Role of SNARE Proteins in the Insertion of KCa3.1 in the Plasma Membrane of a Polarized Epithelium

Role of SNARE Proteins in the Insertion of KCa3.1 in the Plasma Membrane of a Polarized Epithelium

Targeting proteins to a specific membrane is crucial for proper epithelial cell function. KCa3.1, a calcium-activated, intermediate-conductance potassium channel, is targeted to the basolateral membrane (BLM) in epithelial cells. Surprisingly, the mechanism of KCa3.1 membrane targeting is poorly und...

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Bibliographic Details
Main Authors: Rachel E. Farquhar, Tanya T. Cheung, Matthew J. E. Logue, Fiona J. McDonald, Daniel C. Devor, Kirk L. Hamilton
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Physiology
Subjects:
K+ channels
VAMP3
SNAP-23
syntaxin-4
EBIO
clotrimazole
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.905834/full

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