Exosomes: potential diagnostic markers and drug carriers for adenomyosis
Adenomyosis is a common benign gynecological disorder and an important factor leading to infertility in fertile women. Adenomyosis can cause deep lesions and is persistent and refractory in nature due to its tumor-like biological characteristics, such as the ability to implant, adhere, and invade. T...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1216149/full |
| _version_ | 1797738247769554944 |
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| author | Wen-Xiu Cheng Shao-Bin Wei Yang Zhou Yu Shao Mao-Ya Li |
| author_facet | Wen-Xiu Cheng Shao-Bin Wei Yang Zhou Yu Shao Mao-Ya Li |
| author_sort | Wen-Xiu Cheng |
| collection | DOAJ |
| description | Adenomyosis is a common benign gynecological disorder and an important factor leading to infertility in fertile women. Adenomyosis can cause deep lesions and is persistent and refractory in nature due to its tumor-like biological characteristics, such as the ability to implant, adhere, and invade. The pathogenesis of adenomyosis is currently unclear. Therefore, new therapeutic approaches are urgently required. Exosomes are nanoscale vesicles secreted by cells that carry proteins, genetic materials and other biologically active components. Exosomes play an important role in maintaining tissue homeostasis and regulating immune responses and metabolism. A growing body of work has shown that exosomes and their contents are key to the development and progression of adenomyosis. This review discusses the current research progress, future prospects and challenges in this emerging therapeutic tool by providing an overview of the changes in the adenomyosis uterine microenvironment and the biogenesis and functions of exosomes, with particular emphasis on the role of exosomes and their contents in the regulation of cell migration, proliferation, fibrosis formation, neovascularization, and inflammatory responses in adenomyosis. |
| first_indexed | 2024-03-12T13:40:04Z |
| format | Article |
| id | doaj.art-4b33844cdc4141a6a5e935653c8f6b89 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-12T13:40:04Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-4b33844cdc4141a6a5e935653c8f6b892023-08-23T19:25:55ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-08-011410.3389/fphar.2023.12161491216149Exosomes: potential diagnostic markers and drug carriers for adenomyosisWen-Xiu Cheng0Shao-Bin Wei1Yang Zhou2Yu Shao3Mao-Ya Li4Department of Gynecology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaDepartment of Gynecology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaTrauma Center, Rizhao Hospital of Traditional Chinese Medicine, Rizhao, Shandong, ChinaDepartment of Gynecology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaDepartment of Gynecology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaAdenomyosis is a common benign gynecological disorder and an important factor leading to infertility in fertile women. Adenomyosis can cause deep lesions and is persistent and refractory in nature due to its tumor-like biological characteristics, such as the ability to implant, adhere, and invade. The pathogenesis of adenomyosis is currently unclear. Therefore, new therapeutic approaches are urgently required. Exosomes are nanoscale vesicles secreted by cells that carry proteins, genetic materials and other biologically active components. Exosomes play an important role in maintaining tissue homeostasis and regulating immune responses and metabolism. A growing body of work has shown that exosomes and their contents are key to the development and progression of adenomyosis. This review discusses the current research progress, future prospects and challenges in this emerging therapeutic tool by providing an overview of the changes in the adenomyosis uterine microenvironment and the biogenesis and functions of exosomes, with particular emphasis on the role of exosomes and their contents in the regulation of cell migration, proliferation, fibrosis formation, neovascularization, and inflammatory responses in adenomyosis.https://www.frontiersin.org/articles/10.3389/fphar.2023.1216149/fulladenomyosispathogenesisexosomescell proliferationfibrosis formation |
| spellingShingle | Wen-Xiu Cheng Shao-Bin Wei Yang Zhou Yu Shao Mao-Ya Li Exosomes: potential diagnostic markers and drug carriers for adenomyosis Frontiers in Pharmacology adenomyosis pathogenesis exosomes cell proliferation fibrosis formation |
| title | Exosomes: potential diagnostic markers and drug carriers for adenomyosis |
| title_full | Exosomes: potential diagnostic markers and drug carriers for adenomyosis |
| title_fullStr | Exosomes: potential diagnostic markers and drug carriers for adenomyosis |
| title_full_unstemmed | Exosomes: potential diagnostic markers and drug carriers for adenomyosis |
| title_short | Exosomes: potential diagnostic markers and drug carriers for adenomyosis |
| title_sort | exosomes potential diagnostic markers and drug carriers for adenomyosis |
| topic | adenomyosis pathogenesis exosomes cell proliferation fibrosis formation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1216149/full |
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