Is it necessary for young patients with recurrent implantation failure to undergo preimplantation genetic testing for aneuploidy?
ObjectiveTo determine whether preimplantation genetic testing for aneuploidy (PGT-A) can improve the pregnancy outcomes of patients aged under 38 years who have a history of recurrent implantation failure(RIF).DesignRetrospective cohort study.MethodsWe retrospectively studied the pregnancy outcomes...
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| Format: | Article |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1020055/full |
| _version_ | 1797937317200003072 |
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| author | Yulin Du Yichun Guan Na Li Congxing Shi Yongjie Zhang Bingnan Ren Jing Liu Hua Lou |
| author_facet | Yulin Du Yichun Guan Na Li Congxing Shi Yongjie Zhang Bingnan Ren Jing Liu Hua Lou |
| author_sort | Yulin Du |
| collection | DOAJ |
| description | ObjectiveTo determine whether preimplantation genetic testing for aneuploidy (PGT-A) can improve the pregnancy outcomes of patients aged under 38 years who have a history of recurrent implantation failure(RIF).DesignRetrospective cohort study.MethodsWe retrospectively studied the pregnancy outcomes of RIF patients aged under 38 years from January 2017 to December 2021.178 patients were divided into two groups according to whether they underwent PGT-A: the PGT-A group(n=59)and the control group(n=119).In the PGT-A group, we compared the euploidy rate of the different quality and developmental rate blastocysts. In both groups,the patients were the first frozen-thaw single blastocysts transfer after the diagnosis of RIF. Among the pregnancy outcomes, the clinical pregnancy rate was assessed as the primary outcome. The spontaneous abortion rate and ongoing pregnancy rate were the secondry outcomes. The generalized estimation equation was used to adjust for the blastocysts derived from the same patients. Multivariate logistic analysis models were used to compare the pregnancy outcomes between the two groups.ResultsIn the PGT-A group, 293 blastocysts obtained from59 patients underwent PGT-A. The proportions of euploidy, aneuploidy and mosaic blastocysts were 56.31%, 25.60% and 18.09%, respectively. A comparison of the euploidy rates of different quality blastocysts showed that the rate of good-quality blastocysts was significantly higher than that of poor-quality blastocysts (67.66% vs 46.88%; odds ratio [OR], 2.203; 95%confidence interval[CI], 0.943–3.612; P=0.002). However, no significant difference was observed in the different developmental rates blastocysts. Compared with Day 5 blastocysts, the euploidy rates of Day 6 and Day 7 blastocysts were not significantly different(61.54%vs51.91%; OR,0.945; 95%CI, 0.445–2.010; P=0.884; and 61.54%vs47.37%; OR, 1.106; 95%CI, 0.774–1.578; P=0.581, respectively).As for the pregnancy outcomes, the clinical pregnancy rate was significantly increase after the use of PGT-A compared with the control group(71.19%vs56.30%; OR, 0.538; 95%CI, 0.262–1.104; P=0.039). However, the spontaneous abortion rates and ongoing pregnancy rates were not significantly different between the control and PGT-A groups (21.43% vs 19.40%; aOR,0.727; 95%CI,0.271–1.945; P=0.525; and55.93% vs 45.38%; aOR, 0.649; 95%CI, 0.329–1.283; P = 0.214,respectively).ConclusionPGT-A improved the clinical pregnancy rate after blastocyst transfer in RIF patients aged under 38 years. |
| first_indexed | 2024-04-10T18:42:42Z |
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| language | English |
| last_indexed | 2024-04-10T18:42:42Z |
| publishDate | 2023-02-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-4b2e7be747194b4a8866dbe21a9733882023-02-01T12:01:44ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-02-011410.3389/fendo.2023.10200551020055Is it necessary for young patients with recurrent implantation failure to undergo preimplantation genetic testing for aneuploidy?Yulin Du0Yichun Guan1Na Li2Congxing Shi3Yongjie Zhang4Bingnan Ren5Jing Liu6Hua Lou7Reproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaReproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaReproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaSchool of Public Health, Sun Yat-sen University, Guangzhou, ChinaReproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaReproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaReproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaReproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaObjectiveTo determine whether preimplantation genetic testing for aneuploidy (PGT-A) can improve the pregnancy outcomes of patients aged under 38 years who have a history of recurrent implantation failure(RIF).DesignRetrospective cohort study.MethodsWe retrospectively studied the pregnancy outcomes of RIF patients aged under 38 years from January 2017 to December 2021.178 patients were divided into two groups according to whether they underwent PGT-A: the PGT-A group(n=59)and the control group(n=119).In the PGT-A group, we compared the euploidy rate of the different quality and developmental rate blastocysts. In both groups,the patients were the first frozen-thaw single blastocysts transfer after the diagnosis of RIF. Among the pregnancy outcomes, the clinical pregnancy rate was assessed as the primary outcome. The spontaneous abortion rate and ongoing pregnancy rate were the secondry outcomes. The generalized estimation equation was used to adjust for the blastocysts derived from the same patients. Multivariate logistic analysis models were used to compare the pregnancy outcomes between the two groups.ResultsIn the PGT-A group, 293 blastocysts obtained from59 patients underwent PGT-A. The proportions of euploidy, aneuploidy and mosaic blastocysts were 56.31%, 25.60% and 18.09%, respectively. A comparison of the euploidy rates of different quality blastocysts showed that the rate of good-quality blastocysts was significantly higher than that of poor-quality blastocysts (67.66% vs 46.88%; odds ratio [OR], 2.203; 95%confidence interval[CI], 0.943–3.612; P=0.002). However, no significant difference was observed in the different developmental rates blastocysts. Compared with Day 5 blastocysts, the euploidy rates of Day 6 and Day 7 blastocysts were not significantly different(61.54%vs51.91%; OR,0.945; 95%CI, 0.445–2.010; P=0.884; and 61.54%vs47.37%; OR, 1.106; 95%CI, 0.774–1.578; P=0.581, respectively).As for the pregnancy outcomes, the clinical pregnancy rate was significantly increase after the use of PGT-A compared with the control group(71.19%vs56.30%; OR, 0.538; 95%CI, 0.262–1.104; P=0.039). However, the spontaneous abortion rates and ongoing pregnancy rates were not significantly different between the control and PGT-A groups (21.43% vs 19.40%; aOR,0.727; 95%CI,0.271–1.945; P=0.525; and55.93% vs 45.38%; aOR, 0.649; 95%CI, 0.329–1.283; P = 0.214,respectively).ConclusionPGT-A improved the clinical pregnancy rate after blastocyst transfer in RIF patients aged under 38 years.https://www.frontiersin.org/articles/10.3389/fendo.2023.1020055/fullrecurrent implantation failurepreimplantation genetic testing for aneuploidyblastocystfrozen embryo transferpregnancy outcomes |
| spellingShingle | Yulin Du Yichun Guan Na Li Congxing Shi Yongjie Zhang Bingnan Ren Jing Liu Hua Lou Is it necessary for young patients with recurrent implantation failure to undergo preimplantation genetic testing for aneuploidy? Frontiers in Endocrinology recurrent implantation failure preimplantation genetic testing for aneuploidy blastocyst frozen embryo transfer pregnancy outcomes |
| title | Is it necessary for young patients with recurrent implantation failure to undergo preimplantation genetic testing for aneuploidy? |
| title_full | Is it necessary for young patients with recurrent implantation failure to undergo preimplantation genetic testing for aneuploidy? |
| title_fullStr | Is it necessary for young patients with recurrent implantation failure to undergo preimplantation genetic testing for aneuploidy? |
| title_full_unstemmed | Is it necessary for young patients with recurrent implantation failure to undergo preimplantation genetic testing for aneuploidy? |
| title_short | Is it necessary for young patients with recurrent implantation failure to undergo preimplantation genetic testing for aneuploidy? |
| title_sort | is it necessary for young patients with recurrent implantation failure to undergo preimplantation genetic testing for aneuploidy |
| topic | recurrent implantation failure preimplantation genetic testing for aneuploidy blastocyst frozen embryo transfer pregnancy outcomes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1020055/full |
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