Frailty syndrome and associated factors among patients with hypertension: A cross‐sectional study in Kumasi, Ghana
Abstract Background and Aim Frailty is a condition marked by accumulation of biological deficits and dysfunctions that come with aging and it is correlated with high morbidity and mortality in patients with cardiovascular diseases, particularly hypertension. Hypertension continues to be a leading ca...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-10-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.1664 |
| _version_ | 1797310516494860288 |
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| author | Samuel A. Sakyi Phyllis Tawiah Ebenezer Senu Ransford O. Ampofo Anthony K. Enimil Benjamin Amoani Enoch O. Anto Stephen Opoku Alfred Effah Elizabeth Abban Joseph Frimpong Emmaunel Frimpong Lydia Oppong Bannor Afia A. Kwayie Emmanuel Naturinda Eugene A. Ansah Bright T. Baidoo Kini E. Kodzo Nana K. Ayisi‐Boateng |
| author_facet | Samuel A. Sakyi Phyllis Tawiah Ebenezer Senu Ransford O. Ampofo Anthony K. Enimil Benjamin Amoani Enoch O. Anto Stephen Opoku Alfred Effah Elizabeth Abban Joseph Frimpong Emmaunel Frimpong Lydia Oppong Bannor Afia A. Kwayie Emmanuel Naturinda Eugene A. Ansah Bright T. Baidoo Kini E. Kodzo Nana K. Ayisi‐Boateng |
| author_sort | Samuel A. Sakyi |
| collection | DOAJ |
| description | Abstract Background and Aim Frailty is a condition marked by accumulation of biological deficits and dysfunctions that come with aging and it is correlated with high morbidity and mortality in patients with cardiovascular diseases, particularly hypertension. Hypertension continues to be a leading cause of cardiovascular diseases and premature death globally. However, there is dearth of literature in sub‐Saharan Africa on frailty syndrome among hypertensives on medication. This study evaluated frailty syndrome and its associated factors among Ghanaian hypertensives. Methods This cross‐sectional study recruited 303 patients with hypertension from the University Hospital, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana. Data on sociodemographic, lifestyle and clinical factors were collected using a well‐structured questionnaire. Medication adherence was measured using Adherence in Chronic Disease Scale, and frailty was assessed by Tilburg Frailty Indicator. Statistical analyses were performed using SPSS Version 26.0 and GraphPad prism 8.0. p‐value of < 0.05 and 95% confidence interval (CI) were considered statistically significant. Results The prevalence of frailty was 59.7%. The proportion of high, medium and low medication adherence was 23.4%, 64.4% and 12.2%, respectively. Being ≥ 70years (adjusted odds ratio [aOR]: 8.33, 95% CI [3.72–18.67], p < 0.0001), unmarried (aOR: 2.59, 95% CI [1.37–4.89], p = 0.0030), having confirmed hypertension complications (aOR: 3.21, 95% CI [1.36–7.53], p = 0.0080), medium (aOR: 1.99, 95% CI [1.05–3.82], p = 0.0360) and low antihypertensive drug adherence (aOR: 27.69, 95% CI [7.05–108.69], p < 0.0001) were independent predictors of increased odds of developing frailty syndrome. Conclusion Approximately 6 out of 10 Ghanaian adult patients with hypertension experience frailty syndrome. Hypertension complications, older age, being unmarried, and low antihypertensive drug adherence increased the chances of developing frailty syndrome. These should be considered in intervention programmes to prevent frailty among patients with hypertension. |
| first_indexed | 2024-03-08T01:45:07Z |
| format | Article |
| id | doaj.art-4b36389b7b3a443b993c95f49b36e9a7 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-08T01:45:07Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-4b36389b7b3a443b993c95f49b36e9a72024-02-14T13:06:23ZengWileyHealth Science Reports2398-88352023-10-01610n/an/a10.1002/hsr2.1664Frailty syndrome and associated factors among patients with hypertension: A cross‐sectional study in Kumasi, GhanaSamuel A. Sakyi0Phyllis Tawiah1Ebenezer Senu2Ransford O. Ampofo3Anthony K. Enimil4Benjamin Amoani5Enoch O. Anto6Stephen Opoku7Alfred Effah8Elizabeth Abban9Joseph Frimpong10Emmaunel Frimpong11Lydia Oppong Bannor12Afia A. Kwayie13Emmanuel Naturinda14Eugene A. Ansah15Bright T. Baidoo16Kini E. Kodzo17Nana K. Ayisi‐Boateng18Department of Molecular Medicine Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medicine, School of Medicine and Dentistry Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Molecular Medicine Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaPediatric Infectious Disease Unit, Child Health Directorate Komfo Anokye Teaching Hospital Kumasi GhanaDepartment of Biomedical Science University of Cape Coast Cape Coast GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Molecular Medicine Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Molecular Medicine Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medicine, School of Medicine and Dentistry Kwame Nkrumah University of Science and Technology Kumasi GhanaAbstract Background and Aim Frailty is a condition marked by accumulation of biological deficits and dysfunctions that come with aging and it is correlated with high morbidity and mortality in patients with cardiovascular diseases, particularly hypertension. Hypertension continues to be a leading cause of cardiovascular diseases and premature death globally. However, there is dearth of literature in sub‐Saharan Africa on frailty syndrome among hypertensives on medication. This study evaluated frailty syndrome and its associated factors among Ghanaian hypertensives. Methods This cross‐sectional study recruited 303 patients with hypertension from the University Hospital, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana. Data on sociodemographic, lifestyle and clinical factors were collected using a well‐structured questionnaire. Medication adherence was measured using Adherence in Chronic Disease Scale, and frailty was assessed by Tilburg Frailty Indicator. Statistical analyses were performed using SPSS Version 26.0 and GraphPad prism 8.0. p‐value of < 0.05 and 95% confidence interval (CI) were considered statistically significant. Results The prevalence of frailty was 59.7%. The proportion of high, medium and low medication adherence was 23.4%, 64.4% and 12.2%, respectively. Being ≥ 70years (adjusted odds ratio [aOR]: 8.33, 95% CI [3.72–18.67], p < 0.0001), unmarried (aOR: 2.59, 95% CI [1.37–4.89], p = 0.0030), having confirmed hypertension complications (aOR: 3.21, 95% CI [1.36–7.53], p = 0.0080), medium (aOR: 1.99, 95% CI [1.05–3.82], p = 0.0360) and low antihypertensive drug adherence (aOR: 27.69, 95% CI [7.05–108.69], p < 0.0001) were independent predictors of increased odds of developing frailty syndrome. Conclusion Approximately 6 out of 10 Ghanaian adult patients with hypertension experience frailty syndrome. Hypertension complications, older age, being unmarried, and low antihypertensive drug adherence increased the chances of developing frailty syndrome. These should be considered in intervention programmes to prevent frailty among patients with hypertension.https://doi.org/10.1002/hsr2.1664antihypertensivesfrailty syndromehigh blood pressurehypertensionmedication adherence |
| spellingShingle | Samuel A. Sakyi Phyllis Tawiah Ebenezer Senu Ransford O. Ampofo Anthony K. Enimil Benjamin Amoani Enoch O. Anto Stephen Opoku Alfred Effah Elizabeth Abban Joseph Frimpong Emmaunel Frimpong Lydia Oppong Bannor Afia A. Kwayie Emmanuel Naturinda Eugene A. Ansah Bright T. Baidoo Kini E. Kodzo Nana K. Ayisi‐Boateng Frailty syndrome and associated factors among patients with hypertension: A cross‐sectional study in Kumasi, Ghana Health Science Reports antihypertensives frailty syndrome high blood pressure hypertension medication adherence |
| title | Frailty syndrome and associated factors among patients with hypertension: A cross‐sectional study in Kumasi, Ghana |
| title_full | Frailty syndrome and associated factors among patients with hypertension: A cross‐sectional study in Kumasi, Ghana |
| title_fullStr | Frailty syndrome and associated factors among patients with hypertension: A cross‐sectional study in Kumasi, Ghana |
| title_full_unstemmed | Frailty syndrome and associated factors among patients with hypertension: A cross‐sectional study in Kumasi, Ghana |
| title_short | Frailty syndrome and associated factors among patients with hypertension: A cross‐sectional study in Kumasi, Ghana |
| title_sort | frailty syndrome and associated factors among patients with hypertension a cross sectional study in kumasi ghana |
| topic | antihypertensives frailty syndrome high blood pressure hypertension medication adherence |
| url | https://doi.org/10.1002/hsr2.1664 |
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