Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH
<p>Abstract</p> <p>Background</p> <p>The ideal medication for acid-related diseases should have a rapid onset of action to promote hemostasis and cause efficient resolution of symptoms. The aim of our study was to comparatively investigate the inhibitory effect on gastr...
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BMC
2012-03-01
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| Series: | BMC Gastroenterology |
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| Online Access: | http://www.biomedcentral.com/1471-230X/12/25 |
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| author | Iida Hiroshi Inamori Masahiko Fujii Tetsuro Sekino Yusuke Endo Hiroki Hosono Kunihiro Nonaka Takashi Koide Tomoko Takahashi Hirokazu Yoneda Masato Goto Ayumu Abe Yasunobu Kobayashi Noritoshi Kirikoshi Hiroyuki Kubota Kensuke Saito Satoru Gotoh Eiji Maeda Shin Nakajima Atsushi |
| author_facet | Iida Hiroshi Inamori Masahiko Fujii Tetsuro Sekino Yusuke Endo Hiroki Hosono Kunihiro Nonaka Takashi Koide Tomoko Takahashi Hirokazu Yoneda Masato Goto Ayumu Abe Yasunobu Kobayashi Noritoshi Kirikoshi Hiroyuki Kubota Kensuke Saito Satoru Gotoh Eiji Maeda Shin Nakajima Atsushi |
| author_sort | Iida Hiroshi |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The ideal medication for acid-related diseases should have a rapid onset of action to promote hemostasis and cause efficient resolution of symptoms. The aim of our study was to comparatively investigate the inhibitory effect on gastric acid secretion of a single oral administration of omeprazole plus mosapride with that of omeprazole alone.</p> <p>Methods</p> <p>Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 hours after a single oral administration of omeprazole 20 mg or that of omeprazole 20 mg plus mosapride 5 mg (the omeprazole being administered one hour after the mosapride). Each administration was separated by a 7-days washout period.</p> <p>Results</p> <p>The average pH during the 6-hour period after administration of omeprazole 20 mg plus mosapride 5 mg was higher than that after administration of omeprazole 20 mg alone (median: 3.22 versus 4.21, respectively; <it>p </it>= 0.0247).</p> <p>Conclusions</p> <p>In H. pylori -negative healthy male subjects, an oral dose of omeprazole 20 mg plus mosapride 5 mg increased the intragastric pH more rapidly than omeprazole 20 mg alone.</p> |
| first_indexed | 2024-12-12T21:22:51Z |
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| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-12T21:22:51Z |
| publishDate | 2012-03-01 |
| publisher | BMC |
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| series | BMC Gastroenterology |
| spelling | doaj.art-4b325d23eff545ad98c1834196525deb2022-12-22T00:11:31ZengBMCBMC Gastroenterology1471-230X2012-03-011212510.1186/1471-230X-12-25Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pHIida HiroshiInamori MasahikoFujii TetsuroSekino YusukeEndo HirokiHosono KunihiroNonaka TakashiKoide TomokoTakahashi HirokazuYoneda MasatoGoto AyumuAbe YasunobuKobayashi NoritoshiKirikoshi HiroyukiKubota KensukeSaito SatoruGotoh EijiMaeda ShinNakajima Atsushi<p>Abstract</p> <p>Background</p> <p>The ideal medication for acid-related diseases should have a rapid onset of action to promote hemostasis and cause efficient resolution of symptoms. The aim of our study was to comparatively investigate the inhibitory effect on gastric acid secretion of a single oral administration of omeprazole plus mosapride with that of omeprazole alone.</p> <p>Methods</p> <p>Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 hours after a single oral administration of omeprazole 20 mg or that of omeprazole 20 mg plus mosapride 5 mg (the omeprazole being administered one hour after the mosapride). Each administration was separated by a 7-days washout period.</p> <p>Results</p> <p>The average pH during the 6-hour period after administration of omeprazole 20 mg plus mosapride 5 mg was higher than that after administration of omeprazole 20 mg alone (median: 3.22 versus 4.21, respectively; <it>p </it>= 0.0247).</p> <p>Conclusions</p> <p>In H. pylori -negative healthy male subjects, an oral dose of omeprazole 20 mg plus mosapride 5 mg increased the intragastric pH more rapidly than omeprazole 20 mg alone.</p>http://www.biomedcentral.com/1471-230X/12/25Intragastric acidityOmeprazoleMosapride |
| spellingShingle | Iida Hiroshi Inamori Masahiko Fujii Tetsuro Sekino Yusuke Endo Hiroki Hosono Kunihiro Nonaka Takashi Koide Tomoko Takahashi Hirokazu Yoneda Masato Goto Ayumu Abe Yasunobu Kobayashi Noritoshi Kirikoshi Hiroyuki Kubota Kensuke Saito Satoru Gotoh Eiji Maeda Shin Nakajima Atsushi Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH BMC Gastroenterology Intragastric acidity Omeprazole Mosapride |
| title | Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH |
| title_full | Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH |
| title_fullStr | Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH |
| title_full_unstemmed | Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH |
| title_short | Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH |
| title_sort | early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric ph |
| topic | Intragastric acidity Omeprazole Mosapride |
| url | http://www.biomedcentral.com/1471-230X/12/25 |
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