Metabolic Bypass Rescues Aberrant S‐nitrosylation‐Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons

Metabolic Bypass Rescues Aberrant S‐nitrosylation‐Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons

Abstract In Alzheimer's disease (AD), dysfunctional mitochondrial metabolism is associated with synaptic loss, the major pathological correlate of cognitive decline. Mechanistic insight for this relationship, however, is still lacking. Here, comparing isogenic wild‐type and AD mutant human indu...

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Bibliographic Details
Main Authors: Alexander Y. Andreyev, Hongmei Yang, Paschalis‐Thomas Doulias, Nima Dolatabadi, Xu Zhang, Melissa Luevanos, Mayra Blanco, Christine Baal, Ivan Putra, Tomohiro Nakamura, Harry Ischiropoulos, Steven R. Tannenbaum, Stuart A. Lipton
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Advanced Science
Subjects:
Alzheimer's diseases
S‐nitrosylation
tricarboxylic acid cycles
Online Access:https://doi.org/10.1002/advs.202306469

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