Research advances in cGAS–stimulator of interferon genes pathway and central nervous system diseases: Focus on new therapeutic approaches

Research advances in cGAS–stimulator of interferon genes pathway and central nervous system diseases: Focus on new therapeutic approaches

Cyclic GMP–AMP synthase (cGAS), a crucial innate immune sensor, recognizes cytosolic DNA and induces stimulator of interferon genes (STING) to produce type I interferon and other proinflammatory cytokines, thereby mediating innate immune signaling. The cGAS–STING pathway is involved in the regulatio...

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Bibliographic Details
Main Authors: Jiao Ding, Yijie Dai, Jiahui Zhu, Xuemei Fan, Hao Zhang, Bo Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cGAS
cGAMP
STING
innate immune system
autophagy
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1050837/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.1050837/full

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