P311, Friend, or Foe of Tissue Fibrosis?
P311 was first identified by the group of Studler et al. (1993) in the developing brain. In healthy, but mainly in pathological tissues, P311 is implicated in cell migration and proliferation. Furthermore, evidence in models of tissue fibrosis points to the colocalization with and the stimulation of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.01151/full |
| _version_ | 1818160236759875584 |
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| author | Leslie Stradiot Inge Mannaerts Leo A. van Grunsven |
| author_facet | Leslie Stradiot Inge Mannaerts Leo A. van Grunsven |
| author_sort | Leslie Stradiot |
| collection | DOAJ |
| description | P311 was first identified by the group of Studler et al. (1993) in the developing brain. In healthy, but mainly in pathological tissues, P311 is implicated in cell migration and proliferation. Furthermore, evidence in models of tissue fibrosis points to the colocalization with and the stimulation of transforming growth factor β1 by P311. This review provides a comprehensive overview on P311 and discusses its potential as an anti-fibrotic target. |
| first_indexed | 2024-12-11T15:58:40Z |
| format | Article |
| id | doaj.art-4b2966d8481f4802805d22a6616f78c0 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-11T15:58:40Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-4b2966d8481f4802805d22a6616f78c02022-12-22T00:59:22ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-10-01910.3389/fphar.2018.01151416222P311, Friend, or Foe of Tissue Fibrosis?Leslie StradiotInge MannaertsLeo A. van GrunsvenP311 was first identified by the group of Studler et al. (1993) in the developing brain. In healthy, but mainly in pathological tissues, P311 is implicated in cell migration and proliferation. Furthermore, evidence in models of tissue fibrosis points to the colocalization with and the stimulation of transforming growth factor β1 by P311. This review provides a comprehensive overview on P311 and discusses its potential as an anti-fibrotic target.https://www.frontiersin.org/article/10.3389/fphar.2018.01151/fullP311fibrosisproliferationmigrationTGFβ1 |
| spellingShingle | Leslie Stradiot Inge Mannaerts Leo A. van Grunsven P311, Friend, or Foe of Tissue Fibrosis? Frontiers in Pharmacology P311 fibrosis proliferation migration TGFβ1 |
| title | P311, Friend, or Foe of Tissue Fibrosis? |
| title_full | P311, Friend, or Foe of Tissue Fibrosis? |
| title_fullStr | P311, Friend, or Foe of Tissue Fibrosis? |
| title_full_unstemmed | P311, Friend, or Foe of Tissue Fibrosis? |
| title_short | P311, Friend, or Foe of Tissue Fibrosis? |
| title_sort | p311 friend or foe of tissue fibrosis |
| topic | P311 fibrosis proliferation migration TGFβ1 |
| url | https://www.frontiersin.org/article/10.3389/fphar.2018.01151/full |
| work_keys_str_mv | AT lesliestradiot p311friendorfoeoftissuefibrosis AT ingemannaerts p311friendorfoeoftissuefibrosis AT leoavangrunsven p311friendorfoeoftissuefibrosis |