Thromboembolic events in patients with inflammatory bowel disease
Background/Aims: Inflammatory bowel disease (ulcerative colitis and Crohn's disease) is characterized by a chronic inflammatory condition, and is accompanied by abnormalities in coagulation and a hyper-coagulable state. This study was conducted to examine the risk factors for developing Thrombo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2016;volume=22;issue=6;spage=423;epage=427;aulast=Algahtani |
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| author | Farjah H Algahtani Youssef M.K Farag Abdulrahman M Aljebreen Nahla A Alazzam Aamer S Aleem Fouad F Jabri Mohammad H Rajab Mohamed M Shoukri |
| author_facet | Farjah H Algahtani Youssef M.K Farag Abdulrahman M Aljebreen Nahla A Alazzam Aamer S Aleem Fouad F Jabri Mohammad H Rajab Mohamed M Shoukri |
| author_sort | Farjah H Algahtani |
| collection | DOAJ |
| description | Background/Aims: Inflammatory bowel disease (ulcerative colitis and Crohn's disease) is characterized by a chronic inflammatory condition, and is accompanied by abnormalities in coagulation and a hyper-coagulable state. This study was conducted to examine the risk factors for developing Thromboembolic Events in Inflammatory Bowel Disease (IBD) in a population with prevalent consanguinity. Patients and Methods: Patients with a definitive diagnosis of IBD who were seen in the gastroenterology clinic of King Khalid University Hospital (Riyadh, Saudi Arabia) from 2010- to 2012, were asked to participate in this prospective cohort study, and were followed for one 1 year. Data was collected using specifically designed case report forms (CRF) by trained research personnel. Results: A total of 100 Saudi patients with IBD were studied. There were 51 (51%) women and the mean ± standard deviation (SD) age of the group was 31.24 ± 10.78 years. Those with Crohn's disease constituted 72% of the patients, and 28% had ulcerative colitis. Eight patients (8%) had at least one Thrombotic Event ([six deep venous thrombosis (DVT), and two pulmonary embolism (PE)]. Family history of deep venous thrombosis was present in 5%, and family history of pulmonary embolism (PE) in 4% of the patients. After adjusting for age and gender, a family history of Thrombotic event was identified as to be the only statistically significant predictor of thrombosis in IBD patients (RR = 9.22, 95% CI: 2.10-–40.43). Conclusion: In a population with high consanguinity, Thromboembolic events (DVT and PE) had a prevalence of 8% among IBD patients, positive family history of pulmonary embolism was a predictor of thrombosis. Further studies are needed to explore the role of genetic factors in this population. |
| first_indexed | 2024-04-11T23:14:07Z |
| format | Article |
| id | doaj.art-4b2fadb3a21f4bdbb65837ca497e2310 |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-04-11T23:14:07Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-4b2fadb3a21f4bdbb65837ca497e23102022-12-22T03:57:40ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492016-01-0122642342710.4103/1319-3767.195558Thromboembolic events in patients with inflammatory bowel diseaseFarjah H AlgahtaniYoussef M.K FaragAbdulrahman M AljebreenNahla A AlazzamAamer S AleemFouad F JabriMohammad H RajabMohamed M ShoukriBackground/Aims: Inflammatory bowel disease (ulcerative colitis and Crohn's disease) is characterized by a chronic inflammatory condition, and is accompanied by abnormalities in coagulation and a hyper-coagulable state. This study was conducted to examine the risk factors for developing Thromboembolic Events in Inflammatory Bowel Disease (IBD) in a population with prevalent consanguinity. Patients and Methods: Patients with a definitive diagnosis of IBD who were seen in the gastroenterology clinic of King Khalid University Hospital (Riyadh, Saudi Arabia) from 2010- to 2012, were asked to participate in this prospective cohort study, and were followed for one 1 year. Data was collected using specifically designed case report forms (CRF) by trained research personnel. Results: A total of 100 Saudi patients with IBD were studied. There were 51 (51%) women and the mean ± standard deviation (SD) age of the group was 31.24 ± 10.78 years. Those with Crohn's disease constituted 72% of the patients, and 28% had ulcerative colitis. Eight patients (8%) had at least one Thrombotic Event ([six deep venous thrombosis (DVT), and two pulmonary embolism (PE)]. Family history of deep venous thrombosis was present in 5%, and family history of pulmonary embolism (PE) in 4% of the patients. After adjusting for age and gender, a family history of Thrombotic event was identified as to be the only statistically significant predictor of thrombosis in IBD patients (RR = 9.22, 95% CI: 2.10-–40.43). Conclusion: In a population with high consanguinity, Thromboembolic events (DVT and PE) had a prevalence of 8% among IBD patients, positive family history of pulmonary embolism was a predictor of thrombosis. Further studies are needed to explore the role of genetic factors in this population.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2016;volume=22;issue=6;spage=423;epage=427;aulast=AlgahtaniDeep vein thrombosisinflammatory bowel diseasepulmonary embolismthromboembolismthrombosisthrombosisvenous thromboembolism |
| spellingShingle | Farjah H Algahtani Youssef M.K Farag Abdulrahman M Aljebreen Nahla A Alazzam Aamer S Aleem Fouad F Jabri Mohammad H Rajab Mohamed M Shoukri Thromboembolic events in patients with inflammatory bowel disease The Saudi Journal of Gastroenterology Deep vein thrombosis inflammatory bowel disease pulmonary embolism thromboembolism thrombosis thrombosis venous thromboembolism |
| title | Thromboembolic events in patients with inflammatory bowel disease |
| title_full | Thromboembolic events in patients with inflammatory bowel disease |
| title_fullStr | Thromboembolic events in patients with inflammatory bowel disease |
| title_full_unstemmed | Thromboembolic events in patients with inflammatory bowel disease |
| title_short | Thromboembolic events in patients with inflammatory bowel disease |
| title_sort | thromboembolic events in patients with inflammatory bowel disease |
| topic | Deep vein thrombosis inflammatory bowel disease pulmonary embolism thromboembolism thrombosis thrombosis venous thromboembolism |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2016;volume=22;issue=6;spage=423;epage=427;aulast=Algahtani |
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