Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy
Diabetic retinopathy (DR) is a microvascular complication of diabetes in the retina. Chronic hyperglycemia damages retinal microvasculature embedded into the extracellular matrix (ECM), causing fluid leakage and ischemic retinal neovascularization. Current treatment strategies include intravitreal a...
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MDPI AG
2021-12-01
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| Online Access: | https://www.mdpi.com/2075-1729/11/12/1421 |
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| author | Shermaine W. Y. Low Tanuja Vaidya Santosh G. K. Gadde Thirumalesh B. Mochi Devesh Kumar Iris S. Kassem Deborah M. Costakos Baseer Ahmad Swaminathan Sethu Arkasubhra Ghosh Shyam S. Chaurasia |
| author_facet | Shermaine W. Y. Low Tanuja Vaidya Santosh G. K. Gadde Thirumalesh B. Mochi Devesh Kumar Iris S. Kassem Deborah M. Costakos Baseer Ahmad Swaminathan Sethu Arkasubhra Ghosh Shyam S. Chaurasia |
| author_sort | Shermaine W. Y. Low |
| collection | DOAJ |
| description | Diabetic retinopathy (DR) is a microvascular complication of diabetes in the retina. Chronic hyperglycemia damages retinal microvasculature embedded into the extracellular matrix (ECM), causing fluid leakage and ischemic retinal neovascularization. Current treatment strategies include intravitreal anti-vascular endothelial growth factor (VEGF) or steroidal injections, laser photocoagulation, or vitrectomy in severe cases. However, treatment may require multiple modalities or repeat treatments due to variable response. Though DR management has achieved great success, improved, long-lasting, and predictable treatments are needed, including new biomarkers and therapeutic approaches. Small-leucine rich proteoglycans, such as decorin, constitute an integral component of retinal endothelial ECM. Therefore, any damage to microvasculature can trigger its antifibrotic and antiangiogenic response against retinal vascular pathologies, including DR. We conducted a cross-sectional study to examine the association between aqueous humor (AH) decorin levels, if any, and severity of DR. A total of 82 subjects (26 control, 56 DR) were recruited. AH was collected and decorin concentrations were measured using an enzyme-linked immunosorbent assay (ELISA). Decorin was significantly increased in the AH of DR subjects compared to controls (<i>p</i> = 0.0034). AH decorin levels were increased in severe DR groups in ETDRS and Gloucestershire classifications. Decorin concentrations also displayed a significant association with visual acuity (LogMAR) measurements. In conclusion, aqueous humor decorin concentrations were found elevated in DR subjects, possibly due to a compensatory response to the retinal microvascular changes during hyperglycemia. |
| first_indexed | 2024-03-10T03:42:52Z |
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| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T03:42:52Z |
| publishDate | 2021-12-01 |
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| record_format | Article |
| series | Life |
| spelling | doaj.art-4b26c095a0644d0c946bbdc0fb94c9582023-11-23T09:15:16ZengMDPI AGLife2075-17292021-12-011112142110.3390/life11121421Decorin Concentrations in Aqueous Humor of Patients with Diabetic RetinopathyShermaine W. Y. Low0Tanuja Vaidya1Santosh G. K. Gadde2Thirumalesh B. Mochi3Devesh Kumar4Iris S. Kassem5Deborah M. Costakos6Baseer Ahmad7Swaminathan Sethu8Arkasubhra Ghosh9Shyam S. Chaurasia10Ocular Immunology and Angiogenesis Lab, Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USAGROW Research Laboratory, Narayana Nethralaya, Bangalore 560099, IndiaVitreo-Retina Services, Narayana Nethralaya, Bangalore 560010, IndiaVitreo-Retina Services, Narayana Nethralaya, Bangalore 560010, IndiaOcular Immunology and Angiogenesis Lab, Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USAOcular Immunology and Angiogenesis Lab, Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USAOcular Immunology and Angiogenesis Lab, Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USAOcular Immunology and Angiogenesis Lab, Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USAGROW Research Laboratory, Narayana Nethralaya, Bangalore 560099, IndiaGROW Research Laboratory, Narayana Nethralaya, Bangalore 560099, IndiaOcular Immunology and Angiogenesis Lab, Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USADiabetic retinopathy (DR) is a microvascular complication of diabetes in the retina. Chronic hyperglycemia damages retinal microvasculature embedded into the extracellular matrix (ECM), causing fluid leakage and ischemic retinal neovascularization. Current treatment strategies include intravitreal anti-vascular endothelial growth factor (VEGF) or steroidal injections, laser photocoagulation, or vitrectomy in severe cases. However, treatment may require multiple modalities or repeat treatments due to variable response. Though DR management has achieved great success, improved, long-lasting, and predictable treatments are needed, including new biomarkers and therapeutic approaches. Small-leucine rich proteoglycans, such as decorin, constitute an integral component of retinal endothelial ECM. Therefore, any damage to microvasculature can trigger its antifibrotic and antiangiogenic response against retinal vascular pathologies, including DR. We conducted a cross-sectional study to examine the association between aqueous humor (AH) decorin levels, if any, and severity of DR. A total of 82 subjects (26 control, 56 DR) were recruited. AH was collected and decorin concentrations were measured using an enzyme-linked immunosorbent assay (ELISA). Decorin was significantly increased in the AH of DR subjects compared to controls (<i>p</i> = 0.0034). AH decorin levels were increased in severe DR groups in ETDRS and Gloucestershire classifications. Decorin concentrations also displayed a significant association with visual acuity (LogMAR) measurements. In conclusion, aqueous humor decorin concentrations were found elevated in DR subjects, possibly due to a compensatory response to the retinal microvascular changes during hyperglycemia.https://www.mdpi.com/2075-1729/11/12/1421diabetic retinopathydecorinSLRPaqueous humorangiogenesisinflammation |
| spellingShingle | Shermaine W. Y. Low Tanuja Vaidya Santosh G. K. Gadde Thirumalesh B. Mochi Devesh Kumar Iris S. Kassem Deborah M. Costakos Baseer Ahmad Swaminathan Sethu Arkasubhra Ghosh Shyam S. Chaurasia Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy Life diabetic retinopathy decorin SLRP aqueous humor angiogenesis inflammation |
| title | Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy |
| title_full | Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy |
| title_fullStr | Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy |
| title_full_unstemmed | Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy |
| title_short | Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy |
| title_sort | decorin concentrations in aqueous humor of patients with diabetic retinopathy |
| topic | diabetic retinopathy decorin SLRP aqueous humor angiogenesis inflammation |
| url | https://www.mdpi.com/2075-1729/11/12/1421 |
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