miR‐922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer
Abstract Gastric cancer (GC) is the second leading cause of cancer‐related death worldwide. Studies have shown that miR‐922 facilitates the development of various diseases and tumors. However, the role of miR‐922 in GC and related molecular mechanisms are still unrevealed. Current study indicated th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-03-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/kjm2.12155 |
| _version_ | 1818037236606697472 |
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| author | Paerhati Shayimu Jing‐Bin Wang Lin Liu Rousidan Tuerdi Cun‐Guo Yu Aikeremu Yusufu |
| author_facet | Paerhati Shayimu Jing‐Bin Wang Lin Liu Rousidan Tuerdi Cun‐Guo Yu Aikeremu Yusufu |
| author_sort | Paerhati Shayimu |
| collection | DOAJ |
| description | Abstract Gastric cancer (GC) is the second leading cause of cancer‐related death worldwide. Studies have shown that miR‐922 facilitates the development of various diseases and tumors. However, the role of miR‐922 in GC and related molecular mechanisms are still unrevealed. Current study indicated that miR‐922 was overexpressed in GC tissues and cells. The survival rate of patients in high miR‐922 expression group is significantly lower than that in low miR‐922 expression group. In addition, overexpression of miR‐922 observably restrained the apoptosis of SGC7901 cells and promoted SGC7901 cell proliferation, migration, and invasion. TargetScan predicted that suppressors of cytokine signaling 1 (SOCS1) was a potential target of miR‐922. miR‐922 upregulation profoundly inhibited the expression of SOCS1. Furthermore, the mRNA level of SOCS1 in GC tissues was significantly lower than that in adjacent tissues, indicating that miR‐922 promoted the proliferation, invasion, and migration, and inhibited apoptosis of SGC7901 cells by downregulating the level of SOCS1. In conclusion, miR‐922 may have potential for diagnosis of GC. |
| first_indexed | 2024-12-10T07:23:38Z |
| format | Article |
| id | doaj.art-4b36dbe3b8044dbcae19220378961108 |
| institution | Directory Open Access Journal |
| issn | 1607-551X 2410-8650 |
| language | English |
| last_indexed | 2024-12-10T07:23:38Z |
| publishDate | 2020-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-4b36dbe3b8044dbcae192203789611082022-12-22T01:57:44ZengWileyKaohsiung Journal of Medical Sciences1607-551X2410-86502020-03-0136317818510.1002/kjm2.12155miR‐922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancerPaerhati Shayimu0Jing‐Bin Wang1Lin Liu2Rousidan Tuerdi3Cun‐Guo Yu4Aikeremu Yusufu5Department of Gastrointestinal Surgery The 3rd Affiliated Teaching Hospital of Xin Jiang Medical University (Affiliated Cancer Hospital) Urumqi ChinaDepartment of Spleen and Stomach Disease Guangzhou University of Chinese Medicine‐Shenzhen Hospital Shenzhen Guangdong Province ChinaDepartment of Gastrointestinal Surgery The 3rd Affiliated Teaching Hospital of Xin Jiang Medical University (Affiliated Cancer Hospital) Urumqi ChinaGraduate School Xin Jiang Medical University Urumqi ChinaDepartment of Chinese Medicine Qinhuangdao Haigang Hospital Qinhuangdao Hebei Province ChinaDepartment of Gastrointestinal Surgery The 3rd Affiliated Teaching Hospital of Xin Jiang Medical University (Affiliated Cancer Hospital) Urumqi ChinaAbstract Gastric cancer (GC) is the second leading cause of cancer‐related death worldwide. Studies have shown that miR‐922 facilitates the development of various diseases and tumors. However, the role of miR‐922 in GC and related molecular mechanisms are still unrevealed. Current study indicated that miR‐922 was overexpressed in GC tissues and cells. The survival rate of patients in high miR‐922 expression group is significantly lower than that in low miR‐922 expression group. In addition, overexpression of miR‐922 observably restrained the apoptosis of SGC7901 cells and promoted SGC7901 cell proliferation, migration, and invasion. TargetScan predicted that suppressors of cytokine signaling 1 (SOCS1) was a potential target of miR‐922. miR‐922 upregulation profoundly inhibited the expression of SOCS1. Furthermore, the mRNA level of SOCS1 in GC tissues was significantly lower than that in adjacent tissues, indicating that miR‐922 promoted the proliferation, invasion, and migration, and inhibited apoptosis of SGC7901 cells by downregulating the level of SOCS1. In conclusion, miR‐922 may have potential for diagnosis of GC.https://doi.org/10.1002/kjm2.12155carcinogenesisgastric cancermiR‐922suppressors of cytokine signaling 1 |
| spellingShingle | Paerhati Shayimu Jing‐Bin Wang Lin Liu Rousidan Tuerdi Cun‐Guo Yu Aikeremu Yusufu miR‐922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer Kaohsiung Journal of Medical Sciences carcinogenesis gastric cancer miR‐922 suppressors of cytokine signaling 1 |
| title | miR‐922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer |
| title_full | miR‐922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer |
| title_fullStr | miR‐922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer |
| title_full_unstemmed | miR‐922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer |
| title_short | miR‐922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer |
| title_sort | mir 922 regulates apoptosis migration and invasion by targeting socs1 in gastric cancer |
| topic | carcinogenesis gastric cancer miR‐922 suppressors of cytokine signaling 1 |
| url | https://doi.org/10.1002/kjm2.12155 |
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