Foxp3+Helios+ regulatory T cells are associated with monocyte subsets and their PD-1 expression during acute HIV-1 infection
Abstract Background Helios has been reported to stabilize regulatory T (Treg) suppressive function. Programmed cell death protein 1 (PD-1) expression in three human monocyte subsets modulates immune responses. Recently, our team reported that three monocyte subsets are associated with T helper cell...
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| Format: | Article |
| Language: | English |
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BMC
2019-10-01
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| Series: | BMC Immunology |
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| Online Access: | http://link.springer.com/article/10.1186/s12865-019-0319-7 |
| _version_ | 1818969475740860416 |
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| author | Lifeng Liu Qiuyue Zhang Peng Chen Na Guo Aixin Song Xiaojie Huang Wei Xia Li Li Christiane Moog Hao Wu Bin Su Tong Zhang |
| author_facet | Lifeng Liu Qiuyue Zhang Peng Chen Na Guo Aixin Song Xiaojie Huang Wei Xia Li Li Christiane Moog Hao Wu Bin Su Tong Zhang |
| author_sort | Lifeng Liu |
| collection | DOAJ |
| description | Abstract Background Helios has been reported to stabilize regulatory T (Treg) suppressive function. Programmed cell death protein 1 (PD-1) expression in three human monocyte subsets modulates immune responses. Recently, our team reported that three monocyte subsets are associated with T helper cell differentiation in HIV-1-infected patients. Until now, the effects of monocyte subsets and their PD-1 expression on Foxp3+Helios+ Treg cells have not been fully characterized, especially during acute HIV-1 infection. Results The frequency of Foxp3+Helios+CD45RA+ Treg cells is significantly higher in patients with acute HIV-1 infection than those of healthy controls and chronic HIV-1-infected patients undergoing combined antiretroviral therapy. The frequency of Foxp3+Helios+CD45RA+ Treg cells is inversely correlated with CD4 T-cell counts and the CD4/CD8 ratio in chronic HIV-1-infected patients. During acute HIV-1 infection, the frequency of Foxp3+Helios+CD45RA+ Treg cells is inversely correlated with the frequency of the intermediate CD14++CD16+ monocyte subset, but positively correlated with PD-1 expression in both intermediate CD14++CD16+ and non-classical CD14+CD16++ monocyte subsets. Conclusions In this study, the perturbations of Foxp3+Helios+ Treg cells were characterized, and the association between monocyte subsets and their PD-1 expression and Foxp3+Helios+ Treg cells was evaluated during HIV-1 infection. Our observations provide new evidence of the roles for Foxp3+Helios+ Treg cells and PD-1 expression on monocyte subsets in HIV pathogenesis. |
| first_indexed | 2024-12-20T14:21:11Z |
| format | Article |
| id | doaj.art-4b2c6b80cabe41698f23dce9f1c4f5bd |
| institution | Directory Open Access Journal |
| issn | 1471-2172 |
| language | English |
| last_indexed | 2024-12-20T14:21:11Z |
| publishDate | 2019-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj.art-4b2c6b80cabe41698f23dce9f1c4f5bd2022-12-21T19:37:55ZengBMCBMC Immunology1471-21722019-10-012011810.1186/s12865-019-0319-7Foxp3+Helios+ regulatory T cells are associated with monocyte subsets and their PD-1 expression during acute HIV-1 infectionLifeng Liu0Qiuyue Zhang1Peng Chen2Na Guo3Aixin Song4Xiaojie Huang5Wei Xia6Li Li7Christiane Moog8Hao Wu9Bin Su10Tong Zhang11Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical UniversityINSERM U1109, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de StrasbourgCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical UniversityCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical UniversityAbstract Background Helios has been reported to stabilize regulatory T (Treg) suppressive function. Programmed cell death protein 1 (PD-1) expression in three human monocyte subsets modulates immune responses. Recently, our team reported that three monocyte subsets are associated with T helper cell differentiation in HIV-1-infected patients. Until now, the effects of monocyte subsets and their PD-1 expression on Foxp3+Helios+ Treg cells have not been fully characterized, especially during acute HIV-1 infection. Results The frequency of Foxp3+Helios+CD45RA+ Treg cells is significantly higher in patients with acute HIV-1 infection than those of healthy controls and chronic HIV-1-infected patients undergoing combined antiretroviral therapy. The frequency of Foxp3+Helios+CD45RA+ Treg cells is inversely correlated with CD4 T-cell counts and the CD4/CD8 ratio in chronic HIV-1-infected patients. During acute HIV-1 infection, the frequency of Foxp3+Helios+CD45RA+ Treg cells is inversely correlated with the frequency of the intermediate CD14++CD16+ monocyte subset, but positively correlated with PD-1 expression in both intermediate CD14++CD16+ and non-classical CD14+CD16++ monocyte subsets. Conclusions In this study, the perturbations of Foxp3+Helios+ Treg cells were characterized, and the association between monocyte subsets and their PD-1 expression and Foxp3+Helios+ Treg cells was evaluated during HIV-1 infection. Our observations provide new evidence of the roles for Foxp3+Helios+ Treg cells and PD-1 expression on monocyte subsets in HIV pathogenesis.http://link.springer.com/article/10.1186/s12865-019-0319-7Foxp3+Helios+Monocyte subsetsPD-1Acute HIV-1 infection |
| spellingShingle | Lifeng Liu Qiuyue Zhang Peng Chen Na Guo Aixin Song Xiaojie Huang Wei Xia Li Li Christiane Moog Hao Wu Bin Su Tong Zhang Foxp3+Helios+ regulatory T cells are associated with monocyte subsets and their PD-1 expression during acute HIV-1 infection BMC Immunology Foxp3+Helios+ Monocyte subsets PD-1 Acute HIV-1 infection |
| title | Foxp3+Helios+ regulatory T cells are associated with monocyte subsets and their PD-1 expression during acute HIV-1 infection |
| title_full | Foxp3+Helios+ regulatory T cells are associated with monocyte subsets and their PD-1 expression during acute HIV-1 infection |
| title_fullStr | Foxp3+Helios+ regulatory T cells are associated with monocyte subsets and their PD-1 expression during acute HIV-1 infection |
| title_full_unstemmed | Foxp3+Helios+ regulatory T cells are associated with monocyte subsets and their PD-1 expression during acute HIV-1 infection |
| title_short | Foxp3+Helios+ regulatory T cells are associated with monocyte subsets and their PD-1 expression during acute HIV-1 infection |
| title_sort | foxp3 helios regulatory t cells are associated with monocyte subsets and their pd 1 expression during acute hiv 1 infection |
| topic | Foxp3+Helios+ Monocyte subsets PD-1 Acute HIV-1 infection |
| url | http://link.springer.com/article/10.1186/s12865-019-0319-7 |
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