Anaplastic lymphoma kinase positive large B-cell lymphoma mimicking as plasma cell neoplasm: A rare case report
Anaplastic lymphoma kinase positive (ALK+ve) large B-cell lymphoma (LBCL) is a rare, aggressive subtype of diffuse LBCL with unique morphological characteristics and unusual immunophenotypic features that have substantial overlap with other hematologic and nonhematologic neoplasms. Here, we present...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Applied Hematology |
| Subjects: | |
| Online Access: | http://www.jahjournal.org/article.asp?issn=1658-5127;year=2023;volume=14;issue=3;spage=252;epage=254;aulast=Ghosh |
| _version_ | 1797649214930419712 |
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| author | Kaustav Ghosh Chirasree Sanyal Prakas Kumar Mandal |
| author_facet | Kaustav Ghosh Chirasree Sanyal Prakas Kumar Mandal |
| author_sort | Kaustav Ghosh |
| collection | DOAJ |
| description | Anaplastic lymphoma kinase positive (ALK+ve) large B-cell lymphoma (LBCL) is a rare, aggressive subtype of diffuse LBCL with unique morphological characteristics and unusual immunophenotypic features that have substantial overlap with other hematologic and nonhematologic neoplasms. Here, we present a 48-year-old male who presented with progressive swelling on both sides of the neck and left eye followed by protruding mass in the left nose over a span of 6 months. Based on the biopsy findings of the left nasal mass, a plasma cell neoplasm was initially diagnosed; later on the diagnosis was modified as ALK + ve LBCL based on the aggressive clinical course and biopsy findings of cervical lymph node. The patient was started on chemotherapy and is tolerating well. |
| first_indexed | 2024-03-11T15:43:02Z |
| format | Article |
| id | doaj.art-4b28a42b5cef4f26aa3f3e0658012d2f |
| institution | Directory Open Access Journal |
| issn | 1658-5127 |
| language | English |
| last_indexed | 2024-03-11T15:43:02Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Applied Hematology |
| spelling | doaj.art-4b28a42b5cef4f26aa3f3e0658012d2f2023-10-26T08:50:41ZengWolters Kluwer Medknow PublicationsJournal of Applied Hematology1658-51272023-01-0114325225410.4103/joah.joah_40_23Anaplastic lymphoma kinase positive large B-cell lymphoma mimicking as plasma cell neoplasm: A rare case reportKaustav GhoshChirasree SanyalPrakas Kumar MandalAnaplastic lymphoma kinase positive (ALK+ve) large B-cell lymphoma (LBCL) is a rare, aggressive subtype of diffuse LBCL with unique morphological characteristics and unusual immunophenotypic features that have substantial overlap with other hematologic and nonhematologic neoplasms. Here, we present a 48-year-old male who presented with progressive swelling on both sides of the neck and left eye followed by protruding mass in the left nose over a span of 6 months. Based on the biopsy findings of the left nasal mass, a plasma cell neoplasm was initially diagnosed; later on the diagnosis was modified as ALK + ve LBCL based on the aggressive clinical course and biopsy findings of cervical lymph node. The patient was started on chemotherapy and is tolerating well.http://www.jahjournal.org/article.asp?issn=1658-5127;year=2023;volume=14;issue=3;spage=252;epage=254;aulast=Ghoshanaplastic lymphoma kinase positivecervical lymph node biopsynasal massplasmacytoma |
| spellingShingle | Kaustav Ghosh Chirasree Sanyal Prakas Kumar Mandal Anaplastic lymphoma kinase positive large B-cell lymphoma mimicking as plasma cell neoplasm: A rare case report Journal of Applied Hematology anaplastic lymphoma kinase positive cervical lymph node biopsy nasal mass plasmacytoma |
| title | Anaplastic lymphoma kinase positive large B-cell lymphoma mimicking as plasma cell neoplasm: A rare case report |
| title_full | Anaplastic lymphoma kinase positive large B-cell lymphoma mimicking as plasma cell neoplasm: A rare case report |
| title_fullStr | Anaplastic lymphoma kinase positive large B-cell lymphoma mimicking as plasma cell neoplasm: A rare case report |
| title_full_unstemmed | Anaplastic lymphoma kinase positive large B-cell lymphoma mimicking as plasma cell neoplasm: A rare case report |
| title_short | Anaplastic lymphoma kinase positive large B-cell lymphoma mimicking as plasma cell neoplasm: A rare case report |
| title_sort | anaplastic lymphoma kinase positive large b cell lymphoma mimicking as plasma cell neoplasm a rare case report |
| topic | anaplastic lymphoma kinase positive cervical lymph node biopsy nasal mass plasmacytoma |
| url | http://www.jahjournal.org/article.asp?issn=1658-5127;year=2023;volume=14;issue=3;spage=252;epage=254;aulast=Ghosh |
| work_keys_str_mv | AT kaustavghosh anaplasticlymphomakinasepositivelargebcelllymphomamimickingasplasmacellneoplasmararecasereport AT chirasreesanyal anaplasticlymphomakinasepositivelargebcelllymphomamimickingasplasmacellneoplasmararecasereport AT prakaskumarmandal anaplasticlymphomakinasepositivelargebcelllymphomamimickingasplasmacellneoplasmararecasereport |