Comparative Evaluation of Ciprofloxacin Levels in GCF and Plasma of Chronic Periodontitis Patients: Quasi Experimental Study
Introduction: For any antimicrobial approach to be successful in periodontal therapy, it is important that the antimicrobial agent targets the sub-gingival biofilm by attaining sufficient concentration at the sub-gingival site. Aim: The purpose of the present study was to determine and compare...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7987/18446_CE(EK)_F(AK)_PF1(EKAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: For any antimicrobial approach to be successful
in periodontal therapy, it is important that the antimicrobial
agent targets the sub-gingival biofilm by attaining sufficient
concentration at the sub-gingival site.
Aim: The purpose of the present study was to determine
and compare the concentrations of ciprofloxacin present in
Gingival Crevicular Fluid (GCF) and plasma after its systemic
administration.
Materials and Methods: A total of 20 subjects, in the age group
of 30-60 years satisfying the inclusion and exclusion criteria,
were chosen from the outpatient Department of Periodontology,
Government Dental College and Hospital, Hyderabad and
consent was obtained. Subjects were put on oral ciprofloxacin
therapy (Baycip, Bayer Corporation) of 500mg twice daily
doses for five days to establish steady state tissue levels of the
agent. GCF and serum samples were collected at the 72nd hour
after the first dose of ciprofloxacin and were compared using
unpaired t test.
Results: The mean gingival index value of the subjects was 1.8
± 0.59 and the mean probing depth of the subjects taken in the
study was 5.724 ± 0.47mm. The results of this study showed
that ciprofloxacin concentrations were significantly higher
(p<0.001) in GCF than in plasma.
Conclusion: Results from the present study and those from
the earlier studies clearly indicate the ciprofloxacin’s ability to
reach and concentrate in infected periodontal sites via GCF.
This property of ciprofloxacin may be useful for eradication
of periodontal pathogens, thus improving the outcome of
periodontal therapy. |
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| ISSN: | 2249-782X 0973-709X |