at single-cell resolution,...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/10/1289 |
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| author | Hunter Ford Qianglin Liu Xing Fu Clarissa Strieder-Barboza |
| author_facet | Hunter Ford Qianglin Liu Xing Fu Clarissa Strieder-Barboza |
| author_sort | Hunter Ford |
| collection | DOAJ |
| description | Adipose tissue is a major modulator of metabolic function by regulating energy storage and by acting as an endocrine organ through the secretion of adipokines. With the advantage of next-generation sequencing-based single-cell technologies, adipose tissue has been studied at single-cell resolution, thus providing unbiased insight into its molecular composition. Recent single-cell RNA sequencing studies in human and mouse models have dissected the transcriptional cellular heterogeneity of subcutaneous (SAT), visceral (VAT), and intramuscular (IMAT) white adipose tissue depots and revealed unique populations of adipose tissue progenitor cells, mature adipocytes, immune cell, vascular cells, and mesothelial cells that play direct roles on adipose tissue function and the development of metabolic disorders. In livestock species, especially in bovine, significant gaps of knowledge remain in elucidating the roles of adipose tissue cell types and depots on driving the pathogenesis of metabolic disorders and the distinct fat deposition in VAT, SAT, and IMAT in meat animals. This review summarizes the current knowledge on the transcriptional and functional cellular diversity of white adipose tissue revealed by single-cell approaches and highlights the depot-specific function of adipose tissue in different mammalian species, with a particular focus on recent findings and future implications in cattle. |
| first_indexed | 2024-03-10T21:25:20Z |
| format | Article |
| id | doaj.art-4b257f1ecedb484f9dff365756432d81 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T21:25:20Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-4b257f1ecedb484f9dff365756432d812023-11-19T15:43:11ZengMDPI AGBiology2079-77372023-09-011210128910.3390/biology12101289White Adipose Tissue Heterogeneity in the Single-Cell Era: From Mice and Humans to CattleHunter Ford0Qianglin Liu1Xing Fu2Clarissa Strieder-Barboza3Department of Veterinary Sciences, Davis College of Agricultural Sciences and Natural Resources, Texas Tech University, Lubbock, TX 79409, USASchool of Animal Sciences, Agricultural Center, Louisiana State University, Baton Rouge, LA 70803, USASchool of Animal Sciences, Agricultural Center, Louisiana State University, Baton Rouge, LA 70803, USADepartment of Veterinary Sciences, Davis College of Agricultural Sciences and Natural Resources, Texas Tech University, Lubbock, TX 79409, USAAdipose tissue is a major modulator of metabolic function by regulating energy storage and by acting as an endocrine organ through the secretion of adipokines. With the advantage of next-generation sequencing-based single-cell technologies, adipose tissue has been studied at single-cell resolution, thus providing unbiased insight into its molecular composition. Recent single-cell RNA sequencing studies in human and mouse models have dissected the transcriptional cellular heterogeneity of subcutaneous (SAT), visceral (VAT), and intramuscular (IMAT) white adipose tissue depots and revealed unique populations of adipose tissue progenitor cells, mature adipocytes, immune cell, vascular cells, and mesothelial cells that play direct roles on adipose tissue function and the development of metabolic disorders. In livestock species, especially in bovine, significant gaps of knowledge remain in elucidating the roles of adipose tissue cell types and depots on driving the pathogenesis of metabolic disorders and the distinct fat deposition in VAT, SAT, and IMAT in meat animals. This review summarizes the current knowledge on the transcriptional and functional cellular diversity of white adipose tissue revealed by single-cell approaches and highlights the depot-specific function of adipose tissue in different mammalian species, with a particular focus on recent findings and future implications in cattle.https://www.mdpi.com/2079-7737/12/10/1289adiposesingle-cellsequencingcattlelivestocktranscriptional diversity |
| spellingShingle | Hunter Ford Qianglin Liu Xing Fu Clarissa Strieder-Barboza White Adipose Tissue Heterogeneity in the Single-Cell Era: From Mice and Humans to Cattle Biology adipose single-cell sequencing cattle livestock transcriptional diversity |
| title | White Adipose Tissue Heterogeneity in the Single-Cell Era: From Mice and Humans to Cattle |
| title_full | White Adipose Tissue Heterogeneity in the Single-Cell Era: From Mice and Humans to Cattle |
| title_fullStr | White Adipose Tissue Heterogeneity in the Single-Cell Era: From Mice and Humans to Cattle |
| title_full_unstemmed | White Adipose Tissue Heterogeneity in the Single-Cell Era: From Mice and Humans to Cattle |
| title_short | White Adipose Tissue Heterogeneity in the Single-Cell Era: From Mice and Humans to Cattle |
| title_sort | white adipose tissue heterogeneity in the single cell era from mice and humans to cattle |
| topic | adipose single-cell sequencing cattle livestock transcriptional diversity |
| url | https://www.mdpi.com/2079-7737/12/10/1289 |
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