Analysis of Ischemia-Modified Albumin (IMA) and Coagulation Parameters in Patients with SARS-CoV-2 Pneumonia
Background: Coronavirus disease 2019 (COVID-19) is a systemic disease which causes an increased inclination to thrombosis by leading to coagulation system activation and endothelial dysfunction. Our objective in this study is to determine whether ischemia-modified albumin (IMA) can be used as a new...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/13/4304 |
| _version_ | 1797591409279107072 |
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| author | Emel Saglam Gulsen Sener Tulin Bayrak Ahmet Bayrak Numan Gorgulu |
| author_facet | Emel Saglam Gulsen Sener Tulin Bayrak Ahmet Bayrak Numan Gorgulu |
| author_sort | Emel Saglam |
| collection | DOAJ |
| description | Background: Coronavirus disease 2019 (COVID-19) is a systemic disease which causes an increased inclination to thrombosis by leading to coagulation system activation and endothelial dysfunction. Our objective in this study is to determine whether ischemia-modified albumin (IMA) can be used as a new marker in patients with COVID-19 for evaluating the increased coagulation risk, pneumonic infiltration, and thus, prognosis. Methods: Our study included 59 patients with COVID-19 compatible pneumonic infiltration on lung computed tomography (CT) who applied to and were hospitalized in the Internal Diseases Outpatient Clinic, then followed up and treated, as well as 29 healthy individuals with a negative COVID-19 rRT-PCR test without any additional disease. Hemogram, coagulation, routine biochemistry, and serum IMA activity parameters were studied. Results: In our study, the higher serum IMA level in COVID-19 patients with pneumonic infiltration compared to that of the healthy control group was found to be statistically significant. No significant correlation was found between the serum IMA levels and the coagulation and inflammation parameters in the 59 COVID-19 patients included. Conclusions: Serum IMA levels in COVID-19 patients with pneumonic infiltration on CT were found to be higher than in the control group. Examination of biochemical parameters, especially thrombotic parameters that affect prognosis such as IMA, can be a guide in estimating pneumonic infiltration. |
| first_indexed | 2024-03-11T01:37:00Z |
| format | Article |
| id | doaj.art-4b27d62a43c34c2eaca0a4333ff7b88c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T01:37:00Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-4b27d62a43c34c2eaca0a4333ff7b88c2023-11-18T16:51:59ZengMDPI AGJournal of Clinical Medicine2077-03832023-06-011213430410.3390/jcm12134304Analysis of Ischemia-Modified Albumin (IMA) and Coagulation Parameters in Patients with SARS-CoV-2 PneumoniaEmel Saglam0Gulsen Sener1Tulin Bayrak2Ahmet Bayrak3Numan Gorgulu4Department of Internal Medicine, Bagcilar Training and Research Hospital, 34200 Istanbul, TurkeyDepartment of Biochemistry, Başakşehir Çam and Sakura City Hospital, 34480 Istanbul, TurkeyDepartment of Biochemistry, Faculty of Medicine, Ordu University, 52200 Ordu, TurkeyDepartment of Biochemistry, Faculty of Medicine, Ordu University, 52200 Ordu, TurkeyDepartment of Internal Medicine, Bagcilar Training and Research Hospital, 34200 Istanbul, TurkeyBackground: Coronavirus disease 2019 (COVID-19) is a systemic disease which causes an increased inclination to thrombosis by leading to coagulation system activation and endothelial dysfunction. Our objective in this study is to determine whether ischemia-modified albumin (IMA) can be used as a new marker in patients with COVID-19 for evaluating the increased coagulation risk, pneumonic infiltration, and thus, prognosis. Methods: Our study included 59 patients with COVID-19 compatible pneumonic infiltration on lung computed tomography (CT) who applied to and were hospitalized in the Internal Diseases Outpatient Clinic, then followed up and treated, as well as 29 healthy individuals with a negative COVID-19 rRT-PCR test without any additional disease. Hemogram, coagulation, routine biochemistry, and serum IMA activity parameters were studied. Results: In our study, the higher serum IMA level in COVID-19 patients with pneumonic infiltration compared to that of the healthy control group was found to be statistically significant. No significant correlation was found between the serum IMA levels and the coagulation and inflammation parameters in the 59 COVID-19 patients included. Conclusions: Serum IMA levels in COVID-19 patients with pneumonic infiltration on CT were found to be higher than in the control group. Examination of biochemical parameters, especially thrombotic parameters that affect prognosis such as IMA, can be a guide in estimating pneumonic infiltration.https://www.mdpi.com/2077-0383/12/13/4304COVID-19ischemia-modified albuminpneumoniathrombosis |
| spellingShingle | Emel Saglam Gulsen Sener Tulin Bayrak Ahmet Bayrak Numan Gorgulu Analysis of Ischemia-Modified Albumin (IMA) and Coagulation Parameters in Patients with SARS-CoV-2 Pneumonia Journal of Clinical Medicine COVID-19 ischemia-modified albumin pneumonia thrombosis |
| title | Analysis of Ischemia-Modified Albumin (IMA) and Coagulation Parameters in Patients with SARS-CoV-2 Pneumonia |
| title_full | Analysis of Ischemia-Modified Albumin (IMA) and Coagulation Parameters in Patients with SARS-CoV-2 Pneumonia |
| title_fullStr | Analysis of Ischemia-Modified Albumin (IMA) and Coagulation Parameters in Patients with SARS-CoV-2 Pneumonia |
| title_full_unstemmed | Analysis of Ischemia-Modified Albumin (IMA) and Coagulation Parameters in Patients with SARS-CoV-2 Pneumonia |
| title_short | Analysis of Ischemia-Modified Albumin (IMA) and Coagulation Parameters in Patients with SARS-CoV-2 Pneumonia |
| title_sort | analysis of ischemia modified albumin ima and coagulation parameters in patients with sars cov 2 pneumonia |
| topic | COVID-19 ischemia-modified albumin pneumonia thrombosis |
| url | https://www.mdpi.com/2077-0383/12/13/4304 |
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